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Pregnane X Receptors

Pregnane X receptor (PXR) agonists activate a nuclear receptor that senses foreign compounds. PXR was reported in 1998 as an orphan nuclear receptor activated by pregnane steroids. In the same year, human PXR was shown to respond to compounds that induce cytochrome P450 3A4 (CYP3A4) and cause drug interactions. Ligand-bound PXR pairs with retinoid X receptor (RXR) and raises the expression of drug-metabolizing enzymes and transporters in liver and intestine. Rifampin and SR-12813 activate human PXR, while pregnenolone 16α-carbonitrile is the classic rodent agonist. Other listed activators include (3S,5S)-Atorvastatin, SJPYT-328, isobutylparaben and the bile acid precursor 7α-Hydroxy-4-cholesten-3-one.

2 Items

  • PXR Ligand 2
    Cat. No.
    A81300
    CAS No.
    3059971-00-2

    PXR Ligand 2

    PXR Ligand 2 (Compound 55) is a potent ligand for the pregnane X receptor (PXR), a nuclear receptor involved in the regulation of drug metabolism and detoxification pathways. This compound facilitates the targeted degradation of SMARCA2 and SMARCA4 through PROTAC technology, making it a valuable tool for investigating chromatin remodeling and cancer biology. Its application in targeted protein degradation studies positions PXR Ligand 2 as a crucial reagent for research in molecular biology and pharmacology.

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    Out of stock

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  • 4-Chloro-2-(trifluoroacetyl)aniline
    Cat. No.
    A85381
    CAS No.
    154598-53-5

    4-Chloro-2-(trifluoroacetyl)aniline

    4-Chloro-2-(trifluoroacetyl)aniline is a potent ligand for the Pregnane X receptor (PXR). This compound is notable for its ability to induce Cyp3a11 mRNA expression, making it a valuable tool in studies of PXR-mediated drug metabolism and detoxification pathways. Its research applications are particularly relevant in pharmacology and toxicology, where understanding PXR activation can inform drug interactions and therapeutic efficacy.

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    100 mg
    $30.00
    250 mg
    $60.00
    All 4 sizes

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