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Vitamin D receptor ligands include calcitriol analogs and labeled vitamin D reference compounds. The vitamin D receptor (VDR) was cloned in 1988 and belongs to the nuclear receptor superfamily, binding DNA as a heterodimer with the retinoid X receptor. Its natural ligand, 1,25-dihydroxyvitamin D3, is formed from vitamin D by sequential hydroxylation in liver and kidney. Eldecalcitol, falecalcitriol and seocalcitol are synthetic analogs of that hormone and are used to compare receptor activation and gene induction. Vitamin D2 serves as a precursor form in such comparisons, and deuterated material such as Calcitriol D6 supports mass spectrometric measurement of vitamin D metabolites.
Synonyms: PRI 2202; Impurity D of Calcipotriol
24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.
Synonyms: Impurity A of Calcipotriol; MC1046. MC-1046
MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.
LG190178 is a non-steroidal ligand for the vitamin D receptor (VDR), acting to induce heterodimer formation between VDR and retinoid X receptor (RXR). This stabilizes the agonistic conformation of the VDR ligand-binding domain, enhancing interactions with co-activators. Its biological activity impacts calcium homeostasis, bone mineralization, and cellular processes such as proliferation, differentiation, and apoptosis, making LG190178 a valuable tool for research into conditions like psoriasis, osteoporosis, and cancer.
