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p38-MAPK

p38 mitogen-activated protein kinase (MAPK) inhibitors act on stress-activated kinases of the MAPK family. In 1994 p38 was described as a kinase phosphorylated on tyrosine after exposure of cells to bacterial endotoxin or hyperosmolarity. In the same year, a kinase targeted by pyridinyl imidazole compounds was shown to regulate the biosynthesis of inflammatory cytokines. Adezmapimod, also known as SB 203580, and SB 202190 belong to this pyridinyl imidazole class and inhibit p38α and p38β. Doramapimod binds an allosteric pocket that becomes accessible in an inactive conformation of the kinase, a binding mode reported in 2002. PH-797804 and ralimetinib dimesylate are further p38α inhibitors for studies of inflammatory and stress signaling.

Items 176-193 of 193

  • R 1487
    Cat. No.
    A40853
    CAS No.
    449811-92-1

    R 1487

    R 1487 is a highly selective inhibitor of the p38α mitogen-activated protein kinase. It demonstrates promising biological activity by effectively modulating inflammatory signaling pathways, making it a valuable tool in the study of rheumatoid arthritis and other inflammatory conditions. This compound enables researchers to delve into the mechanisms of p38α inhibition and its potential therapeutic applications in chronic inflammatory diseases.

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    1 mg
    $20.00
    5 mg
    $105.00
    All 6 sizes
  • PS-166276
    Cat. No.
    A40857
    CAS No.
    348089-57-6

    PS-166276

    PS-166276 is a potent inhibitor of p38 mitogen-activated protein kinase (MAPK). With an IC50 of 28 nM against p38 kinase, it demonstrates significant inhibitory effects while maintaining lower cytotoxicity. This reagent is valuable for research applications focusing on inflammation, cell signaling, and related therapeutic pathways involving p38 MAPK modulation.

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    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • p38α inhibitor 4
    Cat. No.
    A40859
    CAS No.
    1262406-08-5

    p38α inhibitor 4

    p38α Inhibitor 4 is a selective allosteric inhibitor targeting the p38α MAPK pathway, demonstrated by an IC50 value of 1.2 μM. This compound exhibits specificity for p38α, showing no activity against p38β, p38γ, and p38δ. p38α Inhibitor 4 is valuable for research exploring inflammatory responses, cell signaling pathways, and related disorders where p38α activity plays a critical role.

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    1 mg
    $235.00
    5 mg
    $310.00
    All 6 sizes
  • Anti-inflammatory agent 7
    Cat. No.
    A40860
    CAS No.
    2759194-24-4

    Anti-inflammatory agent 7

    Anti-inflammatory agent 7 is a selective p38 MAPK inhibitor that modulates the NF-κB/MAPK signaling pathway to inhibit proinflammatory cytokine production. This reagent demonstrates significant anti-inflammatory activity in LPS-treated RAW 264.7 cells and in in vivo models, making it a valuable tool for studying inflammatory responses and developing therapeutic strategies for related diseases.

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  • CP-944629
    Cat. No.
    A40862
    CAS No.
    668990-94-1

    CP-944629

    CP-944629 is a potent inhibitor of p38 alpha kinase with an IC50 value of 3.2 μM. This compound effectively modulates the p38 MAPK signaling pathway, making it valuable in the study of chronic inflammatory diseases. Its ability to inhibit p38 alpha kinase may provide insights into therapeutic strategies for conditions driven by excessive inflammation.

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    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • NJK14047
    Cat. No.
    A40863
    CAS No.
    1800576-41-3

    NJK14047

    NJK14047 is a selective inhibitor of p38 MAPK, a key signaling pathway involved in inflammatory responses. This compound effectively inhibits the differentiation of naive T-cells into Th1 and Th17 cells, thus modulating immune responses. NJK14047 has demonstrated therapeutic potential in preclinical models, ameliorating collagen-induced rheumatoid arthritis and imiquimod-induced psoriasis in mice, making it a valuable tool for research into inflammatory diseases and immune regulation.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • p38-α MAPK-IN-10
    Cat. No.
    A40864
    CAS No.
    200801-77-0

    p38-α MAPK-IN-10

    p38-α MAPK-IN-10 is a potent inhibitor of p38α MAPK, exhibiting an IC50 value of 4 nM. This compound is utilized in research to investigate the role of p38α in inflammatory processes, cellular stress responses, and various pathological conditions. Its selective inhibition makes it an essential tool for studying signal transduction pathways and developing potential therapeutic strategies.

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  • SB 202474
    Cat. No.
    A40866
    CAS No.
    172747-50-1

    SB 202474

    SB 202474 is a negative control compound designed for p38 MAPK inhibition studies. Unlike its active analog SB203580, SB 202474 does not inhibit p38 MAPK activity, making it an essential tool for validating experimental results in MAPK pathways. Additionally, it has been shown to suppress melanin synthesis induction, providing further applications in biochemical research related to pigment production.

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    1 mg
    $265.00
    All 1 sizes
  • p38 Kinase inhibitor 7
    Cat. No.
    A40867
    CAS No.
    815595-14-3

    p38 Kinase inhibitor 7

    p38 Kinase Inhibitor 7 is a potent inhibitor of p38α with an IC50 value of 5.25 nM. This compound effectively reduces TNFα production in THP-1 cells, demonstrating an IC50 of 5.88 nM. p38 Kinase Inhibitor 7 is valuable for research focused on inflammation and related signaling pathways, making it a useful tool in cytokine modulation studies.

