p38-MAPK

Cat. No.

A36866

CAS No.

2518299-32-4

AMG-548 dihydrochloride

AMG-548 dihydrochloride is a selective p38α inhibitor with a Ki of 0.5 nM, exhibiting moderate selectivity towards p38β (Ki = 36 nM) and over 1000-fold selectivity against p38γ and p38δ isoforms. This compound demonstrates potent inhibition of TNFα production in whole blood stimulated by LPS, with an IC50 of 3 nM. Additionally, AMG-548 dihydrochloride inhibits Wnt signaling by directly targeting Casein kinase 1 isoforms δ and ε, making it valuable for research in inflammation and signaling pathways.

Cat. No.

A36943

CAS No.

2437438-16-7

AMG-548 hydrochloride

AMG-548 hydrochloride is a selective inhibitor targeting p38α with a Ki of 0.5 nM and shows moderate selectivity for p38β (Ki=36 nM), while exhibiting over 1000-fold selectivity against p38γ and p38δ. This compound effectively inhibits TNFα production in whole blood stimulated by LPS, with an IC50 of 3 nM. Additionally, AMG-548 hydrochloride disrupts Wnt signaling through the direct inhibition of Casein kinase 1 isoforms δ and ε, making it a valuable reagent for studies in inflammation and cancer research.

Cat. No.

A36968

CAS No.

1572047-63-2

p38α inhibitor 8

p38α inhibitor 8 selectively inhibits p38α MAPK and CK1δ, with IC50 values of 0.21 µM and 0.202 µM, respectively. This compound is valuable for studies exploring cellular stress responses and inflammatory pathways, making it a potent tool in cancer research and immunology. Its ability to modulate these kinases presents opportunities for investigating therapeutic strategies in various diseases.

Cat. No.

A36970

CAS No.

1572047-84-7

p38α MAPK/CK1δ inhibitor-1

p38α MAPK/CK1δ inhibitor-1 is a selective inhibitor targeting p38α MAPK and CK1δ, exhibiting IC50 values of 0.185 µM and 0.089 µM, respectively. This compound plays a crucial role in modulating cellular responses associated with stress and inflammatory pathways. Its inhibition of both kinases makes it a valuable tool for investigating signaling pathways and therapeutic strategies in various disease models.

Cat. No.

A37534

CAS No.

276690-61-0

Iroxanadine sulfate

Synonyms: (-)-BRX 005 sulfate; (-)-BRX 235 sulfate

Iroxanadine sulfate is a dual activator of p38 kinase and heat shock protein (HSP), functioning as a vasculoprotector. This compound exhibits significant biological activity relevant to vascular health and has potential applications in the study of atherosclerosis and other vascular diseases. Researchers may utilize Iroxanadine sulfate to explore therapeutic strategies aimed at modulating p38 and HSP signaling pathways in various models of vascular pathology.

Cat. No.

A37628

CAS No.

203805-20-3

(±)-Iroxanadine (BRX 005, BRX 235)

Synonyms: BRX 005; BRX 235

(±)-Iroxanadine serves as a p38 kinase and heat shock protein (HSP) activator, demonstrating vasculoprotective properties. This compound is pertinent for research into atherosclerosis and various vascular diseases, facilitating studies aimed at understanding the molecular mechanisms underlying these conditions. Its activation of key signaling pathways makes it a valuable tool for exploring therapeutic targets in cardiovascular research.

Cat. No.

A37632

CAS No.

276690-59-6

Iroxanadine hydrochloride

Synonyms: (-)-BRX 005 hydrochloride; (-)-BRX 235 hydrochloride

Iroxanadine hydrochloride is a dual activator of p38 mitogen-activated protein kinase (MAPK) and heat shock proteins (HSPs). It exhibits vasculoprotective properties, making it a valuable tool for investigating mechanisms underlying atherosclerosis and various vascular diseases. This reagent is suitable for research applications focused on the modulation of inflammatory responses and cellular stress pathways.

Cat. No.

A37639

CAS No.

276690-62-1

Iroxanadine hydrobromide

Synonyms: (-)-BRX 005 hydrobromide; (-)-BRX 235 hydrobromide

Iroxanadine hydrobromide is a potent activator of p38 MAPK and HSP proteins. This compounds biological activity focuses on vasculoprotection, making it a valuable tool for investigating atherosclerosis and other vascular diseases. Its dual activation mechanisms provide insights into cellular stress responses and inflammation, making it relevant for research applications in cardiovascular health.

