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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
CRBN ligand-222 is a small molecule ligand that selectively targets the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the formation of Proteolysis Targeting Chimeras (PROTACs). This compound is valuable for research applications in targeted protein degradation and the investigation of ubiquitin-mediated pathways.
CRBN ligand-309 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of CRBN to specific proteins. This compound can be employed in the synthesis of PROTACs (Proteolysis Targeting Chimeras) by linking it to a ligand specific for a target protein. CRBN ligand-309 is valuable for studying protein degradation pathways and developing targeted therapeutic strategies in cancer research and other diseases.
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NH2-MeO-Ph-amide-(2,6-Dioxo-3-Pip) is a ligand that targets Cereblon (CRBN), a key component of the E3 ubiquitin ligase complex. This compound facilitates the synthesis of PROTAC BRD4 Degrader-22, enabling targeted degradation of the BRD4 protein. Its applications include research in the field of protein degradation and regulation of gene expression, providing a valuable tool for studying the role of BRD4 in various biological processes.
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Desamino lenalidomide-4-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein, making it a valuable tool for protein degradation studies. Desamino lenalidomide-4-COOH can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs for targeted protein modulation in various research applications.
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CRBN ligand-700 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). It is suitable for research applications focused on targeted protein degradation and the exploration of CRBN-mediated pathways in cellular processes.
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CRBN ligand-432 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). It is used in biological research to probe targeted protein degradation pathways, enabling studies on therapeutic applications in diseases involving dysregulated protein levels.
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Desamino lenalidomide-4-acetonitrile functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted degradation processes. This compound can be conjugated to a target protein ligand through a linker to create bifunctional molecules known as PROTACs. It is valuable in research applications focusing on targeted protein degradation, molecular biology, and therapeutic development.
CRBN ligand-415 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound is designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras) by linking to specific target protein ligands via a suitable linker. Its utility in research includes the development of targeted protein degradation strategies, enabling the selective modulation of cellular protein levels for therapeutic intervention.
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CRBN ligand-738 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to create a proteolysis targeting chimera (PROTAC) by linking it to a target protein ligand through a suitable linker. CRBN ligand-738 is valuable for studies exploring targeted protein degradation and ubiquitin-proteasome system modulation in various biological contexts.
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CRBN ligand-598 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). Its application in targeted protein degradation offers valuable insights into protein function and therapeutic development in various disease models.
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CRBN ligand-324 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis targeting chimera). CRBN ligand-324 is valuable for studying targeted protein degradation and its applications in therapeutic research and development.
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CRBN ligand-277 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to target proteins. This compound is designed for use in the development of PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of specific proteins within cellular systems. Its application is crucial for studies aimed at understanding proteostasis and therapeutic strategies in diseases linked to protein dysregulation.
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CRBN ligand-326 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. It is a valuable tool for investigating protein regulation and has potential applications in therapeutic development and protein homeostasis studies.
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CRBN ligand-367 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be utilized in the design of Proteolysis Targeting Chimeras (PROTACs) when linked to a target protein ligand through a suitable linker. CRBN ligand-367 is essential for studies involving targeted protein degradation and the modulation of protein function within cellular contexts.
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CRBN ligand-505 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimeras). It is particularly useful in research focused on selective elimination of proteins, offering insights into cellular mechanisms and potential therapeutic interventions.
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CRBN ligand-410 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon to target proteins. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-410 is instrumental in research applications focused on targeted degradation of proteins, enabling studies in cancer biology, immunology, and cellular regulation.
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CRBN ligand-532 is an effective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling specific degradation of target proteins. It serves as a valuable tool for studies in targeted protein degradation and related therapeutic applications.
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CRBN Ligand-754 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a suitable linker to create a proteolysis-targeting chimeric (PROTAC) molecule. CRBN Ligand-754 is useful in studies aimed at exploring targeted protein degradation mechanisms and can serve as a valuable tool in drug discovery and therapeutic research.
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CRBN ligand-249 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of PROTACs (Proteolysis Targeting Chimeras). Its application in research underscores the potential for innovative therapeutic strategies in targeted manipulation of protein levels within cellular systems.
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CRBN ligand-520 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the engagement of CRBN with target proteins. This compound can be conjugated to a ligand of interest through a linker, enabling the formation of a PROTAC (PROteolysis TArgeting Chimeras). CRBN ligand-520 is utilized in studies focused on targeted protein degradation and the modulation of protein homeostasis, thereby contributing to the advancement of therapeutic strategies in various diseases.
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CRBN ligand-445 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), enabling the selective degradation of specific proteins. Its application in targeted protein degradation research makes it a valuable tool in studies of cellular regulation and therapeutic development.
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CRBN ligand-621 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), actively facilitating the recruitment of the cereblon protein. This compound can be utilized to link a target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). Its application in targeted protein degradation research makes CRBN ligand-621 a valuable tool for studying protein regulation and function in various biological contexts.
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C5 Lenalidomide-6-fluoro is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound serves as a crucial component in the development of PROTACs, allowing the targeted degradation of specific proteins. Its applications in chemical biology and drug discovery include the modulation of protein levels and the investigation of ubiquitin-proteasome system pathways.
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CRBN ligand-425 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment in cellular processes. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), enabling targeted protein degradation. CRBN ligand-425 is valuable for research applications in drug development, particularly in the study of disease mechanisms and therapeutic strategies involving the ubiquitin-proteasome system.
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CRBN ligand-517 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be effectively conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). This reagent is instrumental in targeted protein degradation studies and offers valuable insights into protein regulation pathways.
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