TNF-α

Cat. No.

A11974

CAS No.

6823-69-4

GW 4869

GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).

Cat. No.

A11973

CAS No.

4311-88-0

Necrostatin-1

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).

Cat. No.

A12748

CAS No.

545380-34-5

QNZ (EVP4593)

Synonyms: CAY10470; EVP4593

QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling.

Cat. No.

A10743

CAS No.

19171-19-8

Pomalidomide (CC-4047)

Synonyms: Actimid; CC-4047

Pomalidomide is a derivative of thalidomide and acts as an immunomodulator.

Cat. No.

A10924

CAS No.

50-35-1

Thalidomide

Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.

Cat. No.

A12009

CAS No.

185243-69-0

Etanercept

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor.

Cat. No.

A12197

CAS No.

1021497-97-1

KR-33493

KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).

Cat. No.

A12313

CAS No.

332420-90-3

C 87

C87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.

Cat. No.

A15183

CAS No.

852391-19-6

Necrostatin 2

Synonyms: MTH-DL-Tryptophan; Necroptotic Inhibitor

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

Cat. No.

A15327

CAS No.

852391-15-2

Necrostatin 2 racemate

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

Cat. No.

A15328

CAS No.

852391-20-9

Necrostatin 2 S enantiomer

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

Cat. No.

A15688

CAS No.

541-91-3

Muscone

Synonyms: Methylexaltone; 3-Methylcyclopentadecanone

Muscone, a TNF receptor inhibitor, is derived from the traditional Chinese medicine musk. It effectively inhibits NF-κB signaling and NLRP3 inflammasome activation, resulting in a significant reduction of inflammatory cytokines such as IL-1β, TNF-α, and IL-6. This compound is valuable in research focused on inflammation, cardiac function restoration, and improving survival rates in various pathological conditions.

Cat. No.

A17238

CAS No.

37854-59-4

Ro 08-2750

Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM).

Cat. No.

A18705

CAS No.

1358099-18-9

C25-140

C25-140, a first-in-class, fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.

Cat. No.

A18773

CAS No.

2101765-81-3

DRI-C21045

DRI-C21045 is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM.

Cat. No.

A19364

CAS No.

869998-49-2

SPD304

SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor.

Cat. No.

A19687

CAS No.

444287-49-4

TNF-α-IN-1

TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7.

Cat. No.

A22192

CAS No.

1333714-43-4

(Rac)-Benpyrine

(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research.

Cat. No.

A22416

CAS No.

1515888-53-5

UCB-9260

UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM.

Cat. No.

A22451

CAS No.

183619-38-7

CPI-1189

Synonyms: REN 1654; REN 1189

CPI-1189 (REN 1654, REN 1189) is the proapoptotic cytokine tumor necrosis factor (TNF) alpha inhibitor.

Cat. No.

A24017

CAS No.

2767422-72-8

HS-276

HS-276 is an orally bioavailable, potent, and highly selective inhibitor of transforming growth factor-β–activated kinase 1 (TAK1), with a Kᵢ of 2.5 nM. It exhibits strong inhibition of TAK1 and moderate activity against a panel of other kinases, including CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with respective IC₅₀ values ranging from 8.25 to 5585 nM. HS-276 is a valuable tool for investigating TAK1-mediated signaling pathways and holds therapeutic potential for inflammatory conditions such as rheumatoid arthritis (RA).

Cat. No.

A25073

CAS No.

1391980-92-9

Necroptosis-IN-1

Necroptosis-IN-1 is a potent inhibitor of necroptosis, primarily targeting receptor-interacting protein kinase (RIPK). This compound effectively hinders necroptotic cell death pathways, making it a valuable tool for research involving cell death mechanisms. Its application spans studies related to inflammation, neurodegeneration, and cancer, providing insights into the role of necroptosis in various pathological conditions.

Cat. No.

A25182

CAS No.

338773-13-0

TNF-α-IN-19

TNF-α-IN-19 is a selective inhibitor of TNFα, effectively disrupting the interaction between TNFα receptor 1 (TNFαRI), TNF receptor-associated death domain (TRADD), and receptor-interacting protein 1 (RIP1). It exhibits EC50 values of 2.451 μM for TNFα, 3.792 μM for IL-1β, and 1.54 μM for the TNFα/IL-1β combination. Notably, TNF-α-IN-19 specifically inhibits the degradation of IκBα induced by TNFα stimulation, while showing no effect in IL-1β stimulated conditions. This compound is valuable for research into inflammatory pathways and therapeutic interventions in TNFα-mediated diseases.

Cat. No.

A25228

CAS No.

169136-33-8

Necrostatin-21

Necrostatin-21 is a potent necroptosis inhibitor targeting receptor-interacting protein kinase 1 (RIP1) and c-Jun N-terminal kinase 3 (JNK3) with an EC50 of 0.5 μM. This compound demonstrates an ability to modulate cell death pathways, making it valuable for research into various conditions including infections, cardiovascular diseases, and neurodegenerative disorders such as Alzheimer’s disease. Its dual action on key kinases provides insight into the mechanisms underlying necroptosis and potential therapeutic approaches.

Cat. No.

A25512

CAS No.

18138-19-7

IDT

IDT is a TNFα modulator that targets and regulates the innate immune response. It has demonstrated significant efficacy in reducing paired helical filament tau and fibrillar amyloid accumulation, as well as enhancing the infiltration of neutrophils while decreasing TNFα expression within this population. IDT is a valuable reagent for research focused on Alzheimer’s disease and the underlying mechanisms of neuroinflammation.