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Cholesterol & Lipoprotein Metabolism

Cholesterol and lipoprotein metabolism compounds target sterol synthesis and lipoprotein handling. Cholesterol is built through the mevalonate pathway, which also yields farnesyl and geranylgeranyl pyrophosphate for protein prenylation. Lapaquistat acetate and L-731120 inhibit squalene synthase, the branch point that commits farnesyl pyrophosphate to sterol synthesis. NE 10790 acts on farnesyl pyrophosphate synthase (FPPS), while hGGPPS-IN-1 blocks human geranylgeranyl pyrophosphate synthase. Intracellular sterol transport is addressed by Y18501, an inhibitor of oxysterol-binding protein (OSBP). Pelacarsen sodium is an antisense oligonucleotide directed against apolipoprotein(a), the protein that distinguishes lipoprotein(a) from low-density lipoprotein particles.

1 Item

  • FPPS ligand 3
    Cat. No.
    A98551
    CAS No.
    51527-19-6

    FPPS ligand 3

    FPPS Ligand 3 is a potent farnesyl pyrophosphate synthase (FPPS) ligand that interacts with the hydrophobic base region of the FPPS binding pocket. This compound is instrumental in the design and synthesis of novel FPPS inhibitors, offering valuable insights for research in metabolic disorders, cancer biology, and related therapeutic areas. Its precise targeting of FPPS makes it a crucial tool for studies aiming to modulate isoprenoid biosynthesis pathways.

    In stock View Details
    100 mg
    $60.00
    250 mg
    $115.00
    All 4 sizes

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