AhR

Aryl hydrocarbon receptor (AhR) ligands act on a ligand-activated transcription factor of the bHLH-PAS family. Cloning of the receptor complementary DNA in 1992 showed that AhR combines a basic helix-loop-helix (bHLH) domain with a Per-Arnt-Sim (PAS) domain. The tryptophan metabolite kynurenine was later described as an endogenous agonist produced by tryptophan 2,3-dioxygenase. Antagonists of AhR were shown to support the expansion of human hematopoietic stem cells in culture, which made StemRegenin 1 a common tool in that work. CH-223191, ITE, tapinarof and L-Kynurenine complete a set that covers both receptor activation and blockade in reporter and gene expression assays.

3 Items

  • 10-Cl-BBQ
    Cat. No.
    A64082

    10-Cl-BBQ

    10-Cl-BBQ is a high-affinity ligand for the aryl hydrocarbon receptor (AhR), exhibiting significant immunosuppressive activity. This compound facilitates the translocation of AhR from the cytosol to the nucleus and effectively activates AhR-regulated reporter genes at nanomolar concentrations. Its properties make 10-Cl-BBQ a valuable tool for research in immunology and toxicology, particularly in studies focusing on AhR signaling pathways.

    5 mg
    $75.00
    10 mg
    $125.00
    All 5 sizes
  • Benz[a]anthracene
    Cat. No.
    A64086

    Benz[a]anthracene

    Synonyms: Tetraphene

    Benz[a]anthracene is an aromatic hydrocarbon receptor (AhR) ligand, displaying a pIC50 value of 7.319. As a polycyclic aromatic hydrocarbon (PAH), it is important for studies investigating AhR-mediated biological processes and environmental toxicity. This compound is also relevant in assessing pollution impacts, particularly in samples from areas influenced by industrial activities such as aluminum smelting.

    5 mg
    $40.00
    10 mg
    $60.00
    All 6 sizes
  • β-Naphthoflavone-CH2-Br
    Cat. No.
    A80147

    β-Naphthoflavone-CH2-Br

    Synonyms: β-NF-CH2-Br

    β-Naphthoflavone-CH2-Br is a ligand for the arylhydrocarbon receptor (AhR), involved in regulating various biological processes, including xenobiotic metabolism. This compound serves as a key intermediate for synthesizing the PROTAC β-NF-JQ1, facilitating targeted protein degradation research. Its role in modulating AhR activity makes it valuable for studies in toxicology, pharmacology, and cancer research.

    5 mg
    $205.00
    10 mg
    $380.00
    All 5 sizes

3 Items

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