Mycobacterium tuberculosis | Adooq Bioscience

Cat. No.: A49715

CAS No.: 2861190-30-7

Mtb-IN-2

Mtb-IN-2 is an antimicrobial agent specifically targeting Mycobacterium tuberculosis (Mtb). Demonstrating significant efficacy, Mtb-IN-2 effectively reduces colony-forming units (CFU) in murine tuberculosis models, providing utility against both drug-sensitive and drug-resistant Mtb H37Rv strains. The compound influences methionine metabolism, while not directly impacting the folate pathway, making it a valuable tool for research into Mtb infection and drug resistance mechanisms.

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$55.00

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$130.00

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Cat. No.: A49760

CAS No.: 2225885-99-2

MtTMPK-IN-6

MtTMPK-IN-6 is a selective inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtbTMPK), exhibiting an IC50 value of 29 μM. This compound serves as a valuable tool for investigating the biochemical pathways involved in tuberculosis and may aid in the development of novel therapeutic strategies against M. tuberculosis. Its potency and specificity make it a relevant candidate for further research in the field of infectious diseases.

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Cat. No.: A49822

CAS No.: 2919699-59-3

MSU-43557

MSU-43557 is a selective inhibitor of the mycobacterial transporter MmpL3 (MAB_4508), demonstrating potent bactericidal activity against Mycobacterium abscessus. By inhibiting MmpL3, MSU-43557 disrupts the synthesis of trehalose monomycolate, leading to a significant reduction in the viability of biofilm-associated M. abscessus and intracellular forms. This compound exhibits low cytotoxicity in eukaryotic cells and a minimal resistance frequency in M. abscessus strains, making it a valuable tool for research into mycobacterial infections.

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Cat. No.: A49837

CAS No.: 2345638-96-0

Polyketide synthase 13-IN-1

Polyketide Synthase 13-IN-1 is an inhibitor of polyketide synthase 13, targeting the biosynthetic pathway of polyketides. This compound is significant in research focused on antibiotic development and the synthesis of complex natural products. Its activity provides valuable insights into polyketide metabolism and the potential therapeutic applications of polyketide derivatives.

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Cat. No.: A49844

CAS No.: 1364683-67-9

LeuRS-IN-1 hydrochloride

LeuRS-IN-1 hydrochloride is an effective inhibitor of M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS), showcasing sub-micromolar potency with IC50 and Kd values of 0.06 μM and 0.075 μM, respectively. This compound also inhibits human cytoplasmic leucyl-tRNA synthetase with an IC50 of 38.8 μM and affects protein synthesis in HepG2 cells, demonstrating an EC50 of 19.6 μM. LeuRS-IN-1 hydrochloride is valuable for investigating the mechanisms of antibiotic resistance and for exploring new therapeutic strategies against tuberculosis.

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Cat. No.: A49848

CAS No.: 1254782-81-4

DprE1-IN-10

DprE1-IN-10 is an inhibitor of Decaprenylphosphoryl-β-D-ribose-2′-epimerase (DprE1), an essential enzyme in the biosynthesis of mycobacterial cell wall components. This compound exhibits strong inhibitory activity against DprE1, making it a valuable tool for researchers studying tuberculosis and exploring potential therapeutic strategies. Its application can lead to significant insights into the mechanisms of mycobacterial infections and the development of antitubercular agents.

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Cat. No.: A49856

CAS No.: 2284580-65-8

Mycobacterium Tuberculosis-IN-2

Mycobacterium Tuberculosis-IN-2 is a potent inhibitor specifically targeting Mycobacterium tuberculosis. Demonstrating effective antimicrobial activity with a minimum inhibitory concentration (MIC) ranging from 0.07 to 0.16 μM, this compound serves as a valuable reagent for tuberculosis research, facilitating studies on pathogen resistance and therapeutic development.

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Cat. No.: A49938

CAS No.: 17615-10-0

IMB-YH-8

IMB-YH-8 is a selective inhibitor of the serine/threonine protein kinase PknB, demonstrating potent antibacterial activity against Mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) of 0.25 µg/mL. This compound is valuable for researchers investigating tuberculosis, providing insights into the mechanisms of bacterial resistance and potential therapeutic strategies. Its targeted action on PknB enhances its relevance in studies aimed at developing new antimicrobial agents.

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Cat. No.: A50368

CAS No.: 1432641-65-0

MmpL3-IN-5

MmpL3-IN-5 is a specific inhibitor of the MmpL3 protein, which plays a critical role in the cell wall biogenesis of Mycobacterium tuberculosis. It demonstrates significant antitubercular activity, exhibiting a pMIC of 7.0 μM against the H37Rv strain of Mycobacterium tuberculosis. This compound is valuable for research focused on the development of new therapeutic strategies for tuberculosis.

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Cat. No.: A50545

CAS No.: 793729-44-9

Tuberculosis inhibitor 12

Tuberculosis Inhibitor 12 is an oxadiazole derivative designed to inhibit Mycobacterium tuberculosis. At a concentration of 20 µM, it demonstrates significant inhibition rates of 82% and 78% in 7H9-Tw-OADC media. This compound serves as a valuable tool for research applications aimed at studying tuberculosis and discovering novel therapeutic strategies.

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1 mg

$30.00

5 mg

$65.00

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