Impurities & Reference Standards

Cat. No.

A68532

CAS No.

186694-45-1

(R)-Eslicarbazepine acetate

Synonyms: BIA 2-059; (R)-Licarbazepine acetate

(R)-Eslicarbazepine acetate is the R-enantiomer of Eslicarbazepine acetate, which functions primarily as an antiepileptic agent. This compound acts as a dual inhibitor of β-Secretase and voltage-gated sodium channels, contributing to its therapeutic efficacy in controlling seizures. It serves as a valuable tool for research in epilepsy and neurodegenerative disorders.

Cat. No.

A69449

CAS No.

2758817-06-8

DG013B

DG013B is an epimer of DG013A, primarily studied for its role as a negative control in binding assays. This compound exhibits weak affinity for endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2, thereby aiding in the investigation of the binding properties of DG013A and its analogues to these targets. Researchers can utilize DG013B to better understand the mechanisms of peptide processing and presentation in various biological contexts.

Cat. No.

A69698

CAS No.

194-59-2

7H-Dibenzo[c,g]carbazole

Synonyms: DBC

7H-Dibenzo[c,g]carbazole (DBC) is an azaarene known for its strong carcinogenic properties. It induces the formation of DNA adducts in various biological systems, including fish and human diploid fibroblasts, and is associated with the production of micronuclei in human blood lymphocytes. The compound's activation by cytochrome P450 enzymes primarily generates phenolic metabolites, making it a relevant tool for studying mechanisms of carcinogenesis and DNA damage in chemical research.

Cat. No.

A69938

CAS No.

118949-22-7

(Rac)-Vorozole

Synonyms: (Rac)-R83842

(Rac)-Vorozole is a racemic mixture of Vorozole, a potent and selective non-steroidal aromatase inhibitor. This compound effectively inhibits the aromatase enzyme, which is crucial for estrogen biosynthesis, making it valuable in the research of hormone-dependent conditions such as breast cancer. Its oral bioavailability enhances its utility in preclinical studies investigating the modulation of estrogen levels for therapeutic applications.

Cat. No.

A70031

CAS No.

5988-19-2

L-Dihydroorotic acid

L-Dihydroorotic acid is a key intermediate in orotic acid metabolism and a substrate for dihydroorotate dehydrogenase (DHODH). It plays a critical role in the de novo synthesis of pyrimidines and is involved in cellular proliferation and differentiation. This compound is essential for research into metabolic pathways related to nucleotide synthesis and has potential applications in understanding various diseases, including cancer and metabolic disorders.

Cat. No.

A70097

CAS No.

555-16-8

4-Nitrobenzaldehyde

4-Nitrobenzaldehyde is a photodegradation product primarily derived from the antibiotic Chloramphenicol. This compound exhibits genotoxic and mutagenic properties, raising concerns regarding its potential impact on human health and environmental safety. It serves as an important reagent in various research applications, including studies on antibiotic degradation, environmental toxicity assessments, and the evaluation of genotoxic effects in biological systems.

Cat. No.

A70154

CAS No.

148554-65-8

Seco Rapamycin sodium salt

Synonyms: Secorapamycin A monosodium

Seco Rapamycin sodium salt is the ring-opened derivative of Rapamycin. This compound does not influence the mechanistic target of rapamycin (mTOR) signaling, making it a valuable tool for research focused on alternative pathways. It is utilized in studies investigating the molecular mechanisms of immunosuppression and cellular growth regulation, providing insights into various biological processes.

Cat. No.

A70232

CAS No.

2051-10-7

5,6-Chrysenedione

5,6-Chrysenedione is a photochemical degradation product of 6-Aminochrysene, acting primarily through mechanisms associated with chemical transformation under light exposure. This compound is relevant for research investigating the ecological impacts and degradation processes of polycyclic aromatic hydrocarbons (PAHs). Its study aids in understanding the environmental fate and potential toxicity of related organic pollutants.

Cat. No.

A70238

CAS No.

147438-27-5

Seco Rapamycin

Synonyms: Secorapamycin A

Seco Rapamycin, the ring-opened derivative of Rapamycin, serves as a significant tool in biochemical research. Unlike its parent compound, Seco Rapamycin does not inhibit the mTOR pathway, making it valuable for studies that require mTOR-independent effects. This compound is useful in assessing the biological activities of Rapamycin and exploring alternative pathways influenced by its structural modifications.

Cat. No.

A70346

CAS No.

79573-48-1

Mefox

Mefox is a degradation product of folic acid, primarily involved in the study of folate metabolism and its biochemical pathways. It serves as a valuable compound for researchers investigating the stability and breakdown of folic acid in biological systems. Mefox can be utilized in studies related to nutrition, cellular growth, and various metabolic disorders linked to folate deficiency.

Cat. No.

A70385

CAS No.

56806-74-7

4-Hydroxyphenyl diphenyl phosphate

4-Hydroxyphenyl diphenyl phosphate is a hydroxylated derivative of organophosphate compounds, primarily functioning as a flame retardant. It exhibits significant efficacy in reducing flammability in various materials, making it useful in fireproofing applications. This compound serves as a valuable research tool for studies focused on flame retardancy mechanisms and the environmental impact of organophosphates.

Cat. No.

A70443

CAS No.

24554-26-5

FANFT

FANFT is a potent orally active uroepithelial carcinogen that is metabolized to ANFT in vivo. This compound induces gene mutations and promotes malignant cell transformation, making it a valuable tool for cancer research. Additionally, FANFT has been shown to effectively induce bladder tumors in murine models, facilitating studies on carcinogenesis and tumor progression.

Cat. No.

A70450

CAS No.

