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FXR

Farnesoid X receptor (FXR) agonists and antagonists act on a nuclear receptor that senses bile acids. In 1999 three groups identified bile acids such as chenodeoxycholic acid as endogenous FXR ligands. FXR is expressed mainly in liver, intestine and kidney, where it controls bile acid synthesis, transport and enterohepatic circulation. Activated FXR induces small heterodimer partner, which represses cholesterol 7α-hydroxylase, the rate-limiting enzyme of bile acid synthesis. FXR ligands are used to study bile acid, lipid and glucose metabolism and liver fibrosis models. Steroidal agonists include obeticholic acid, a semisynthetic bile acid analog. GW4064, cilofexor and tropifexor are nonsteroidal agonists, while DY 268 serves as an FXR antagonist.

1 Item

  • sEH/FXR-IN-1
    Cat. No.
    A74586
    CAS No.
    59089-68-8

    sEH/FXR-IN-1

    sEH/FXR-IN-1 is a selective ligand for soluble epoxide hydrolase (sEH) and the farnesoid X receptor (FXR). This compound demonstrates biological activity by modulating sEH enzymatic activity and influencing FXR signaling pathways. It is utilized in research related to metabolic disorders, inflammation, and liver disease, offering potential insights into therapeutic strategies targeting these pathways.

    In stock View Details
    25 mg
    $20.00
    50 mg
    $30.00
    All 3 sizes

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