Glucocorticoid Receptors

Cat. No.

A36026

CAS No.

1206876-95-0

PF-04308515

Synonyms: PF 4308515

PF-04308515 is a selective glucocorticoid receptor ligand that exhibits significant anti-inflammatory properties. It effectively inhibits the production of interleukin-6 (IL-6) and interferon gamma (IFNγ), making it a valuable tool for studying inflammation and immune responses. Additionally, PF-04308515 induces a weak interaction with PGC1α, providing insights into its potential metabolic effects. This compound is useful for research applications focused on inflammation, autoimmune diseases, and glucocorticoid signaling pathways.

Cat. No.

A41373

CAS No.

2166376-64-1

Glucocorticoid receptor agonist-2 Ala-Ala-Mal

Glucocorticoid receptor agonist-2 Ala-Ala-Mal acts as an active reference for ABBV-3373 and serves as a ligand for the glucocorticoid receptor. This compound is instrumental in the synthesis of antibody-drug conjugates (ADCs) with anti-inflammatory properties. Its ability to modulate glucocorticoid receptor activity makes it a valuable reagent in the development of therapeutics targeting inflammatory diseases.

Cat. No.

A64706

CAS No.

86401-95-8

Methylprednisolone aceponate

Synonyms: ZK 91588; MPA

Methylprednisolone aceponate is a glucocorticoid with a specific mechanism of action as a selective glucocorticoid receptor ligand, primarily functioning as an anti-inflammatory agent. It exhibits weak systemic effects, making it particularly useful in the treatment of localized inflammatory conditions. This compound is valuable for research applications targeting eczema and other inflammatory skin disorders, aiding in the understanding of their pathophysiology and potential treatments.

Cat. No.

A64812

CAS No.

960248-81-1

(Rac)-GSK866

Synonyms: GSK47866A

(Rac)-GSK866 is a non-steroidal ligand that targets the glucocorticoid receptor (GR). This compound serves as an important tool for investigating GR functionality by providing insights into ligand binding mechanisms. The crystal structure of (Rac)-GSK866 in complex with the GR ligand-binding domain (PDB: 3E7C) can facilitate the exploration of GR-targeted therapeutic strategies and the development of novel GR modulators.

Cat. No.

A64822

CAS No.

83880-39-1

Win 45164

Win 45164 is an orally active ligand of the glucocorticoid receptor, primarily known for its inhibitory effects on the pituitary-adrenal axis. It promotes liver glycogen deposition and thymus involution in adrenalectomized male rats, highlighting its physiological relevance. Additionally, Win 45164 exhibits significant anti-inflammatory properties, making it a valuable tool for research in inflammatory and neurological diseases.