2762182-61-4

Ribociclib acetate

Ribociclib acetate is a degradation product of Ribociclib, primarily formed under acid-base hydrolysis conditions. This compound has been identified as potentially carcinogenic, which underscores its relevance in studies of drug safety and metabolic pathways. Its characterization is essential for understanding drug stability and degradation in chemical research applications.

Cat. No.

A70498

CAS No.

173559-73-4

Hydroxysaikosaponin A

Synonyms: Bupleuroside III

Hydroxysaikosaponin A, a degradation product of Saikosaponin A, primarily functions through acid hydrolysis. This compound exhibits key biological activities, including anti-inflammatory and cytotoxic properties. Hydroxysaikosaponin A serves as a valuable tool in research applications focused on investigating the pharmacological effects of saikosaponins and their metabolic pathways.

Cat. No.

A70527

CAS No.

96722-46-2

5-O-Demethyl-28-hydroxy-Avermectin A1a

5-O-Demethyl-28-hydroxy-Avermectin A1a is a degradation product of Avermectin B1a, primarily targeting the modulation of the ectoparasitic and nematocidal activities associated with avermectin compounds. This reagent is important for research applications focused on the biochemical pathways related to avermectin metabolism and its efficacy in agricultural settings. It provides insights into the pharmacokinetics and environmental impact of avermectin derivatives.

Cat. No.

A70545

CAS No.

2742899-98-3

(S)-Dehydro Venlafaxine

(S)-Dehydro Venlafaxine is the S-enantiomer of Dehydro Venlafaxine, an impurity of Venlafaxine hydrochloride. While it lacks direct pharmacological activity, it serves as a valuable reference standard for analytical and research purposes. Dehydro Venlafaxine is known for its role as a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake, making this compound relevant for studies focusing on antidepressant mechanisms and drug development.

Cat. No.

A70561

CAS No.

640-49-3

β-Apo-10'-carotenal

Synonyms: 10'-Apo-β-carotenal

β-Apo-10'-carotenal is a degradation product of β,β-carotene, primarily known for its role in metabolic processes. This compound exhibits significant biological activity related to flavor enhancement and can serve as a valuable tool in flavor research. Its utility extends to studies on carotenoid metabolism and applications in food science.

Cat. No.

A70575

CAS No.

2052-63-3

13-cis-Vitamin A

Synonyms: 13-cis-Vitamin A1; 13-cis-Retinol

13-cis-Vitamin A is the 13-cis-isomer of Vitamin A, an essential compound involved in visual phototransduction and cellular differentiation. This metabolite exhibits significant biological activity, primarily in the modulation of retinoid signaling pathways. It is widely utilized in research applications focusing on retinal function, skin biology, and the effects of retinoids on gene expression and cellular growth.

Cat. No.

A70643

CAS No.

67910-07-0

Homobaldrinal

Homobaldrinal is a decomposition product derived from Valepotriate. This compound has demonstrated genotoxic activity as evidenced by the Salmonella/microsome assay. Due to its biological properties, Homobaldrinal is suitable for research applications focused on genetic toxicity and the assessment of compound safety.

Cat. No.

A70672

CAS No.

53494-70-5

Endrin ketone

Endrin ketone is a degradation product of the insecticide Endrin, recognized for its carcinogenic properties. This compound is primarily studied for its toxicological effects and potential role in cancer research. It provides insight into the metabolic pathways and environmental impact of organochlorine compounds, supporting investigations into their long-term effects on health.

Cat. No.

A70732

CAS No.

61774-58-1

rel-cis-Pinic acid

rel-cis-Pinic acid is an important oxidation product of α-pinene, a significant monoterpene in biogenic emission processes. This compound serves as a useful intermediate in organic synthesis and has implications for studies related to atmospheric chemistry and environmental science. Its role in the oxidative transformation of natural terpenes enhances the understanding of atmospheric reactions and their impact on air quality.

Cat. No.

A70828

CAS No.

56516-72-4

N-Nitrosoglyphosate

N-Nitrosoglyphosate is a nitrosamine degradation product of the herbicide glyphosate. It serves as a valuable compound for studying the environmental fate of glyphosate, particularly in the context of its breakdown and potential toxicological effects. This reagent is essential for research applications aimed at understanding herbicide degradation pathways and evaluating the implications of glyphosate derivatives in ecological and human health assessments.

Cat. No.

A70836

CAS No.

349122-64-1

Zolpyridine

Zolpyridine is a degradation product of zolpidem tartrate, primarily known for its role in the study of drug metabolism. It serves as a significant marker in pharmacokinetic investigations and is useful in understanding the stability and breakdown of zolpidem in biological systems. Researchers can employ Zolpyridine to explore its potential effects and implications in various pharmacological contexts.

Cat. No.

A70907

CAS No.

2707535-88-2

Monohydroxy melphalan hydrochloride

Synonyms: Hydroxymelphalan hydrochloride

Monohydroxy melphalan hydrochloride is a hydrolysis product of Melphalan, targeted for studying the degradation pathways of this chemotherapeutic agent. This compound is formed in aqueous solutions, including cell culture media and human plasma, and serves as a valuable reference for researchers investigating Melphalan metabolism and its biological effects. Its presence is significant in understanding the pharmacokinetics and efficacy of Melphalan in clinical applications.

Cat. No.

A70912

CAS No.

67562-39-4

1,2,3,4,6,7,8-Heptachlorodibenzofuran

Synonyms: 1,2,3,4,6,7,8-HpCDF

1,2,3,4,6,7,8-Heptachlorodibenzofuran is a dioxin-like polychlorinated dibenzofuran known for its persistent environmental presence and bioaccumulation potential. It has been detected in diverse biological matrices, including soil near municipal waste incinerators, freshwater fish, and human breast milk, indicating its relevance in toxicological studies. This compound is significant for research focused on environmental contamination, human exposure assessment, and the study of its toxicological effects on living organisms.