Impurities & Reference Standards

Cat. No.

A48597

CAS No.

3075275-82-7

(R)-DS86760016

(R)-DS86760016 is a potent inhibitor of leucyl-tRNA synthetase (LeuRS), specifically the R-enantiomer of the compound DS86760016. This reagent exhibits significant antimicrobial activity against multidrug-resistant Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. It is essential for research applications focused on combating antibiotic resistance and studying bacterial protein synthesis.

Cat. No.

A48879

CAS No.

135745-46-9

Thermopterin

Thermopterin is a derivative of the antimicrobial agent Pterin, derived from Methanoculleus thermophilus. This compound exhibits significant antimicrobial activity, making it a valuable reagent for studies focused on antimicrobial mechanisms and resistance. Thermopterin can be utilized in various biological research applications, including the exploration of microbial physiology and the development of antimicrobial strategies.

Cat. No.

A49393

CAS No.

944-61-6

Tetrachloroveratrole

Tetrachloroveratrole is a biodegradation product resulting from bacterial O-methylation of tri- and tetrachloroguaiacols, which are byproducts generated during the bleaching of wood pulp in the paper manufacturing industry. This compound is significant for research focused on biodegradation processes and environmental microbiology, providing insight into the degradation pathways of chlorinated phenolic compounds. Its study aids in understanding the ecological impacts of industrial pollutants and developing bioremediation strategies.

Cat. No.

A49785

CAS No.

3061155-24-3

ent-Rhizocarpic acid

ent-Rhizocarpic acid is an enantiomer of Rhizocarpic acid, primarily targeting bacterial and parasitic organisms. It demonstrates enhanced antibacterial activity against Staphylococcus aureus (ATCC 25923) and effective antiparasitic effects on Giardia duodenalis 713, surpassing the efficacy of its parent compound. Additionally, ent-Rhizocarpic acid exhibits weak yet selective antitumor activity against NS-1 cells, making it a valuable reagent for various biological research applications.

Cat. No.

A50182

CAS No.

42302-24-9

Dihydropleuromutilin

Dihydropleuromutilin is a reduced derivative of Pleuromutilin, primarily targeting gram-positive bacteria. It exhibits significant antibacterial activity while displaying reduced toxicity compared to its parent compound. This characteristic makes it a valuable reagent for research focused on developing new therapeutic agents against bacterial infections.

Cat. No.

A50321

CAS No.

107334-06-5

(Rac)-PD 138312

(Rac)-PD 138312 is a racemic mixture of PD 138312, a potent and orally active antibacterial agent specifically targeting Gram-positive bacteria. This compound demonstrates significant antibacterial activity, making it a valuable tool for research focused on the mechanisms of bacterial resistance and the development of new therapeutic strategies. Its efficacy against Gram-positive pathogens supports its use in studies aimed at addressing infections caused by these bacteria.

Cat. No.

A50561

CAS No.

64436-13-1

Arsenobetaine

Arsenobetaine is an organoarsenical that functions as a compatible solute. It demonstrates protective effects against Bacillus subtilis cell death induced by high osmolarity and extreme temperatures at a concentration of 1 mM. Arsenobetaine finds applications in research related to marine biology and stress responses in organisms, providing insights into osmoregulation and thermal tolerance mechanisms.

Cat. No.

A51870

CAS No.

256328-82-2

Desthiazolylmethyl ritonavir

Desthiazolylmethyl ritonavir is a degradation product of the HIV protease inhibitor ritonavir, formed through a base-catalyzed mechanism. This compound may be utilized in research to study the stability and degradation pathways of protease inhibitors, contributing to a deeper understanding of drug metabolism and resistance in HIV therapy. Its relevance extends to evaluating the structural integrity and efficacy of antiretroviral agents in therapeutic applications.

Cat. No.

A51892

CAS No.

827591-04-8

GSK984

GSK984 serves as an inactive control probe for GSK983, a well-characterized dihydroorotate dehydrogenase (DHODH) inhibitor known for its antiviral properties. This compound facilitates the understanding of target specificity and mechanism by providing a baseline for comparison in experimental setups. Researchers can utilize GSK984 to validate findings related to DHODH inhibition and its implications in antiviral research.

