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Glycosidase

Glycosidase inhibitors, enzymes and substrates are tools for studying how glycans are broken down. Glycosidases remove sugars from glycoproteins, glycolipids and polysaccharides and shape N-glycan processing in the endoplasmic reticulum and Golgi apparatus. Kifunensine, an alkaloid, was reported in 1990 to inhibit glycoprotein processing mannosidase I, so N-glycans stay in high-mannose form. Peptide-N-glycosidase F (PNGase F) releases intact N-linked glycans from glycoproteins, as described in 1985. OGT2115 inhibits heparanase, the endo-β-glucuronidase that cleaves heparan sulfate chains. M-31850 inhibits β-hexosaminidase, and PFB-FDGlu is a fluorogenic substrate for glucocerebrosidase (GCase). Enzymes that cleave glucose residues have their own neighboring category, Glucosidase.

2 Items

  • p-Nitrophenyl α-D-mannopyranoside
    Cat. No.
    A75054
    CAS No.
    10357-27-4

    p-Nitrophenyl α-D-mannopyranoside

    Synonyms: 4-Nitrophenyl a-D-mannopyranoside

    p-Nitrophenyl α-D-mannopyranoside is a chromogenic glycosidic ligand targeting glycosidase enzymes. This compound contains an α-D-mannopyranose moiety with a distinctive axial hydroxyl group at the C2 position, along with a p-nitrophenol portion that absorbs ultraviolet-visible light. p-Nitrophenyl α-D-mannopyranoside is essential for assessing glycosidase activity and exploring the sugar recognition properties of lectins, including Concanavalin A.

    In stock View Details
    100 mg
    $30.00
    250 mg
    $50.00
    All 2 sizes
  • GT-02216
    Cat. No.
    A75057
    CAS No.
    2648407-76-3

    GT-02216

    GT-02216 is an allosteric ligand for Glucosylceramidase (GCase) that enhances its enzymatic activity. This compound not only promotes the activity of GCase in primary human fibroblasts in a dose-dependent manner but also effectively reduces the accumulation of hexosylsphingosine (HexCer), a substrate linked to various pathologies. Additionally, GT-02216 has demonstrated the ability to decrease Tau accumulation in mutant GBA1 fibroblasts, making it a valuable tool in the study of Parkinson’s disease and related neurodegenerative conditions.

    In stock View Details
    5 mg
    $450.00
    10 mg
    $735.00
    All 5 sizes

2 Items

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