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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
CRBN ligand-235 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-235 is valuable for research in targeted protein degradation and elucidation of ubiquitin-proteasome system mechanisms.
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CRBN ligand-320 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC that promotes the ubiquitination and subsequent degradation of the target protein. CRBN ligand-320 serves as a valuable tool for research in targeted protein degradation and cellular protein regulation.
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CRBN ligand-286 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound enables the development of Proteolysis Targeting Chimeras (PROTACs) by linking to a target protein ligand through a suitable linker. CRBN ligand-286 is essential for studies focused on targeted protein degradation and ubiquitin-mediated proteolysis, providing valuable insights into cellular regulation and therapeutic interventions.
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CRBN ligand-274 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling targeted protein degradation through the recruitment of CRBN to specific substrate proteins. It serves as a critical component in the design of PROTAC (proteolysis-targeting chimera) molecules, facilitating the ubiquitination and subsequent degradation of the target protein. This reagent is valuable for researchers investigating protein regulation and developing therapeutic strategies in oncology and other disease areas.
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CRBN ligand-417 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN, enabling targeted protein degradation through the PROTAC (Proteolysis Targeting Chimeras) approach. This compound is valuable in studying protein regulation and degradation mechanisms, making it a useful tool in cancer research and drug discovery applications.
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CRBN ligand-608 is a highly selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of the CRBN protein. This compound can be effectively used in the synthesis of PROTACs (Proteolysis Targeting Chimeras) by linking it to target protein ligands through a suitable linker. Its application in protein degradation research provides a valuable tool for studying disease mechanisms and therapeutic interventions.
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CRBN ligand-609 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker, enabling the development of Proteolysis Targeting Chimeras (PROTACs). CRBN ligand-609 is valuable for research applications in the study of targeted therapeutics and protein homeostasis.
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Thalidomide-pinacolborane is a Thalidomide analogue that incorporates a boronic pinacol ester (Bpin group) and serves as an activator for E3 ligases. This compound plays a crucial role in ubiquitination, facilitating the targeted degradation of proteins through proteolytic pathways. Its applications in chemical biology include studies on protein regulation and modulation of cellular signaling processes, making it a valuable tool in research focused on proteostasis and therapeutic interventions.
CRBN ligand-262 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It serves as a crucial component in the development of Proteolysis Targeting Chimeras (PROTACs) when conjugated to target protein ligands through a linker. This compound is valuable for research applications focused on targeted protein degradation and modulation of cellular protein levels.
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CRBN ligand-596 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-596 is valuable for research applications focused on targeted protein degradation and the study of ubiquitin-mediated processes.
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CRBN ligand-722 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound is designed for use in PROTAC (Proteolysis Targeting Chimeras) applications, enabling the effective degradation of target proteins through ubiquitin-proteasome pathways. Its versatility makes it a valuable tool for studying protein turnover and targeted protein modulation in various biological contexts.
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CRBN ligand-711 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-711 is valuable in research applications focusing on targeted protein degradation and therapeutic strategies involving the modulation of cellular protein levels.
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CRBN ligand-525 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to target protein ligands through a suitable linker, enabling the formation of Proteolysis Targeting Chimeras (PROTACs). CRBN ligand-525 is instrumental in studies focused on targeted protein degradation and the modulation of cellular pathways.
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CRBN ligand-263 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it with a target protein ligand through a suitable linker, thereby enabling targeted degradation of specific proteins. It serves as a valuable tool in biochemistry and cell biology research for studies focused on proteolysis and protein regulation.
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CRBN ligand-288 is an E3 ubiquitin ligase ligand that selectively binds to cereblon (CRBN). This compound effectively recruits the CRBN protein, facilitating targeted protein degradation. It can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC for use in research applications focused on the modulation of protein levels and therapeutic intervention in various disease contexts.
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CRBN ligand-503 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimeras). CRBN ligand-503 is valuable in research focused on targeted protein degradation, providing insights into ubiquitin-proteasome pathway modulation and therapeutic strategies.
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CRBN ligand-302 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation through the recruitment of CRBN. This compound can be conjugated to a target protein ligand via a linker to form a PROTAC, enabling selective degradation of specific proteins. Its applications extend to studies in drug discovery, cancer research, and functional proteomics.
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CRBN ligand-251 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound serves as a crucial component for the development of PROTACs (proteolysis-targeting chimeras) by linking to target protein ligands through a suitable linker. Its application in chemical biology enables the modulation of protein degradation pathways, providing a valuable tool for studying protein function and therapeutic intervention in various diseases.
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CRBN ligand-368 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), essential for targeted protein degradation. It facilitates the recruitment of the cereblon protein, enabling the construction of PROTACs (proteolysis-targeting chimeras) by linking to a target protein ligand. This compound is valuable for research in ubiquitin-proteasome system studies and in the development of therapeutic strategies leveraging targeted protein degradation.
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CRBN ligand-531 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by connecting it to a target protein ligand through a suitable linker. Its application in drug discovery and development makes it a valuable tool for studying protein regulation and degradation pathways.
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CRBN ligand-887 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be linked to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It serves as a valuable tool in chemical biology for the selective degradation of target proteins, contributing to research in targeted protein regulation and degradation pathways.
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Hydrouracil-(4-Chlorophenoxy)-O-C-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is instrumental in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker. Its utility in research applications includes studies on targeted protein degradation and modulation of cellular pathways via ubiquitin-proteasome system engagement.
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CRBN ligand-414 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein in targeted protein degradation applications. By linking CRBN ligand-414 to a target protein ligand through a suitable linker, it can be utilized to construct PROTAC molecules for the specific degradation of desired proteins. This compound is instrumental in the study of ubiquitin-proteasome pathways and has significant implications in therapeutic research and drug discovery.
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CRBN ligand-719 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. This compound can be conjugated to target protein ligands through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). It is a valuable tool for researchers investigating protein regulation and degradation pathways in cellular biology.
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CRBN ligand-553 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be utilized to conjugate with target protein ligands via a linker to create Proteolysis Targeting Chimeras (PROTACs). This compound is crucial for studying targeted protein degradation and has applications in drug development and cellular biology research.
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