Mycobacterium tuberculosis | Adooq Bioscience

Cat. No.: A49065

CAS No.: 2413974-53-3

Mt KARI-IN-4

Mt KARI-IN-4 is a potent inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), with a Ki value of 5.48 μM. This compound demonstrates significant inhibitory activity against Mtb H37Rv, exhibiting a minimum inhibitory concentration (MIC) of 0.78 μM. Additionally, Mt KARI-IN-4 shows low cytotoxicity in HEK cells, with an IC50 greater than 72 μg/mL, making it a promising candidate for further research in tuberculosis therapeutics.

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Cat. No.: A49073

CAS No.: 2306039-13-2

Mtb-IN-4

Mtb-IN-4 is an isoxazole compound that targets Mycobacterium tuberculosis (Mtb) with an IC50 of 0.70 μM. It effectively inhibits Mtb respiration and biofilm formation within macrophages, making it a valuable tool for studying tuberculosis. Additionally, Mtb-IN-4 enhances the activity of the antibiotic isoniazid against isoniazid-resistant Mtb mutants, providing insights into new therapeutic strategies for combating drug-resistant tuberculosis.

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Cat. No.: A49112

CAS No.: 2413974-69-1

Mt KARI-IN-5

Mt KARI-IN-5 is a potent inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), exhibiting a Ki value of 4.72 μM. This compound demonstrates significant inhibitory activity against Mtb H37Rv, with a minimum inhibitory concentration (MIC) of 1.56 μM, while exhibiting low cytotoxicity in HEK cells (IC50 > 64 μg/mL). Mt KARI-IN-5 is a valuable tool for research into tuberculosis treatment and the exploration of metabolic pathways in pathogenic mycobacteria.

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Cat. No.: A49141

CAS No.: 912780-51-9

C215

C215 is a potent inhibitor of MmpL3, serving as an anti-infection agent. It exhibits significant activity against Mycobacterium tuberculosis, demonstrating an IC90 of 16 μM, alongside effective performance against M. tuberculosis within macrophages. C215 displays limited non-specific toxicity towards mammalian cells, making it a valuable tool for research in tuberculosis treatment and related infectious disease studies.

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Cat. No.: A49170

CAS No.: 3105177-29-2

MSU-44147

MSU-44147 is a selective MmpL3 inhibitor with potent antimicrobial activity against Mycobacterium abscessus. This compound effectively reduces trehalose dimycolate levels by disrupting MmpL3 function, impairing biofilm formation, and decreasing the viability of the bacteria, including intracellular strains. With low cytotoxicity to eukaryotic cells and a narrow antimicrobial spectrum, MSU-44147 is ideal for research on multidrug-resistant mycobacterial infections and can exhibit additive or synergistic effects when combined with other antibiotics.

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Cat. No.: A49187

CAS No.: 1639438-67-7

MmpL3-IN-3

MmpL3-IN-3 is a specific inhibitor of the MmpL3 protein, a vital target in the treatment of tuberculosis. It demonstrates a minimum inhibitory concentration (MIC) of 0.1 μM against the Mycobacterium tuberculosis strain H37Rv, indicating potent anti-tubercular activity. Additionally, MmpL3-IN-3 exhibits favorable metabolic stability in mouse liver microsomes, making it a valuable tool for research focused on tuberculosis therapeutics.

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Cat. No.: A49226

CAS No.: 3035894-73-3

PptT-IN-2

PptT-IN-2 is a potent inhibitor of phosphopantetheinyl transferase (PptT), exhibiting an IC50 value of 2.5 μM. PptT is a critical enzyme involved in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. This compound is valuable for research into tuberculosis, particularly in studies focusing on the therapeutic modulation of lipid biosynthesis and virulence factor expression.

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Cat. No.: A49237

CAS No.: 1364914-72-6

LeuRS-IN-1

LeuRS-IN-1 is a selective inhibitor of Mycobacterium tuberculosis leucyl-tRNA synthetase (M.tb LeuRS) with high potency, exhibiting an IC50 value of 0.06 μM. It also demonstrates a Kd of 0.075 μM for M.tb LeuRS, making it a valuable tool for studying bacterial protein synthesis. Additionally, LeuRS-IN-1 inhibits human cytoplasmic leucyl-tRNA synthetase with an IC50 of 38.8 μM and affects protein synthesis in HepG2 cells (EC50=19.6 μM), highlighting its potential for research into both microbial and human protein synthesis pathways.

