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Angiotensin-converting Enzyme (ACE)

Angiotensin-converting enzyme (ACE) inhibitors block the peptidase that turns angiotensin I into angiotensin II. In 1956 the activity was described in plasma as a hypertensin-converting enzyme that generates the pressor peptide. ACE also inactivates bradykinin, so it connects the renin-angiotensin-aldosterone system (RAAS) with the kinin system. Molecular cloning in 1988 showed that somatic ACE carries two homologous domains, each with a putative active center. Carboxyalkanoyl and mercaptoalkanoyl amino acids, designed in 1977, set the structural pattern for most later inhibitors. Enalapril maleate, ramipril and perindopril erbumine are carboxylate-type prodrugs, whereas fosinopril sodium contains a phosphinate group and zofenopril calcium a protected thiol group.

1 Item

  • Oberadilol
    Cat. No.
    A42361
    CAS No.
    114856-44-9

    Oberadilol

    Synonyms: CID-3047798

    Oberadilol is an ACE2 receptor binding agent that interacts with the human ACE2 receptor as well as SARS-CoV proteins, including the Spike S glycoprotein and the main protease. It exhibits a binding affinity characterized by a Kd of 23.18 mM specifically for the SARS-CoV-2 main protease. This compound is valuable for research applications focused on the mechanisms of viral entry and infection, as well as potential therapeutic strategies against SARS-CoV-2.

    In stock View Details
    25 mg
    $1,905.00
    50 mg
    $2,445.00
    All 3 sizes

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