Cat. No.

A52308

CAS No.

55375-92-3

D-Praziquanamine

Synonyms: (-)-Praziquanamine

D-Praziquanamine is an isomer of L-Praziquanamine, serving as a useful experimental control in research applications. This compound provides a means to investigate the pharmacological properties of its counterpart and allows for a comparative analysis of biological activity. Researchers may utilize D-Praziquanamine to gain insights into the structure-activity relationship of natural products and their derivatives.

Cat. No.

A52336

CAS No.

2650846-59-4

OSM-S-106

OSM-S-106 is a pro-inhibitor targeting PfAsnRS, with its inhibition mechanism involving the enzyme-mediated formation of an Asn-OSM-S-106 adduct. This compound effectively inhibits protein translation and induces an amino acid starvation response. Demonstrating selective activity against both Plasmodium blood and liver stages, OSM-S-106 also exhibits low intrinsic clearance in human microsomes, making it a valuable tool for malaria research and studies focused on amino acid metabolism.

Cat. No.

A52453

CAS No.

6292-62-2

(E/Z)-4,4'-Dicyanostilbene

(E/Z)-4,4'-Dicyanostilbene is an isomer of 4,4'-Dicyanostilbene, serving as an important experimental control in research. This compound demonstrates potent antimalarial activity against the Dd2 strain, with an EC50 value of 27 nM. Additionally, it exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA), making it relevant for studies in infectious disease and drug resistance.

Cat. No.

A52669

CAS No.

86630-81-1

(R)-Meclonazepam

Synonyms: Ro 11-3624; Ro 11-3624/001

(R)-Meclonazepam is the inactive enantiomer of Meclonazepam, a benzodiazepine derivative. While (R)-Meclonazepam itself does not exhibit significant pharmacological activity, Meclonazepam has been noted for its anti-schistosomiasis potential. This compound serves as a valuable tool for research applications focused on the study of benzodiazepine enantiomers and their biological effects.

Cat. No.

A52982

CAS No.

28281-49-4

3,4-Methylenedioxypropiophenone

3,4-Methylenedioxypropiophenone is an isomer of 3,4-methylenedioxyphenyl-2-propanone, primarily targeting intracellular pathogens. This compound exhibits significant biological activity against Leishmania species, making it valuable in parasitology research and drug development studies focusing on leishmaniasis. Its efficacy in inhibiting the growth of these pathogens contributes to the exploration of therapeutic options for infectious diseases.

Cat. No.

A53779

CAS No.

1422180-61-7

(7R)-SBP-0636457

Synonyms: (7R)-SBI-0636457; (7R)-SB1-0636457

(7R)-SBP-0636457 is an isomer of the SMAC mimetic SBP-0636457 and serves as an important experimental control. This compound functions as an inhibitor of inhibitor of apoptosis proteins (IAPs) by binding to their BIR domains, exhibiting a binding affinity (Ki) of 0.27 μM. It is primarily utilized in research focused on solid tumors and hematologic malignancies, contributing to the understanding of cancer therapies that exploit apoptosis pathways.

Cat. No.

A53801

CAS No.

189-55-9

Dibenzo(a,i)pyrene

Dibenzo(a,i)pyrene is a polycyclic aromatic hydrocarbon that serves as a carcinogenic ligand for the TCDD (Ah) receptor. It has been shown to induce DNA adduct formation while upregulating p53 and p21WAF1 protein levels in diploid lung fibroblasts. Additionally, Dibenzo(a,i)pyrene alters cell cycle dynamics, increasing the S phase population and leading to G0/G1 and G2/M phase decreases, resulting in S phase delay or arrest. This compound is relevant for applications in cancer research.

Cat. No.

A53822

CAS No.

2459946-14-4

(3S,5S,6R)-Navtemadlin

Synonyms: (3S,5S,6R)-AMG 232; (3S,5S,6R)-KRT-232

(3S,5S,6R)-Navtemadlin serves as an isomeric control for Navtemadlin, a potent and selective inhibitor of the p53-MDM2 interaction. With an IC50 value of 0.6 nM, Navtemadlin demonstrates high affinity for MDM2, as evidenced by its Kd of 0.045 nM. This reagent is valuable for research applications aimed at understanding the modulation of p53 pathways and exploring potential therapeutic strategies for cancers with disrupted p53 functions.

