TRP Channel

Cat. No.

A68780

CAS No.

2415272-11-4

OptoBI-1

OptoBI-1 is a photochromic agonist of the TRPC3 channel, functioning as a photopharmacological agent to modulate neuronal activity. This compound enables precise control of neuronal firing through light-induced conformational changes, facilitating studies in neural circuitry and synaptic transmission. OptoBI-1 is valuable for researchers investigating the role of TRPC3 in neurophysiology and related biological processes.

Cat. No.

A68782

CAS No.

57086-93-8

N-Linolenoylethanolamine

Synonyms: 18:3 NAE; α-Linolenoyl ethanolamide

N-Linolenoylethanolamine (18:3 NAE) is a TRPV1 agonist that functions as an endocannabinoid. This compound is known to modulate pain and inflammatory responses through its interaction with the transient receptor potential vanilloid 1. It is valuable in research applications focused on neurobiology, pain management, and the endocannabinoid system.

Cat. No.

A68787

CAS No.

2314467-60-0

TRPV4 agonist-1

TRPV4 agonist-1 is a selective agonist of the transient receptor potential vanilloid 4 (TRPV4) channel, exhibiting an EC50 of 60 nM in human TRPV4 calcium assays. This compound is primarily utilized in research to investigate TRPV4-mediated pathways, including physiological functions like osmosensation and nociception. Its ability to activate TRPV4 makes it valuable for studying various biological processes and potential therapeutic applications related to TRP channels.

Cat. No.

A68791

CAS No.

70342-29-9

Methyl kakuol

Methyl kakuol is a selective agonist of the transient receptor potential ankyrin 1 (TRPA1) channel, exhibiting an effective concentration (EC50) of 0.27 µM. This compound facilitates the activation of TRPA1, making it a valuable tool for research into sensory pathways and pain mechanisms. Its ability to modulate TRPA1 activity can aid in the exploration of neurophysiological responses and the development of therapeutic strategies targeting pain and inflammation.

Cat. No.

A68792

CAS No.

1810726-08-9

Polygodial pyridazine

Polygodial pyridazine is a TRPV1 agonist that exhibits a GI50 of 72 μM against MCF-7 cancer cell lines. This compound is a polygodial analogue that plays a crucial role in exploring the mechanisms of pain perception and inflammation. It is applicable for research focused on cancer biology and the modulation of sensory neuronal pathways.

Cat. No.

A68797

CAS No.

2791281-99-5

TRPM8 receptor agonist-1

TRPM8 receptor agonist-1 is a selective agonist for the TRPM8 receptor, known for its ability to induce the inward flow of calcium, sodium, and other ions, resulting in cell membrane depolarization and subsequent action potential generation. This compound plays a crucial role in activating pathways associated with the swallowing reflex, making it valuable for research on oropharyngeal dysphagia and related conditions. Its activation of TRPM8 receptors positions it as a significant tool for exploring ion channel dynamics and therapeutic approaches in dysphagic disorders.

Cat. No.

A68804

CAS No.

946572-73-2

Capsiconiate

Synonyms: Coniferyl (E)-8-methyl-6-nonenoate

Capsiconiate, a TRPV1 agonist, exhibits a potent efficacy with an EC50 of 3.2 μM. This compound serves as a valuable tool for investigating TRPV1-mediated conditions, including pain, inflammation, and epilepsy. Its ability to activate the TRPV1 receptor makes it significant in the study of related pathophysiological mechanisms and therapeutic interventions.

Cat. No.

A68808

CAS No.

71291-80-0

TRPA1 Antagonist 3

TRPA1 Antagonist 3 is a photoswitchable TRPA1 agonist designed to facilitate optical control of the TRPA1 channel. This compound allows for precise modulation of TRPA1 activity, making it an essential tool for research in sensory physiology and nociception. Its unique properties enable researchers to investigate the roles of TRPA1 in pain pathways and other physiological processes with enhanced spatial and temporal resolution.

Cat. No.

A68833

CAS No.

1589567-51-0

TRPC3 agonist-1

TRPC3 agonist-1 is a selective and competitive agonist of the TRPC3 channel, acting primarily at the L2 binding site of human TRPC3. This compound enhances TRPC3 channel activity, making it valuable for research on calcium signaling pathways and related physiological processes. Its ability to modulate TRPC3 function can aid in investigations of various conditions, including neurological disorders and cardiovascular diseases.

Cat. No.

A68835

CAS No.

379262-36-9

SA-13353

SA-13353 is a potent agonist of the TRPV1 receptor, known for its cardioprotective effects. This compound is instrumental in the study of cardiovascular diseases, facilitating research into mechanisms of cardiac protection and potential therapeutic interventions. Its ability to modulate TRPV1 activity makes it a valuable tool for investigating the role of this receptor in cardiovascular health.

Cat. No.

A68839

CAS No.

