Retinoid Receptor

Cat. No.

A45007

CAS No.

198696-03-6

DC271

DC271 is a potent RAR agonist that functions as a retinoid, stimulating cellular responses similar to those of endogenous retinoic acid (ATRA) and the synthetic retinoid EC23. By binding to retinoid protein machinery such as CRABPII, DC271 facilitates the translocation of ATRA into the nucleus, enhancing retinoid signaling pathways. This compound is valuable for research applications involving gene expression regulation, differentiation, and cellular growth in various biological contexts.

Cat. No.

A53357

CAS No.

127471-94-7

MDI-403

MDI-403 is a highly potent retinoic acid receptor (RAR) agonist, exhibiting an EC50 value of less than 1 μM. It demonstrates significant antiviral activity against SARS-CoV-2 by dose-dependently inhibiting the expression of viral nucleoprotein (NP) and decreasing the proportion of infected cells, mainly during the virus invasion stage. MDI-403 serves as a valuable tool for research focused on the mechanisms of antiviral activity and potential therapies against SARS-CoV-2.

Cat. No.

A65099

CAS No.

2456434-36-7

MSU-42011

MSU-42011 is an orally active retinoid X receptor (RXR) agonist that demonstrates significant immunomodulatory and antitumor properties. This compound effectively inhibits inducible nitric oxide synthase (iNOS) activity and downregulates the expression of phosphorylated extracellular signal-regulated kinase (p-ERK) protein. MSU-42011 is a valuable tool for research applications focused on cancer biology and immunology.

Cat. No.

A77450

CAS No.

215030-90-3

BMS493

BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist that enhances nuclear corepressor interaction with RARs, effectively inhibiting retinoic acid-induced differentiation. This compound serves as a valuable tool in research applications focused on RAR signaling pathways and their regulatory mechanisms. Additionally, BMS493 features an alkyne group, enabling its use in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating diverse labeling and conjugation strategies.

Cat. No.

A77453

CAS No.

146670-40-8

SR11237

Synonyms: BMS-649

SR11237 is a potent retinoid X receptor (RXR)-selective agonist that exhibits no activity on retinoic acid receptors (RARs). This compound efficiently induces the formation of RXR/RXR homodimers and effectively transactivates reporter genes containing RXR-responsive elements. It is valuable for research in areas related to nuclear hormone signaling pathways and RXR-mediated transcriptional regulation.

Cat. No.

A77454

CAS No.

110368-33-7

Ch55

Ch55 is a potent agonist of the retinoic acid receptors RAR-α and RAR-β. It demonstrates a high affinity for these receptors while exhibiting low binding affinity for cellular retinoic acid binding protein (CRABP). Ch55 effectively induces differentiation in HL60 cells, with an EC50 of 200 nM. This compound is particularly valuable in cancer research applications, offering insights into retinoid-mediated pathways in tumorigenesis and cell differentiation.

Cat. No.

A77455

CAS No.

196961-43-0

CD3254

CD3254 is a potent and selective retinoid-X-receptor (RXR) agonist that plays a crucial role in modulating gene expression related to lipid metabolism, apoptosis, and differentiation. Its activation of RXR can influence signaling pathways involved in various diseases, making it a valuable tool for research in metabolic disorders and cancer. CD3254 is suitable for studies investigating RXR's role in cellular processes and its potential therapeutic applications.

Cat. No.

A77458

CAS No.

215307-86-1

BMS 753

BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, exhibiting a Ki of 2 nM. This compound modulates gene expression linked to cellular differentiation, proliferation, and apoptosis through RARα activation. Its selective action makes BMS 753 valuable for investigating the role of RARα in various biological processes and potential therapeutic areas, including cancer research and regenerative medicine.

Cat. No.

A77460

CAS No.

170355-37-0

CD2314

CD2314 is a potent and selective agonist of the RARβ receptor, exhibiting a Kd of 195 nM in S91 melanoma cells. This compound modulates retinoic acid signaling pathways, promoting cellular differentiation and apoptosis. CD2314 is valuable for investigating the roles of RARβ in cancer biology and other research applications related to retinoid signaling.

Cat. No.

A77463

CAS No.