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Cat. No.: A49264

CAS No.: 2987482-25-5

MtTMPK-IN-7

MtTMPK-IN-7 is an inhibitor that specifically targets M. tuberculosis thymidylate kinase (MtbTMPK) with an IC50 value of 47 μM. This compound demonstrates sub-micromolar activity against mycobacterial strains, with minimal cytotoxicity (MICs of 2.3 to 4.7 μM). MtTMPK-IN-7 is a valuable tool for research applications focused on tuberculosis and the development of novel antimycobacterial therapies.

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Cat. No.: A49285

CAS No.: 2948309-57-5

PptT-IN-4

PptT-IN-4 is a potent inhibitor of PptT, with an IC50 value of 0.71 μM. This compound effectively inhibits Mycobacterium tuberculosis strain H37Rv, displaying a minimum inhibitory concentration (MIC) of 42 μM. Additionally, PptT-IN-4 shows inhibitory activity on hERG, hCav1.2, and hNav1.5 ion channels, with respective IC50 values of 11 μM, 8.1 μM, and 6.9 μM. This makes PptT-IN-4 significant for research in tuberculosis treatment and cardiovascular safety pharmacology.

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Cat. No.: A49311

CAS No.: 55648-39-0

4-Hydroxyoxyphenbutazone

4-Hydroxyoxyphenbutazone is a potent inhibitor of Mycobacterium tuberculosis (Mtb), demonstrating efficacy against both replicating and nonreplicating forms, including strains resistant to conventional treatments. This compound significantly reduces cytokine production, exhibiting immunosuppressive properties that can be leveraged in research related to rheumatoid arthritis and other inflammatory conditions. Its unique mechanism makes it a valuable tool for exploring therapeutic strategies against Mtb and associated diseases.

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Cat. No.: A49331

CAS No.: 2219338-48-2

Polyketide synthase 13-IN-2

Polyketide Synthase 13-IN-2 is a specific inhibitor of polyketide synthase 13, targeting Mycobacterium tuberculosis. It demonstrates significant biological activity with a minimum inhibitory concentration (MIC) of 0.25 μg/mL. This compound is valuable for research applications focusing on tuberculosis treatment and the study of polyketide synthase function in pathogenic bacteria.

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Cat. No.: A49358

CAS No.: 3052302-61-8

Mtb-IN-3

Mtb-IN-3 is a selective inhibitor of Mycobacterium tuberculosis (Mtb), exhibiting potent in vitro antimycobacterial activity with an absence of cytotoxic effects. This compound demonstrates effectiveness in reducing colony-forming units in the spleen within murine models of tuberculosis. Mtb-IN-3 serves as a valuable tool for research into antimycobacterial therapies and the mechanisms underlying tuberculosis infection.

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Cat. No.: A49359

CAS No.: 1839081-05-8

BTZ-N3

BTZ-N3 is a potent reversible and noncovalent inhibitor of decaprenylphosphoryl-β-d-ribose 2′ oxidase (DprE1), a key enzyme in mycobacterial cell wall synthesis. This compound exhibits significant anti-tuberculosis activity, making it valuable for research focused on combating mycobacterial infections. Its inhibitory effects on DprE1 contribute to the exploration of new therapeutic strategies against tuberculosis.

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Cat. No.: A49369

CAS No.: 500015-22-5

PknB-IN-2

PknB-IN-2 is an inhibitor of Mycobacterium tuberculosis protein kinase B (PknB) with an IC50 value of 12.1 μM. This compound exhibits significant biological activity, making it a valuable tool in the study of tuberculosis pathogenesis and treatment strategies. Research applications include investigations into the role of PknB in bacterial survival and growth, as well as the development of new therapeutic agents targeting tuberculosis.

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Cat. No.: A49378

CAS No.: 121041-20-1

Tuberculosis inhibitor 7

Tuberculosis Inhibitor 7 (compound 2d) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative, specifically targeting Mycobacterium tuberculosis and Mycobacterium marinum. This compound demonstrates significant antibacterial activity, exhibiting a minimum inhibitory concentration (MIC90) of 0.63 μM against both strains. It is a valuable tool for research into tuberculosis treatment and for studying mechanisms of drug resistance.

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Cat. No.: A49450

CAS No.: 2987760-64-3

Mt KARI-IN-1

Mt KARI-IN-1 is a potent inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) with a Ki value of 3.06 μM. This compound demonstrates significant potential in the study of tuberculosis by effectively disrupting essential metabolic pathways in the bacterium. Its inhibitory activity positions Mt KARI-IN-1 as a valuable tool for research aimed at developing new therapeutic strategies against Mycobacterium tuberculosis.