Cat. No.

A37640

CAS No.

276690-58-5

Iroxanadine

Synonyms: (-)-BRX 005; (-)-BRX 235

Iroxanadine is a dual activator of p38 MAPK and heat shock proteins (HSPs). It exhibits vasculoprotective properties, making it a valuable reagent for studying atherosclerosis and other vascular diseases. This compound can be utilized in research focusing on inflammatory responses and cardiovascular health, providing insights into the mechanisms underlying these conditions.

Cat. No.

A38820

CAS No.

103-81-1

2-Phenylacetamide

2-Phenylacetamide is a potent inhibitor of the p38 MAPK signaling pathway. This compound demonstrates significant anti-inflammatory, antioxidant, anti-hypertensive, and anti-fibrotic properties, making it a valuable tool for investigating various biological processes. Additionally, 2-Phenylacetamide is orally active, facilitating its use in in vivo research applications.

Cat. No.

A39351

CAS No.

1006378-90-0

p38 MAPK-IN-1

p38 MAPK-IN-1 is a selective inhibitor of p38 MAPK, exhibiting an IC50 of 68 nM. This compound demonstrates sustained plasma levels, low clearance, and favorable bioavailability, making it an effective tool for biological research. p38 MAPK-IN-1 is primarily utilized in studies investigating inflammatory responses, apoptosis, and various disease states involving p38 MAPK signaling pathways.

Cat. No.

A39425

CAS No.

1283526-53-3

Doramapimod hydrochloride

Synonyms: BIRB 796 hydrochloride

Doramapimod hydrochloride is a selective inhibitor of p38 MAPK, a key regulator in inflammatory responses. This compound effectively attenuates the production of pro-inflammatory cytokines, including TNF-α and IL-1β, in response to LPS, LTA, and PGN stimulation. Its potent anti-inflammatory properties make Doramapimod hydrochloride valuable for researching various autoimmune diseases and inflammatory pathways.

Cat. No.

A39541

CAS No.

158876-66-5

FR 167653

Synonyms: FR 167653 sulfate

FR 167653 is a selective inhibitor of p38 mitogen-activated protein kinase (MAPK), demonstrating significant suppression of pro-inflammatory cytokines such as TNF-α and IL-1β through targeted inhibition of p38 MAPK activity. This compound is effective in preclinical models for managing inflammation and provides therapeutic benefits in conditions related to trauma and ischemia-reperfusion injury. Its ability to modulate inflammatory responses makes it a valuable tool for research in inflammation and related disorders.

Cat. No.

A39726

CAS No.

937169-00-1

Dilmapimod tosylate

Synonyms: SB-681323 tosylate; GW 681323 tosylate

Dilmapimod tosylate is a potent inhibitor of p38 mitogen-activated protein kinase (MAPK), a key regulator of inflammatory responses. This compound exhibits significant biological activity by reducing pro-inflammatory cytokine production, making it a valuable tool in studying inflammatory processes. It has potential applications in researching chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD).

Cat. No.

A39773

CAS No.

635725-16-5

p38 MAPK-IN-2

p38 MAPK-IN-2 is a selective inhibitor of p38 mitogen-activated protein kinase (MAPK). This compound effectively attenuates p38 MAPK signaling, leading to decreased phosphorylation of downstream targets involved in inflammatory responses. It is valuable for researchers studying cellular stress responses, cytokine signaling, and potential therapeutic effects in various inflammatory diseases and cancer.

Cat. No.

A40468

CAS No.

219769-23-0

SB-284851-BT

SB-284851-BT is a selective inhibitor of BRD4, p38α, and BRDT. It effectively inhibits BRD4-BD1 with an IC50 of 1.7 µM, p38α with a Kd of 0.47 nM, and exhibits additional inhibitory activity against BRDT and BRD4 with IC50 values of 18 µM and 3.7 µM, respectively. SB-284851-BT significantly reduces IL-8 production through p38α inhibition and downregulates crucial oncogenic pathways such as c-Myc and NF-κB via BRD4 inhibition. This compound has potential applications in cancer research and therapeutic development targeting cellular signaling pathways.

Cat. No.

A40663

CAS No.

