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LXR

Liver X receptor (LXR) agonists and antagonists act on oxysterol-activated nuclear receptors. LXRα and LXRβ were shown in 1996 to respond to oxidized cholesterol derivatives such as 24,25-epoxycholesterol. Through sterol regulatory element-binding protein 1c (SREBP-1c) they link sterol sensing to fatty acid synthesis in liver, and they also drive genes of reverse cholesterol transport. GW3965 and GW3965 HCl are synthetic agonists of both subtypes and are widely used in such gene expression work. T0901317 activates LXR but also acts on the farnesoid X receptor, so selectivity controls matter. GSK-2033 acts as an antagonist and SR9243 as an inverse agonist, which allows loss-of-function comparisons in the same system.

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  • Dendrogenin A
    Cat. No.
    A76537
    CAS No.
    1191043-85-2

    Dendrogenin A

    Synonyms: DDA

    Dendrogenin A (DDA) is a selective ligand for the liver X receptor (LXR) that promotes the expression of the sodium/iodine symporter, leading to enhanced iodine uptake. This compound has been shown to induce cell differentiation in MCF-7 breast cancer cells and reactivate the function of lactating cells. Dendrogenin A also upregulates the expression of the thyroid-stimulating hormone receptor, thyroid peroxidase, and thyroglobulin, influencing the generation of thyroid hormones. Additionally, DDA exhibits cytotoxic effects on cancer cell lines B-CPAP and 8505c, with IC50 values of 4.1 and 6.2 µM, respectively, and it effectively arrests the cell cycle at the G0/G1 phase.

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    1 mg
    $70.00
    5 mg
    $250.00
    All 3 sizes

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