2763372-26-3

TRPV1 agonist-1

TRPV1 agonist-1 is a potent agonist of the transient receptor potential vanilloid 1 (TRPV1) channel, exhibiting EC50 values of 4.5 nM and 0.57 nM for human and rat TRPV1, respectively. This compound is effective in enhancing swallowing function in preclinical rat models, making it valuable for investigating dysphagia and related disorders. Its non-irritating profile allows for potential applications in functional studies involving TRPV1 modulation.

Cat. No.

A68840

CAS No.

289902-71-2

JYL-273 analog-1

JYL-273 analog-1 is a potent agonist of the transient receptor potential vanilloid 1 (TRPV1) ion channel, exhibiting a Ki value of 10.8 nM. This compound demonstrates significant analgesic activity, with an ED50 of 1.0 mg/kg in the PBQ-induced writhing test. JYL-273 analog-1 is suitable for investigations into pain mechanisms and the development of analgesic therapies.

Cat. No.

A68843

CAS No.

2768029-03-2

TRPM5 agonist-1

TRPM5 agonist-1 is a potent TRPM5 agonist with a pEC50 of 8.1, demonstrating strong selectivity over related cation channels such as TRPM8, TRPV1, TRPV4, TRPA1, and TRPM4. This compound elicits a stimulatory effect on gastrointestinal transit in mouse models, making it valuable for studies focused on enhancing gastric motility. TRPM5 agonist-1 is suitable for research exploring the roles of TRPM5 in gastrointestinal physiology and motility regulation.

Cat. No.

A68851

CAS No.

13058-04-3

(E/Z)-Farnesyl pyrophosphate

Synonyms: (E/Z)-Farnesyl diphosphate

(E/Z)-Farnesyl pyrophosphate is a 15-carbon isoprenoid that acts as a TRPM2 agonist, facilitating ion influx through the channel. As a critical metabolic intermediate of the mevalonate pathway, it plays a significant role in cholesterol synthesis, ubiquinones synthesis, and protein farnesylation. This compound is essential for research in cellular signaling and lipid metabolism, providing insights into various biological processes and potential therapeutic targets.

Cat. No.

A68853

CAS No.

113168-57-3

Linopirdine dihydrochloride

Synonyms: DuP 996 dihydrochloride

Linopirdine dihydrochloride is an agonist of the capsaicin receptor TRPV1, which plays a key role in nociception. This compound enhances intracellular calcium levels in HEK293 cells, leading to increased excitatory responses in mammalian nociceptors. Linopirdine dihydrochloride is valuable for research applications focused on pain mechanisms and sensory neuron function.

Cat. No.

A68854

CAS No.

1391826-17-7

JYL-273

JYL-273 is a potent TRPV1 agonist, exhibiting an IC50 of 361 nM in CHO-TRPV1 cell lines. This compound is useful for studying pain mechanisms and sensory neuron activation, making it a valuable tool in pain research and neurobiology. Its ability to selectively activate TRPV1 can aid in the investigation of pain pathways and the development of analgesic therapies.

Cat. No.

A68871

CAS No.

111864-49-4

2′-Deoxy-ADPR

2′-Deoxy-ADPR is an agonist of the transient receptor potential melastatin 2 (TRPM2) channel. This compound is involved in calcium signaling within cells, particularly in Jurkat T-lymphocytes, where it plays a critical role in mediating cellular responses. 2′-Deoxy-ADPR is valuable for research investigating the effects of TRPM2 activation in various physiological and pathological processes.

Cat. No.

A68875

CAS No.

289902-82-5

MSK-195

MSK-195 is a potent agonist of the transient receptor potential vanilloid 1 (TRPV1) channel, demonstrating a potency of 120 nM and an efficacy of 71% in inducing arteriolar responses. This compound is valuable for research applications aimed at understanding pain pathways, neurogenic inflammation, and the physiological role of TRPV1 in various tissues. Its ability to selectively activate TRPV1 makes it a useful tool for dissecting the functions and mechanisms associated with this receptor in preclinical studies.

Cat. No.

A68878

CAS No.

289902-64-3

JYL-79

JYL-79 is a potent TRPV1 agonist, exhibiting an IC50 of 3.9 nM. It is primarily used in research focused on neuropathic pain, allowing for the exploration of TRPV1's role in pain pathways and potential therapeutic interventions. This compound provides valuable insights into the mechanisms of pain modulation and serves as a tool for investigating the biology of sensory neurons.

Cat. No.

A73397

CAS No.

184003-14-3

SU200

SU200 is a TRPV1 agonist that modulates intracellular calcium ion concentrations. It induces distinct calcium ion response patterns, displaying notable reactivity and peak efficacy. The effects of SU200 exhibit varying degrees of response delay and variability across different cell types. This compound offers potential avenues for pharmacological development and further research into calcium signaling pathways.

Cat. No.

A96731

CAS No.

69173-71-3

17-Hydroxy Capsaicin

17-Hydroxy Capsaicin is a natural product derived from chili peppers, exhibiting significant activity as a vanilloid receptor (TRPV1) agonist. This compound is known to modulate pain perception and has demonstrated anti-inflammatory properties. Its applications in research include exploring mechanisms of pain relief and the development of novel analgesics, making it a valuable tool in pharmacological studies.