Caspase

Cat. No.

A12373

CAS No.

187389-52-2

Z-VAD-FMK

Synonyms: Z-VAD(OMe)-FMK

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Cat. No.

A10984

CAS No.

273404-37-8

Belnacasan (VX-765)

Synonyms: VX765

VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.

Cat. No.

A13503

CAS No.

210344-95-9

Z-DEVD-FMK

Synonyms: Caspase-3 Inhibitor

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.

Cat. No.

A14915

CAS No.

1135695-98-5

Q-VD-OPh

Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).

Cat. No.

A13652

CAS No.

297730-17-7

AVN-944

Synonyms: VX-944

AVN-944 (also known as VX-944) serves as an effective oral inhibitor, specifically targeting and inhibiting IMPDH (inosine monophosphate dehydrogenase). This enzyme plays a crucial role as a rate-limiting factor in the synthesis of guanine nucleotides from scratch. Additionally, AVN-944 acts against the synthesis of RNA in arenaviruses, effectively preventing arenavirus infections. Demonstrating a wide spectrum of anti-cancer properties, AVN-944 is utilized in research related to multiple myeloma (MM) and acute myeloid leukemia (AML).

Cat. No.

A12800

CAS No.

210344-98-2

Z-IETD-FMK

Synonyms: Benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone; Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK

Z-IETD-FMK is a specific inhibitor of caspase 8.

Cat. No.

A14358

CAS No.

210345-04-3

Z-LEHD-FMK

Synonyms: Caspase-9 Inhibitor; Z-LEHD-fluoromethylketone

Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity.

Cat. No.

A16317

CAS No.

210344-97-1

Z-YVAD-FMK

Synonyms: Caspase-1 inhibitor VI

Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.

Cat. No.

A12697

CAS No.

767287-99-0

Z-DQMD-FMK

Synonyms: Z-D(OMe)QMD(OMe)-fmk

Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3.

Cat. No.

A14100

CAS No.

908253-63-4

Nivocasan (GS-9450)

Synonyms: GS 9450; LB 84451 GS 9450; LB 84451

Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.

Cat. No.

A15300

CAS No.

745046-84-8

Ivachtin

Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).

Cat. No.

A11212

CAS No.

223568-55-6

EP1013

Synonyms: F1013

EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.

Cat. No.

A11356

CAS No.

634911-80-1

BOC-D-FMK

Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.

Cat. No.

A11394

CAS No.

254750-02-2

Emricasan

Synonyms: IDN-6556; PF 03491390

Emricasan is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases.

Cat. No.

A12267

CAS No.

92953-10-1

Clofilium tosylate

Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent.

Cat. No.

A12611

CAS No.

210344-96-0

Z-VEID-FMK

Synonyms: Caspase-6 inhibitor (fluoromethylketone); Benzyloxycarbonyl-Val-Glu(OMe)-Ile-Asp(OMe)-fluoromethylketone

Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2. Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability.

Cat. No.

A12637

CAS No.

210344-92-6

Z-VDVAD-FMK

Synonyms: Z-VDVAD-fluoromethylketone; Caspase-2 Inhibitor (fluoromethylketone); Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK

Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes.

Cat. No.

A14284

CAS No.

197855-65-5

Z-FA-FMK

Z-FA-FMK is an irreversible cysteine protease inhibitor.

Cat. No.

A14916

CAS No.

210345-00-9

Z-WEHD-FMK

Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity.

Cat. No.

A14919

CAS No.

220509-74-0

MMPSI

MMPSI is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).

Cat. No.

A15291

CAS No.

210345-03-2

Ac-LEHD-AFC

Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.

Cat. No.

A15294

CAS No.

331645-84-2

AZ 10417808

AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM).

Cat. No.

A15319

CAS No.

1135417-31-0

Ac-IEPD-AFC

Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.

Cat. No.

A15392

CAS No.

187389-53-3

Boc-Asp(OMe)-FMK

Synonyms: Boc-Asp(OMe)-fluoromethyl ketone

Boc-Asp(OMe)-FMK is a Novel inhibitor of Caspase-3.  

Cat. No.

A15816

CAS No.

169332-60-9

Ac-DEVD-CHO

Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor.