We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Retinoid Receptor

Retinoid receptor ligands act on retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Both are nuclear receptors with α, β and γ subtypes that bind DNA as RAR-RXR heterodimers and regulate gene transcription. A receptor for the morphogen retinoic acid was identified in 1987 as a member of the nuclear receptor family. In 1990 a second receptor responding to retinoic acid, later named RXRα, revealed a distinct retinoid pathway. Tretinoin, the all-trans form of retinoic acid, activates RARs, while tamibarotene and AM 580 favor RARα and CD 437 favors RARγ. Adapalene, tazarotene, acitretin and fenretinide are synthetic retinoids, whereas bexarotene is a ligand selective for RXRs.

1 Item

  • Ch55-O-C3-NH2
    Cat. No.
    A39674
    CAS No.
    144298-98-6

    Ch55-O-C3-NH2

    Synonyms: RAR ligand 1

    Ch55-O-C3-NH2 is a selective ligand for retinoic acid receptors (RAR) and retinoid X receptors (RXR). This compound demonstrates the ability to effectively modulate RAR signaling pathways, facilitating research into their role in gene expression and developmental processes. Ch55-O-C3-NH2 can also be utilized in the synthesis of SNIPERs by binding to cIAP1 ligand Bestatin through a linker, supporting studies in targeted protein degradation and therapeutic applications.

    View Details

    Out of stock

    All 3 sizes

1 Item

Added to your cart

View Cart Checkout

    Loading...