TRP Channel

Cat. No.

A66205

CAS No.

372-97-4

Farnesyl pyrophosphate

Synonyms: Farnesyl diphosphate

Farnesyl pyrophosphate is an agonist of the TRPM2 channel, initiating calcium influx and promoting cell death. As a vital intermediate in the mevalonate pathway, it plays a crucial role in cholesterol and ubiquinone synthesis, as well as protein farnesylation and geranylgeranyl pyrophosphate synthesis. Farnesyl pyrophosphate is utilized in research focused on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, and the study of inflammation and autoimmune disorders.

Cat. No.

A68687

CAS No.

2418670-70-7

ML-SA5

ML-SA5 is a potent agonist of the TRPML1 cation channel, effectively activating the endosomal TRPML1 current in DMD myocytes with an EC50 of 285 nM. This compound demonstrates significant anticancer activity by inhibiting tumor growth, making it valuable for research applications aimed at exploring TRPML1 functions and their implications in cancer biology and muscle disorders.

Cat. No.

A68688

CAS No.

930800-38-7

IA-Alkyne

Synonyms: Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide

IA-Alkyne is a TRPC channel (TRPC) agonist that facilitates the investigation of respiratory infections through enhanced channel activity. This compound serves as a versatile chemical probe for quantitative profiling of cysteine reactivity, enabling isotopic tagging. Additionally, IA-Alkyne features an alkyne functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool for click chemistry applications in various biological research studies.

Cat. No.

A68689

CAS No.

1031496-06-6

CIM0216

CIM0216 is a selective agonist of the TRPM3 ion channel, demonstrating potent stimulation specifically for this target over other TRPM family members such as TRPM1, TRPM2, and TRPM4-8. It activates TRPM3-dependent pathways to induce pain and facilitate the release of neuropeptides from sensory nerve terminals in vitro. This compound serves as an important research tool for investigating the physiological roles of TRPM3 and has applications in the study of neurogenic inflammation.

Cat. No.

A68696

CAS No.

924377-85-5

GSK1702934A

GSK1702934A is a selective agonist of the TRPC3 ion channel. It enhances cardiac contractility and plays a role in the modulation of arrhythmogenesis through TRPC3 activation. This compound is valuable for research applications investigating cardiac function and the physiological effects of TRPC3 modulation in various disease models.

Cat. No.

A68697

CAS No.

83883-10-7

Hydroxy-α-sanshool

Hydroxy-α-sanshool is an agonist of the transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) channels, exhibiting EC50 values of 69 μM and 1.1 μM, respectively. This compound plays a significant role in pain research by activating these nociceptive pathways, potentially contributing to studies on pain sensation and modulation.

Cat. No.

A68701

CAS No.

1062271-24-2

MK6-83

MK6-83 is a potent agonist of TRPML1, exhibiting enhanced efficacy and activity. This compound exhibits potential for research into Mucolipidosis type IV, facilitating investigations into the physiological role of TRPML1 and its implications in related pathologies. Its use may contribute to a deeper understanding of lysosomal function and associated disorders.

Cat. No.

A68708

CAS No.

1190217-35-6

ASP7663

ASP7663 is a potent and selective agonist of the transient receptor potential ankyrin 1 (TRPA1) channel. Its pharmacological profile indicates significant biological activity in alleviating constipation and reducing abdominal pain. ASP7663 serves as a valuable tool for research into gastrointestinal disorders and the modulation of nociceptive pathways.

Cat. No.

A68709

CAS No.

73255-40-0

Moringin

Moringin is a potent and selective natural agonist of the TRPA1 ion channel, exhibiting an EC50 value of 3.14 μM. It demonstrates minimal activation of vanilloid channels TRPV1, TRPV2, TRPV3, and TRPV4, as well as the cooling receptor TRPM8. Moringin is associated with various biological activities, including hypoglycemic, antimicrobial, anti-inflammatory, anticancer, and neuroprotective effects, making it valuable for research applications in these areas.

Cat. No.

A68713

CAS No.

58493-49-5

Olvanil

Synonyms: NE-19550; N-Vanillyloleamide

Olvanil (NE-19550) is a potent agonist of the transient receptor potential vanilloid type 1 (TRPV1) receptor, exhibiting an EC50 of 0.7 nM. This compound demonstrates analgesic properties and is valuable for investigating pain pathways and inflammatory responses. It is suitable for research applications focused on nociception and related signaling mechanisms.

Cat. No.

A68720

CAS No.

1008763-54-9

D-3263 hydrochloride

D-3263 hydrochloride is a selective agonist of the transient receptor potential melastatin member 8 (TRPM8) channel. This compound exhibits key biological activity by modulating nociceptive signaling pathways, which are involved in pain perception and temperature regulation. It is primarily utilized in research related to pain management, sensory neuronal activity, and the physiological responses to cold stimuli.

Cat. No.

A68722

CAS No.

2314467-59-7

TRPV4 agonist-1 free base

TRPV4 agonist-1 free base is a selective agonist of the transient receptor potential vanilloid 4 (TRPV4) channel, demonstrating an EC50 of 60 nM in human TRPV4 calcium assays. This compound induces calcium influx and is instrumental in studies focused on the physiological roles of TRPV4 in nociception, osmoregulation, and cellular mechanotransduction. Research applications include investigating the channel's involvement in pain pathways and potential therapeutic targets for related disorders.

Cat. No.

A68725

CAS No.

5947-49-9

Podocarpic acid

Podocarpic acid is a natural compound that serves as a TRP channel agonist, specifically activating the TRPA1 channel. This compound demonstrates significant biological activity in modulating sensory nerve pathways and has potential applications in pain research and neurobiology. Its unique pharmacological profile makes it a valuable tool for investigating TRP channel function and related therapeutic targets.