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  • SB-204900
    Cat. No.
    A40868
    CAS No.
    173220-67-2

    SB-204900

    SB-204900 is a selective inhibitor of p38 mitogen-activated protein kinase (MAPK). This compound exhibits significant inhibition of p38 MAPK phosphorylation, making it a valuable tool in the study of inflammatory signaling pathways. SB-204900 is primarily utilized in research focused on understanding the molecular mechanisms underlying inflammatory responses and developing potential therapeutic strategies for related conditions.

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    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • FS-694
    Cat. No.
    A40869
    CAS No.
    1417404-27-3

    FS-694

    FS-694 is a potent inhibitor of p38α, exhibiting an IC50 of 0.2 nM. This compound effectively suppresses TNFα release in human whole blood, with an IC50 value of 35.0 nM. FS-694 can be utilized in research aimed at understanding p38α signaling pathways and investigating inflammatory responses.

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    Out of stock

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  • SC-68376
    Cat. No.
    A40870
    CAS No.
    318480-82-9

    SC-68376

    SC-68376 is a selective, reversible inhibitor of p38 MAP kinase, functioning through competitive inhibition of ATP binding. This compound exhibits significant biological activity in modulating inflammatory responses and cellular stress signaling pathways. SC-68376 is valuable for research applications related to inflammation, neurodegenerative diseases, and cancer, enabling the exploration of p38 MAP kinase's role in various pathological conditions.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • p38-α MAPK-IN-9
    Cat. No.
    A40871
    CAS No.
    868272-50-8

    p38-α MAPK-IN-9

    p38-α MAPK-IN-9 is a highly potent inhibitor of the p38-α mitogen-activated protein kinase (MAPK), exhibiting a Ki value of 0.057 nM. This compound effectively inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNFα) production in human peripheral blood mononuclear cells (hPBMCs), with an IC50 of 18 nM. p38-α MAPK-IN-9 is valuable for research applications focused on inflammatory signaling pathways and the study of cytokine modulation.

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  • p38 MAP Kinase Inhibitor Ⅵ
    Cat. No.
    A40872
    CAS No.
    421578-46-3

    p38 MAP Kinase Inhibitor Ⅵ

    p38 MAP Kinase Inhibitor VI is a selective inhibitor of p38 MAPK, exhibiting a moderate inhibition rate of 24%. This compound is instrumental in research focused on inflammation, apoptosis, and cellular stress responses. It can be utilized to explore the role of p38 MAPK in various pathological conditions and to develop therapeutic strategies targeting this signaling pathway.

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    1 mg
    $60.00
    5 mg
    $155.00
    All 7 sizes
  • p38 MAP Kinase-IN-1
    Cat. No.
    A40873
    CAS No.
    815595-27-8

    p38 MAP Kinase-IN-1

    p38 MAP Kinase-IN-1 is a selective inhibitor of the p38 MAP kinase pathway, which plays a crucial role in mediating inflammation and immune responses. This compound is valuable for researchers investigating the mechanisms behind inflammatory diseases and autoimmune disorders. It can facilitate studies aimed at understanding p38's role in cellular signaling and its potential as a therapeutic target in inflammatory-related conditions.

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  • p38 MAPK-IN-6
    Cat. No.
    A40874
    CAS No.
    421578-44-1

    p38 MAPK-IN-6

    p38 MAPK-IN-6 is a selective p38 MAPK inhibitor that exhibits potential in modulating inflammatory pathways and stress responses. With a demonstrated inhibitory effect of 14% at a concentration of 10 μM, this compound serves as a valuable tool for studying p38 MAPK signaling in various cellular models. Its application extends to research in conditions associated with chronic inflammation and related diseases.

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    Out of stock

    All 3 sizes
  • AKP-001
    Cat. No.
    A40875
    CAS No.
    897644-83-6

    AKP-001

    AKP-001 is a selective inhibitor of p38 mitogen-activated protein kinase (p38 MAPK). This compound effectively reduces the production of pro-inflammatory cytokines, making it valuable for studying inflammatory processes. AKP-001 is particularly relevant for research focused on rheumatoid arthritis and inflammatory bowel disease, providing insights into potential therapeutic interventions for these conditions.

    In stock View Details
    1 mg
    $235.00
    5 mg
    $590.00
    All 4 sizes
  • 2-Hydroxyisobutyric acid
    Cat. No.
    A71190
    CAS No.
    594-61-6

    2-Hydroxyisobutyric acid

    2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 signaling pathway and p38 MAPK pathway, known for its ability to decrease reactive oxygen species and fat accumulation in Caenorhabditis elegans. This compound enhances β-oxidation while suppressing fatty acid synthesis via upregulation of SKN-1/NRF2 and downregulation of SREBP-1c transcription factors. 2-HIBA exhibits notable anti-aging and lipid-lowering properties, making it valuable for investigating metabolic diseases, including obesity and diabetes. Additionally, it serves as a renewable precursor for methacrylate production through 2-HIB-CoA mutase-mediated biosynthesis.

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    100 mg
    $25.00
    200 mg
    $30.00
    All 5 sizes

Items 176-193 of 193

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