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Progesterone receptor agonists and antagonists act on a nuclear receptor for progesterone. The progesterone receptor (PR) occurs as two isoforms, PR-A and PR-B, which are transcribed from two estrogen-regulated promoters of one gene. Work in mice assigned a defined subset of reproductive responses to progesterone to the PR-B isoform alone. Medroxyprogesterone acetate and drospirenone are synthetic progestins that activate the receptor in cell and tissue models. Lonaprisan blocks receptor activation, while ulipristal acetate behaves as a selective receptor modulator with mixed agonist and antagonist behavior. Tamoxifen citrate is listed here as well, since steroid receptor crosstalk is often studied together with the related Estrogen Receptors category.
Synonyms: Primolut Depot; Proge; Delalutin
Hydroxyprogesterone caproate is a synthetic, steroidal progestin; an ester derivative of 17?α-hydroxyprogesterone formed from caproic acid.