Cat. No.

A68728

CAS No.

3118-34-1

Hyp9

Hyp9 is a potent agonist specific for the transient receptor potential canonical 6 (TRPC6) channel. This compound facilitates TRPC6 activation, making it a valuable tool for investigating its role in cellular signaling pathways and the pathophysiology of spinal cord injury (SCI). Researchers can utilize Hyp9 to explore therapeutic strategies targeting TRPC6 in models of neuroprotection and regeneration.

Cat. No.

A68732

CAS No.

1933528-96-1

MDR-652

MDR-652 is a targeted agonist of the transient receptor potential vanilloid 1 (TRPV1) channel. This compound displays high specificity with binding affinities (Kis) of 11.4 nM for human TRPV1 and 23.8 nM for rat TRPV1. The effective concentrations (EC50s) are 5.05 nM and 93 nM for hTRPV1 and rTRPV1, respectively. MDR-652 demonstrates significant potential as a topical analgesic, making it a valuable tool in pain research and therapeutic applications.

Cat. No.

A68739

CAS No.

205687-01-0

Capsiate

Capsiate is a TRPV1 agonist derived from a non-pungent variety of CH-19 sweet red pepper. This compound exhibits potent biological activity by activating the transient receptor potential vanilloid 1 (TRPV1) channel, which is involved in the modulation of pain and inflammation pathways. Capsiate is utilized in research applications focused on pain management, metabolic studies, and the exploration of sensory receptor functions.

Cat. No.

A68742

CAS No.

103560-62-9

(E)-4-Oxo-2-nonenal

Synonyms: 4-ONE

(E)-4-Oxo-2-nonenal is a potent agonist of the transient receptor potential ankyrin 1 (TRPA1) channel, identified as a significant product of lipid hydroperoxide decomposition. This compound plays a crucial role in mediating oxidative stress responses and has been implicated in various pathological conditions. It is useful in research applications exploring TRPA1-related signaling pathways and the impact of oxidative stress on cellular functions.

Cat. No.

A68745

CAS No.

1507344-37-7

Cryosim-3

Cryosim-3 is a selective agonist of the TRPM8 receptor, known for its role in thermosensation and chemosensation. This compound enhances tear secretion and alleviates ocular discomfort in various animal models, making it valuable for research in ocular therapeutics and sensory biology. Its application may extend to understanding the modulation of pain and inflammation through TRP channel pathways.

Cat. No.

A68754

CAS No.

1562-93-2

4-(Phenyldiazenyl)benzoic acid

4-(Phenyldiazenyl)benzoic acid is a selective TRP channel agonist that exhibits photosensitivity and photochemical switchability. This compound serves as a valuable pharmacological tool in the investigation of pain signaling pathways, offering researchers the ability to modulate TRPA1 activity through light exposure. Its unique properties make it suitable for studies focusing on nociception and sensory signaling mechanisms.

Cat. No.

A68757

CAS No.

1820968-63-5

MSP-3

MSP-3 is a potent agonist of the TRPV1 receptor, characterized by an EC50 of 0.87 μM. This compound demonstrates significant neuroprotective and antinociceptive properties, making it valuable for research focused on pain modulation and neuroprotection. Its ability to activate TRPV1 makes MSP-3 an important tool for investigating sensory physiology and related therapeutic interventions.

Cat. No.

A68764

CAS No.

1374760-95-8

FEMA 4809

FEMA 4809 is a potent agonist of the TRPM8 receptor, with an EC50 of 0.2 nM. This compound is known for its ability to induce a cooling sensation through the activation of the TRPM8 ion channel, which is crucial for thermosensation. It is primarily utilized in research exploring thermal perception and related sensory pathways.

Cat. No.

A68772

CAS No.

1931116-86-7

Vocacapsaicin

Synonyms: CA-008

Vocacapsaicin is a first-in-class proagent of Capsaicin that targets the TRPV1 receptor as an agonist. This compound is known for its significant and enduring analgesic properties, making it a valuable tool in pain research. It is applicable in studies exploring non-opioid pain relief mechanisms and the modulation of sensory pathways.

Cat. No.

A68773

CAS No.

205687-03-2

Dihydrocapsiate

Dihydrocapsiate is an orally active TRPV1 agonist derived from the capsinoid family. This compound stimulates the TRPV1 receptor, playing a significant role in thermogenesis and energy metabolism. Dihydrocapsiate is valuable for research applications related to metabolic diseases, providing insights into obesity, energy expenditure, and related disorders.

Cat. No.

A68774

CAS No.

1931116-92-5

Vocacapsaicin hydrochloride

Synonyms: CA-008 hydrochloride

Vocacapsaicin hydrochloride is a potent TRPV1 agonist and a proagent of Capsaicin. This compound is primarily utilized in pain research, demonstrating significant and prolonged analgesic effects. Its unique mechanism offers valuable insights into non-opioid pain relief pathways, making it an important reagent for studies focused on pain modulation and sensory signaling.

Cat. No.

A68775

CAS No.

3083086-77-2

TRPA1 agonist-3

TRPA1 Agonist-3 is a selective agonist for the TRPA1 ion channel, displaying EC50 values of 50.05 μM for human TRPA1 and 314.04 μM for mouse TRPA1. This compound does not activate other transient receptor potential channels, including hTRPV1 and hTRPM8. TRPA1 Agonist-3 has demonstrated efficacy in alleviating inflammatory pain in mouse models, operating through a channel desensitization mechanism, making it a valuable tool for studying pain pathways and TRPA1-related pharmacology.