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Cat. No.: A49456

CAS No.: 3035894-87-9

PptT-IN-3

PptT-IN-3 is a selective inhibitor of phosphopantetheinyl phosphoryl transferase (PptT), exhibiting an IC50 of 3.5 μM. PptT is a vital enzyme involved in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. This compound is a valuable tool for investigating tuberculosis pathogenesis and developing novel therapeutic strategies.

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Cat. No.: A49462

CAS No.: 2799607-80-8

MtTMPK-IN-3

MtTMPK-IN-3 is a potent inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtTMPK), exhibiting an IC50 value of 0.12 μM. It demonstrates effective inhibitory activity against Mtb H37Rv with a minimum inhibitory concentration (MIC) of 12.5 μM. Additionally, MtTMPK-IN-3 displays certain cytotoxic effects in human fibroblast cells (MRC-5) with an EC50 of 12.5 μM. This compound is suitable for research focused on tuberculosis and related therapeutic strategies.

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Cat. No.: A49489

CAS No.: 924871-27-2

Mtb-IN-9

Mtb-IN-9 (Compound M1) is a selective inhibitor targeting MtbFadD32 and MtbFadD28, enzymes critical for Mycobacterium tuberculosis survival. This compound effectively reduces Mtb survival within infected macrophages and diminishes the bacterial load and tubercular granulomas in a chronic infection model using BALB/c mice. Mtb-IN-9 holds significant promise for research applications focused on tuberculosis and its underlying mechanisms.

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Cat. No.: A49560

CAS No.: 2987299-68-1

MtTMPK-IN-9

MtTMPK-IN-9 is a selective inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtbTMPK) with an IC50 value of 48 μM. This compound exhibits sub-micromolar antibacterial activity against mycobacterial strains, with minimum inhibitory concentrations (MICs) ranging from 6.25 to 9.4 μM, while demonstrating low cytotoxicity in mammalian cells. MtTMPK-IN-9 is a valuable tool for research into tuberculosis and the development of new therapeutic strategies targeting MtbTMPK.

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Cat. No.: A49580

CAS No.: 57343-54-1

DQn-1

DQn-1 is a potent antifolate that specifically targets Mycobacterium tuberculosis (Mtb) through the inhibition of dihydrofolate reductase (DHFR) enzyme activity. It exhibits a minimum inhibitory concentration (MIC90) of 0.03 µM against Mtb, while demonstrating IC50 values of 8.7 nM and 7.6 nM for Mtb and human DHFR, respectively. This selectivity highlights its potential for use in research focused on tuberculosis treatment and the mechanisms of antifolate drug action.

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Cat. No.: A49603

CAS No.: 2221801-50-7

Polyketide synthase 13-IN-3

Polyketide synthase 13-IN-3 is a potent inhibitor of polyketide synthase 13, showing a minimum inhibitory concentration (MIC) of 0.0625-0.125 μg/mL against the Mycobacterium tuberculosis strain H37Rv. This compound is valuable for research aimed at understanding the mechanisms of antibiotic resistance and exploring novel therapeutic strategies against tuberculosis. Its selective inhibition may provide insights into polyketide biosynthesis and its implications in microbial pathogenesis.

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Cat. No.: A49657

CAS No.: 1197343-17-1

(E,Z)-Platanoside

(E,Z)-Platanoside is a flavonoid glycoside that acts as a potent and highly selective inhibitor of Methicillin-resistant Staphylococcus aureus (MRSA). Demonstrating minimal activity against other strains, including Gram-negative bacteria, intracellular Mycobacterium intracellulare, and various fungi such as Candida albicans and Aspergillus fumigatus, it offers targeted antibacterial effects. This compound is valuable for research applications focused on MRSA infections and the development of new antimicrobial therapies.

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Cat. No.: A49692

CAS No.: 141353-07-3

Tuberculosis inhibitor 8

Tuberculosis Inhibitor 8, a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative, targets Mycobacterium tuberculosis and demonstrates potent antibacterial activity with a minimum inhibitory concentration (MIC90) of 0.69 μM against both Mycobacterium tuberculosis and Mycobacterium marinum. This compound serves as a valuable tool for research applications focused on the development of novel therapeutic strategies for tuberculosis. Its efficacy against resistant strains makes it significant for studying mycobacterial infections and drug resistance mechanisms.

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