Elastases

Cat. No.

A14073

CAS No.

150374-95-1

Sivelestat sodium salt

Synonyms: ONO-5046

Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. It inhibits NF-kB activation and LTB4-induced neutrophil transmigration in vitro.

Cat. No.

A11390

CAS No.

157341-41-8

DMP 777

Synonyms: L-694458

DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

Cat. No.

A13303

CAS No.

171964-73-1

ZD-0892

ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.

Cat. No.

A14184

CAS No.

127373-66-4

Sivelestat

Synonyms: Elastase Inhibitor IV

Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase).

Cat. No.

A14912

CAS No.

111682-13-4

Elastase Inhibitor

Elastase Inhibitor is a potent, irreversible inhibitor of human neutrophil elastase (HNE).

Cat. No.

A14913

CAS No.

65144-34-5

Elastase Inhibitor, SPCK

Elastase Inhibitor, SPCK is a potent, irreversible inhibitor of human leukocyte elastase (HLE) (Ki = 10 uM).

Cat. No.

A15315

CAS No.

344930-95-6

SSR 69071

SSR 69071 is a high affinity, potent inhibitor of Neutrophil Elastase (human leukocyte elastase, HLE) (IC50 = 3.9 nM).

Cat. No.

A16137

CAS No.

201677-61-4

Sivelestat sodium hydrate (ONO-5046 sodium hydrate)

Synonyms: ONO5046-Na; EI546 sodium; LY544349 sodium

Sivelestat sodium is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.

Cat. No.

A16866

CAS No.

675103-36-3

BAY-678

BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

Cat. No.

A17841

CAS No.

7512-17-6

N-Acetylglucosamine

Synonyms: Acetylglucosamine; GlcNAc; Bio-NAG; GreenNAG; Marine Sweet; N-Acetyl-D-glucosamine; NSC 400525; NSC 524344.

Acetylglucosamine or N-acetylglucosamine is potentially for the treatment of irritable bowel syndrome. N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. GlcNAc has been reported to be an inhibitor of elastase release from human polymorphonuclear leukocytes (range 8–17% inhibition), however this is much weaker than the inhibition seen with N-acetylgalactosamine (range 92–100%).

Cat. No.

A19564

CAS No.

675103-35-2

BAY-678 racemate

BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

Cat. No.

A19838

CAS No.

2117404-84-7

BAY-677

BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM.

Cat. No.

A20510

CAS No.

111149-90-7

Lodelaben

Synonyms: SC-39026; Declaben

Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.

Cat. No.

A20645

CAS No.

1161921-82-9

BAY-85-8501

BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM.

Cat. No.

A20788

CAS No.

291778-77-3

AE-3763

AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.

Cat. No.

A22033

CAS No.

198062-54-3

GW311616

GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 nM.

Cat. No.

A22107

CAS No.

126062-19-9

JCP174

JCP174 is a depalmitoylase inhibitor that enhances Toxoplasma host-cell invasion by targeting TgPPT1.

Cat. No.

A46466

CAS No.

15015-57-3

Elastase-IN-3

Elastase-IN-3 is a potent inhibitor of elastase, an enzyme produced by Pseudomonas aeruginosa. By specifically targeting the LasR protein with a KD value of 7.04 µM, Elastase-IN-3 disrupts the quorum sensing system, thereby inhibiting the bacterial communication crucial for virulence and biofilm formation. This compound has significant applications in biodefense, food safety, and antibacterial research, particularly in studying the impact of Pseudomonas aeruginosa on food spoilage and related infections.

Cat. No.

A66450

CAS No.

99453-84-6

Neltenexine

Neltenexine is a potent elastase inhibitor that reduces anion secretion in bronchial epithelial cells. It achieves this by inhibiting chloride and bicarbonate uptake through the Na+/K+/2Cl- and Na+/HCO3- cotransporters, while not affecting the CFTR channel. Additionally, it can stimulate the chloride/bicarbonate exchanger, contributing to its mucolytic effects. Research indicates that Neltenexine effectively prevents pulmonary emphysema and reduces alveolar deformation in elastase-induced rat models, making it a valuable tool for studying lung diseases such as chronic obstructive pulmonary disease (COPD).

Cat. No.

A71026

CAS No.

197890-44-1

GW311616 hydrochloride

Synonyms: GW311616A

GW311616 hydrochloride is a selective inhibitor of human neutrophil elastase (HNE), demonstrating potent activity with an IC50 value of 22 nM and a Ki value of 0.31 nM. This compound exhibits oral bioavailability and extended duration of action, making it a valuable tool for studying the role of HNE in various inflammatory diseases. Research applications include the investigation of HNE's involvement in tissue remodeling and acute lung injury.

Cat. No.

A71028

CAS No.

144055-55-0

FK706

FK706 is a potent competitive inhibitor of human neutrophil elastase, exhibiting an IC50 of 83 nM and a Ki of 4.2 nM. This compound effectively inhibits both mouse neutrophil elastase and porcine pancreatic elastase, with IC50 values of 22 nM and 100 nM, respectively. Importantly, FK706 shows selectivity by not inhibiting other serine proteinases, including human pancreatic trypsin and α-chymotrypsin. Due to its anti-inflammatory properties, FK706 is valuable for research related to inflammatory diseases and conditions associated with elastase activity.

Cat. No.

A71030

CAS No.

1448314-31-5

Neutrophil elastase inhibitor 1

Neutrophil elastase inhibitor 1 is a competitive, pseudoirreversible inhibitor primarily targeting neutrophil elastase. With an IC50 value of 7 nM, it effectively modulates elastase activity, making it a valuable tool in the study of inflammatory diseases where neutrophil activation plays a crucial role. This compound can facilitate research into therapeutic interventions for conditions characterized by excessive elastase activity.

Cat. No.

A71031

CAS No.

2446175-39-7

(R)-BAY-85-8501

(R)-BAY-85-8501 is the less active enantiomer of BAY-85-8501, a selective and potent inhibitor of Human Neutrophil Elastase (HNE) with an IC50 of 65 pM. This compound is utilized in research to investigate the role of HNE in various inflammatory conditions and to explore therapeutic strategies targeting this enzyme. Its specific inhibitory action makes it a valuable tool for studying neutrophil function and related diseases.

Cat. No.

A71033

CAS No.

906547-89-5

Lonodelestat

Synonyms: POL6014

Lonodelestat is a selective, orally active peptide inhibitor of human neutrophil elastase (hNE). This compound exhibits significant potential for the study of cystic fibrosis (CF) by modulating the activity of hNE, a key enzyme implicated in inflammatory responses and tissue damage in CF patients. It serves as a valuable tool for investigating therapeutic strategies aimed at mitigating the effects of excessive neutrophil activity in pulmonary diseases.

Cat. No.

A71034

CAS No.

182073-77-4

ZD8321

ZD8321 is a potent inhibitor of human neutrophil elastase (NE), demonstrating an inhibition constant (Ki) of 13±1.7 nM. This compound effectively modulates elastase activity, making it valuable in research focused on inflammatory diseases and tissue remodeling. ZD8321 is suitable for studies investigating the role of elastase in various pathological conditions and therapeutic interventions.