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5-alpha-reductase

5-alpha-reductase inhibitors block the enzymes that convert testosterone into dihydrotestosterone (DHT). Steroid 5α-reductases are membrane-bound enzymes that use NADPH (reduced nicotinamide adenine dinucleotide phosphate) to reduce a double bond in the steroid A ring. Human and rat forms of the enzyme were cloned and characterized in 1990. A second isozyme, steroid 5α-reductase 2 (SRD5A2), was reported in 1991, when deletions of its gene were found in male pseudohermaphroditism. Inhibitors are used to study androgen action in the prostate, skin and hair follicles. Finasteride and epristeride are steroidal inhibitors, and dutasteride blocks both isozymes. Plant-derived inhibitors in the category include β-sitosterol and the prenylated flavonoid Kushenol Q.

Items 26-30 of 30

  • MK-0963
    Cat. No.
    A69143
    CAS No.
    103497-68-3

    MK-0963

    Synonyms: L 654066

    MK-0963 is a steroidal inhibitor of 5α-reductase, effectively reducing serum dihydrotestosterone (DHT) levels in a dose-dependent manner. This compound is valuable for studying dihydrotestosterone-related conditions, including benign prostatic hyperplasia (BPH). Its ability to modulate DHT concentrations makes MK-0963 a significant tool in research aimed at understanding and treating disorders associated with androgen metabolism.

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  • FR-146687
    Cat. No.
    A69144
    CAS No.
    146939-64-2

    FR-146687

    Synonyms: FK 687; TF 505

    FR-146687 is a selective and orally bioavailable inhibitor of 5α-reductase, demonstrating IC50 values of 1.7 nM and 4.6 nM for rat and human enzymes, respectively. This compound exhibits specific inhibitory activity without affecting other steroid oxidoreductases. FR-146687 is utilized in research focused on disorders related to androgen metabolism and can aid in the development of therapeutic interventions targeting 5α-reductase-related pathways.

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    25 mg
    $1,905.00
    50 mg
    $2,445.00
    All 3 sizes
  • 5α-reductase-IN-1
    Cat. No.
    A69145
    CAS No.
    119348-12-8

    5α-reductase-IN-1

    5α-reductase-IN-1 is a potent inhibitor of 5α-reductase, an enzyme implicated in androgen metabolism. This compound is primarily utilized in research focused on androgenetic alopecia and may be investigated in conjunction with minoxidil to explore synergistic effects in hair regrowth studies. Its role in modulating testosterone derivatives offers valuable insights into potential therapeutic strategies for hair loss disorders.

    In stock View Details
    25 mg
    $1,530.00
    50 mg
    $1,950.00
    All 3 sizes
  • Dihydro Dutasteride
    Cat. No.
    A70343
    CAS No.
    164656-22-8

    Dihydro Dutasteride

    Dihydro Dutasteride is a metabolite of Dutasteride, functioning as a potent inhibitor of both isoforms of the 5α-reductase enzyme. This compound exhibits significant biological activity in the modulation of androgen levels, making it valuable for research applications related to prostate health and hair loss disorders. Its inhibitory effects on 5α-reductase facilitate investigations into androgen metabolism and related pathologies.

    In stock View Details
    5 mg
    $135.00
    10 mg
    $220.00
    All 5 sizes
  • 5β-Dutasteride
    Cat. No.
    A70503
    CAS No.
    957229-52-6

    5β-Dutasteride

    5β-Dutasteride is a selective inhibitor of both isoforms of 5α-reductase. By inhibiting this enzyme, it effectively reduces the conversion of testosterone to dihydrotestosterone (DHT), making it valuable in studying androgen-related disorders. Its potent biological activity supports research applications in androgen-related conditions, including benign prostatic hyperplasia and androgenetic alopecia.

    In stock View Details
    5 mg
    $495.00
    25 mg
    $1,275.00
    All 4 sizes

Items 26-30 of 30

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