Cat. No.

A53920

CAS No.

64419-92-7

Necrostatin-1 (inactive control)

Synonyms: Nec-1 (inactive control)

Necrostatin-1 (inactive control) is an inactive analog of the potent necroptosis inhibitor Necrostatin-1. This compound serves as a negative control in research studies involving necroptosis mechanisms, allowing for the differentiation between specific and non-specific effects in cellular assays. It is crucial for validating experimental results and ensuring the reliability of data related to necroptosis and cell death pathways.

Cat. No.

A54008

CAS No.

153538-08-0

(Rac)-Plevitrexed

Synonyms: (Rac)-ZD 9331; (Rac)-BGC9331

(Rac)-Plevitrexed is a potent inhibitor of thymidylate synthase (TS) and serves as a racemic mixture of Plevitrexed. This compound exhibits significant biological activity in cancer research due to its ability to impede DNA synthesis by disrupting folate metabolism. Additionally, (Rac)-Plevitrexed features an alkyne group, enabling its application in click chemistry for copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool for bioconjugation and labeling studies in biochemical research.

Cat. No.

A54401

CAS No.

437982-90-6

(R)-PHA533533

(R)-PHA533533 is the inactive enantiomer of (S)-PHA533533, which acts as a cyclin-dependent kinase 2 (CDK2) inhibitor with identified antitumor activity. This compound serves as a necessary control in biochemical assays aimed at studying the specific effects of the active enantiomer on cell proliferation and cancer progression. Research utilizing (R)-PHA533533 can provide insights into the stereospecificity and selectivity of CDK2 inhibitors in cancer therapy.

Cat. No.

A56930

CAS No.

1996673-44-9

(Rac)-IBR120

(Rac)-IBR120 is a racemic mixture of IBR120, a potent inhibitor of RAD51. This compound exhibits significant growth inhibition in MDA-MB-468 cells, making it a valuable tool for studying aggressive cancer types, particularly triple-negative breast cancer. Researchers can utilize (Rac)-IBR120 to explore therapeutic strategies targeting DNA repair mechanisms in challenging malignancies.

Cat. No.

A57743

CAS No.

858186-27-3

4-Aminonaphthalen-1-yl acetate

4-Aminonaphthalen-1-yl acetate serves as a negative control for lysine acetyltransferase KAT8. This 4-amino-1-naphthol derivative exhibits no inhibitory activity against KAT8, making it a useful tool for validating experimental results in acetylation studies. Its role as a control reagent allows researchers to distinguish between specific and non-specific effects in biochemical assays involving KAT8.

Cat. No.

A58105

CAS No.

64657-18-7

1,9-Dideoxyforskolin

1,9-Dideoxyforskolin is an inactive analog of forskolin, primarily targeting adenylate cyclase. Due to its structural similarity, it serves as a valuable tool in research to study forskolin's mechanisms of action without activating downstream signaling pathways. This compound is useful for investigations into cellular processes mediated by cyclic AMP and in exploring the regulatory roles of adenylate cyclase in various biological contexts.

Cat. No.

A58901

CAS No.

28553-12-0

Diisononyl phthalate

Synonyms: DINP

Diisononyl phthalate (DINP) functions primarily as a plasticizer, enhancing the flexibility and durability of various polymers. Research indicates that DINP can induce an increase in blood pressure through the activation of the ACE/AT1R signaling pathway while inhibiting nitric oxide production in murine models. Its applications extend to resin solvents, building materials, lubricants, adhesives, cosmetics, and printing inks, making it valuable for diverse industrial and research purposes.

Cat. No.

A59086

CAS No.

1212421-96-9

(S)-TXNIP-IN-1

(S)-TXNIP-IN-1 is the less active S-enantiomer of the TXNIP-TRX complex inhibitor TXNIP-IN-1. This compound is primarily utilized in research focused on metabolic disorders associated with TXNIP-TRX interactions, such as diabetes, cardiovascular diseases, and inflammatory conditions. Its role in modulating the TXNIP-TRX complex makes it a valuable reagent for investigating the underlying mechanisms of these diseases.