153316-01-9

OVA-E1 peptide

OVA-E1 peptide is an activator of p38 MAPK, derived from the original SIINFEKL sequence (OVA 257-264). This peptide effectively stimulates both p38 and JNK signaling pathways in both mutant and wild-type thymocytes. It serves as a valuable tool for studying MAPK pathways and their roles in cellular responses such as inflammation and stress signaling in various research applications.

Cat. No.

A40668

CAS No.

2531396-44-6

HE4-1 leech peptide

HE4-1 leech peptide is a selective inhibitor of p38 MAPK and c-Jun N-terminal kinase (JNK). It effectively suppresses macrophage migration while maintaining normal macrophage immunological functions, such as phagocytosis, lysozyme activity, and the expression of various inflammatory factors. This peptide is primarily utilized in research focused on atherosclerosis and inflammation-related studies.

Cat. No.

A40673

CAS No.

2745108-35-2

TOPK-p38/JNK-IN-1

TOPK-p38/JNK-IN-1 is an orally active inhibitor targeting the TOPK-p38/JNK signaling pathway, exhibiting an IC50 value of 2.14 µM for nitric oxide production. This compound demonstrates significant anti-inflammatory activity by inhibiting the phosphorylation of downstream proteins while preventing degradation of TOPK. Research applications include studies on inflammatory processes and cellular signaling mechanisms in various disease models.

Cat. No.

A40675

CAS No.

1164153-37-0

SR-3737

SR-3737 is a potent inhibitor of JNK3 and p38 mitogen-activated protein kinases, with IC50 values of 12 nM and 3 nM, respectively. This compound exhibits significant biological activity by modulating pathways involved in stress responses and inflammation. SR-3737 is useful in research applications focusing on neuronal signaling, cytokine production, and the molecular mechanisms underlying various neurodegenerative diseases.

Cat. No.

A40681

CAS No.

815595-25-6

p38 Kinase inhibitor 8

p38 Kinase Inhibitor 8 is a selective inhibitor of p38β and JNK2α2, demonstrating IC50 values of 6.3 nM and 53.6 nM, respectively. This compound has shown significant anti-inflammatory properties in models of collagen-induced arthritis in rats, making it a valuable tool for research into inflammatory diseases and related signaling pathways. Its orally active nature enhances its practicality for in vivo studies.

Cat. No.

A40744

CAS No.

489-35-0

Gossypetin

Gossypetin is a hexahydroxylated flavonoid that primarily targets the p38 MAPK signaling pathway by inhibiting mitogen-activated protein kinase kinases MKK3 and MKK6. This inhibition effectively attenuates the MKK3/6-p38 signaling pathway, leading to multiple pharmacological effects, including antioxidant, antibacterial, and anticancer activities. Gossypetin is of interest in research exploring therapeutic applications against various diseases mediated by p38 MAPK signaling dysregulation.

Cat. No.

A40747

CAS No.

10597-89-4

N-Acetylmuramic acid

Synonyms: MurNAc; NAMA

N-Acetylmuramic acid is a key component of the bacterial cell wall peptidoglycan, targeting the p38 MAPK signaling pathway. It plays a critical role in maintaining cell shape and integrity in bacterial species, particularly Bacteroides forsythus, while also inhibiting spore germination through the inhibition of hexosaminidase and core enzymes. Additionally, N-acetylmuramic acid exhibits significant anti-inflammatory activity, making it a valuable reagent in studies of cellular proliferation and inflammatory responses. This compound is noted for its oral bioactivity.

Cat. No.

A40748

CAS No.

1001405-52-2

PSMα3

PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK, playing a significant role in modulating inflammatory pathways. This compound forms membrane pores and interacts with the human insulin B chain, inhibiting insulin aggregation and contributing to cytotoxic effects through α-type amyloid-like fibril formation. PSMα3 is valuable for research on spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and infections caused by Staphylococcus aureus.

Cat. No.

A40760

CAS No.

30557-81-4

Bisabolangelone

Bisabolangelone is a potent inhibitor of the p38 MAPK pathway. Isolated from the roots of Osterici Radix, this sesquiterpene derivative demonstrates significant anti-inflammatory activity by inhibiting LPS-stimulated inflammation through the blockade of the NF-kappaB and MAPK signaling pathways in macrophages. Additionally, Bisabolangelone exhibits anti-ulcer activities, making it a valuable tool in studies related to inflammation and gastrointestinal disorders.