369364-50-1

BMS641

Synonyms: BMS-209641

BMS641 is a selective RARβ agonist with a high affinity for the RARβ receptor (Kd of 2.5 nM), exhibiting over 100-fold selectivity compared to RARα (Kd of 225 nM) and RARγ (Kd of 223 nM). This compound is valuable in investigating the role of RARβ in various biological processes and may have implications in cancer research and differentiation studies. Its specificity makes BMS641 a useful tool for elucidating RARβ-mediated signaling pathways.

Cat. No.

A77464

CAS No.

1952276-71-9

KCL-286

Synonyms: C286

KCL-286 is a potent retinoic acid receptor (RAR) β2 agonist, with an EC50 of 1.9 nM, demonstrating high selectivity over RAR α and RAR γ (EC50 = 26 nM and 11 nM, respectively). This compound activates RARβ2 specifically in injured neurons, promoting axonal regeneration in the spinal cord and sensory nerves by altering the inhibitory environment in the central nervous system. KCL-286 also modulates neuroinflammation and extracellular matrix components, influencing the expression of chondroitin sulfate proteoglycans through neuronal secretion of decorin to facilitate myelination and enhance axonal growth. It is relevant for research applications in spinal cord injury and traumatic nerve injury studies.

Cat. No.

A77465

CAS No.

870773-76-5

AC-261066

AC-261066 is a selective agonist of the retinoic acid receptor beta2 (RARbeta2) with high potency and oral bioavailability, exhibiting a pEC50 of 8.0. This compound is utilized in research to investigate the biological functions of RARbeta2 and its implications in cellular differentiation, growth, and apoptosis. Its isoform-selective action makes it a valuable tool for studies aimed at understanding retinoid signaling pathways and their therapeutic potential.

Cat. No.

A77466

CAS No.

172705-89-4

HX600

HX600 is a synthetic agonist targeting the retinoid X receptor (RXR) heterodimer complex. It demonstrates neuroprotective properties by preventing ischemia-induced neuronal damage, making it valuable for research into neurodegenerative disorders and ischemic injury. Additionally, HX600 exhibits oral bioavailability, enhancing its potential for in vivo studies.

Cat. No.

A77468

CAS No.

185629-22-5

BMS961

BMS961 is a selective agonist of the retinoic acid receptor-γ (RARγ). It demonstrates potent anti-inflammatory activity, making it a valuable tool for research into inflammatory diseases and related pathways. This compound can be utilized in studies aimed at understanding RARγ-mediated signaling and its implications in therapeutic contexts.

Cat. No.

A77474

CAS No.

856683-59-5

IRX5010

Synonyms: IRX4647F

IRX5010 is a selective agonist of the RARγ nuclear receptor. It has been shown to inhibit the in vivo growth of EMT-6 triple-negative breast cancer cells, making it a valuable tool for cancer research. This compound is particularly useful for studying the role of RARγ in tumor biology and exploring therapeutic strategies targeting this receptor.

Cat. No.

A77475

CAS No.

71441-09-3

Arotinoid

Synonyms: Ro 13-6298; Arotinoid ethyl ester

Arotinoid functions as a highly potent agonist of retinoic acid receptors (RARs). Known for its antipsoriatic effects, Arotinoid exhibits antipapilloma activity with an ED50 of 0.05 mg/kg. This compound is valuable in research related to skin carcinomas, contributing to the understanding of retinoid biology and potential therapeutic applications.

Cat. No.

A77476

CAS No.

1190848-23-7

Fluorobexarotene

Fluorobexarotene is a potent agonist of retinoid-X-receptors (RXR), exhibiting a Ki value of 12 nM and an EC50 value of 43 nM for the RXRα receptor. This compound demonstrates a binding affinity for RXR that is 75% greater than that of Bexarotene. Fluorobexarotene is valuable for research applications targeting RXR-mediated signaling pathways, which are implicated in various biological processes including cellular differentiation and metabolism.

Cat. No.

A77478

CAS No.

