We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

ROR

ROR modulators target retinoic acid receptor-related orphan receptors (RORs), a family of nuclear receptors. The family has three members, RORĪ±, RORĪ² and RORĪ³, which bind ROR response elements in target genes and are active without an added ligand. RORĪ± contributes to circadian clock regulation, and the immune isoform RORĪ³t directs the differentiation of interleukin-17 (IL-17)-producing T helper (Th17) cells. In 2011 the synthetic RORĪ±/Ī³ ligand SR1001 was shown to suppress Th17 differentiation and autoimmunity in mice. SR-2211 and XY101 act on RORĪ³, whereas SR3335 is selective for RORĪ±. SR1078 is used as an agonist of RORĪ± and RORĪ³ in studies of target gene expression. Related receptors without well-defined ligands are listed under Orphan Nuclear Receptor.

1 Item

  • Antitumor agent-127
    Cat. No.
    A77575
    CAS No.
    3034861-58-7

    Antitumor agent-127

    Antitumor agent-127 is a macrocyclic peptide that targets the ROR1 receptor. It exhibits nanomolar affinity for ROR1, demonstrating effective binding and substantial internalization in 786-O and MDA-MB-231 tumor cell lines. This compound is valuable for research in cancer biology, particularly in studies focused on ROR1-mediated signaling pathways and potential therapeutic applications in tumors expressing ROR1.

    In stock View Details
    5 mg
    $135.00
    10 mg
    $205.00
    All 5 sizes

1 Item

Added to your cart

View Cart Checkout

    Loading...