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Nur77

Nur77 agonists, antagonists and modulators act on Nur77, an orphan receptor of the nuclear receptor family. Its gene is named nuclear receptor subfamily 4 group A member 1 (NR4A1). Nur77 is an immediate early gene product induced by growth factors, stress and T-cell receptor signaling. Besides acting as a transcription factor, Nur77 can move to mitochondria, where it triggers cytochrome c release and apoptosis. A 2008 study identified the fungal metabolite cytosporone B as a Nur77 agonist that binds the ligand-binding domain. The listed compounds include the diindolylmethane analogs DIM-C-pPhOH and DIM-C-pPhCO2Me, which act as NR4A1 antagonists, and the ligand-binding domain antagonist TMPA.

1 Item

  • 4-PQBH
    Cat. No.
    A53932
    CAS No.
    2243355-51-1

    4-PQBH

    4-PQBH is a potent binder of Nur77, exhibiting a dissociation constant (KD) of 1.17 μM. This compound significantly induces caspase-independent cytoplasmic vacuolization and paraptosis through the mediation of endoplasmic reticulum (ER) stress and autophagy pathways. 4-PQBH serves as a valuable tool for cancer research, particularly in the study of cell death mechanisms and neurodegenerative disorders.

    In stock View Details
    1 mg
    $55.00
    5 mg
    $125.00
    All 6 sizes

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