176390-68-4

16α-Hydroxytrametenolic acid

16α-Hydroxytrametenolic acid is a natural triterpene that selectively functions as an agonist for the retinoid X receptor (RXR). This compound has demonstrated potential in modulating RXR activity, thereby influencing pathways involved in lipid metabolism, cell differentiation, and apoptosis. Its applications in research include studying RXR's role in cancer biology and metabolic disorders, providing valuable insights into therapeutic approaches targeting these pathways.

Cat. No.

A77482

CAS No.

178600-20-9

ALRT1550

Synonyms: LGD1550

ALRT1550 is a potent selective agonist of the retinoic acid receptors (RARs), exhibiting Kd values between 1-4 nM. This compound demonstrates significant anti-proliferative effects, evidenced by an IC50 of 0.22 nM in UMSCC-22B squamous carcinoma cells. In vivo studies in mouse tumor xenograft models have shown ALRT1550 to inhibit tumor growth in a dose-dependent manner, achieving up to 89% inhibition at maximum doses. This reagent is highly relevant for research focused on cancer biology and therapeutic applications targeting the retinoic acid signaling pathway.

Cat. No.

A77484

CAS No.

1251538-60-9

NEt-iFQ

NEt-iFQ is a fluorescent retinoid X receptor (RXR) agonist that exhibits potent solvatochromic properties. This compound selectively binds to the RXR-ligand binding pocket, producing fluorescence, which facilitates studies on RXR-mediated signaling pathways. It is useful in research applications involving nuclear receptor activation and cellular imaging.

Cat. No.

A77488

CAS No.

196517-43-8

ER-38925

ER-38925 is a selective retinoid agonist targeting retinoic acid receptor subtype α (RAR-α). This compound demonstrates a dose-dependent ability to prolong the lifespan of recipient mice and effectively inhibits alloantigen-stimulated donor T lymphocyte proliferation in vitro. Additionally, ER-38925 can prevent the development of antiallogeneic cytotoxic T lymphocyte responses and suppress serum anti-DNA autoantibody production in mouse models of human chronic graft-versus-host disease (GVHD). Its unique properties make it a valuable tool for research in immunological responses and therapy development.

Cat. No.

A77490

CAS No.

13100-69-1

5,6-Epoxyretinoic acid

Synonyms: 5,6-epoxy atRA; 5,6-epoxy RA

5,6-Epoxyretinoic acid acts as an agonist for all isoforms of retinoic acid receptors (RAR), demonstrating EC50 values of 77 nM, 35 nM, and 4 nM for RARα, RARβ, and RARγ, respectively. This compound exhibits notable growth arrest in MCF-7 and NB4 cell lines at a concentration of 1 μM. As a natural metabolite of all-trans retinoic acid, which derives from vitamin A, 5,6-epoxyretinoic acid plays a significant role in various cellular processes and research applications related to cancer biology and retinoid signaling pathways.

Cat. No.

A77493

CAS No.

156691-86-0

AGN-191659

AGN-191659 is a potent agonist of retinoid X receptors (RXR) and retinoic acid receptors (RAR), exhibiting EC50 values of 11 nM, 23 nM, and 37 nM for RXRα, RARβ, and RARγ, respectively. It enhances gene transcription through activation of these receptors and has demonstrated significant biological activities, including the induction of tissue transglutaminase and suppression of chondrogenesis. Additionally, AGN-191659 effectively reverses fibroblast growth factor-induced endothelial cell proliferation and inhibits heparin-releasable lipase activity. This compound is valuable for research related to promyelocytic leukemia and hypertriglyceridemia.

Cat. No.

A77494

CAS No.

168901-49-3

BMS-948

BMS-948 is a selective agonist of the retinoic acid receptor beta (RARβ), exhibiting an EC50 of 0.1 µM. This compound plays a significant role in the modulation of gene expression related to tumor progression, embryonic development, and tissue remodeling. It serves as a valuable tool for investigating the biological functions of RARβ in various research applications.

Cat. No.

A77495

CAS No.

503620-39-1

GW0791

GW0791 is an RXRα agonist with an EC50 of 5 nM. This compound demonstrates significant biological activity in modulating retinoid signaling pathways, making it a valuable tool for cancer research. Its ability to activate RXRα offers potential insights into mechanisms of tumorigenesis and opportunities for therapeutic development.