ROR

Cat. No.

A13568

CAS No.

1359164-11-6

SR-2211

SR-2211 selectively binds RORr(Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORr activity (IC50 = 320 nM).

Cat. No.

A15245

CAS No.

1246525-60-9

SR1078

SR1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ; increases transcription of RORα target genes; thought to increase p53 stability.

Cat. No.

A16863

CAS No.

2055536-64-4

Cintirorgon (LYC-55716)

Synonyms: LYC55716

LYC-55716 is novel oral RAR-related orphan receptor γ (RORγ) agonist.

Cat. No.

A17002

CAS No.

2102196-57-4

FAA1 agonist-1

FAA1 agonist-1 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.

Cat. No.

A20422

CAS No.

303126-97-8

SR0987

SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1.

Cat. No.

A20780

CAS No.

1677668-27-7

GNE-6468

GNE-6468 is a potent and selective RORγ(RORc) agonists with an EC50 value of 13 nM for HEK-293 cell.

Cat. No.

A20782

CAS No.

1677667-24-1

GNE-0946

GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.

Cat. No.

A22536

CAS No.

1422053-04-0

TMP778

Synonyms: TMP 778.

TMP778 is a novel, potent, and selective RORγt inverse agonist.

Cat. No.

A60389

CAS No.

2276-94-0

Allolithocholic acid

Allolithocholic acid functions as a dual agonist of GPBAR1 and an inverse agonist of RORγt, exhibiting an EC50 of 2.7 μM and an IC50 of 3.4 μM, respectively. This compound modulates immune and metabolic pathways by influencing immune cell polarization and preventing the differentiation of M1 macrophages and Th17 CD4 cells. Allolithocholic acid enhances insulin sensitivity and mitigates liver lipid accumulation, while also restoring bile acid homeostasis and modulating intestinal immunity. It is a valuable reagent for research in cancer, inflammation, immunology, and metabolic disorders.

Cat. No.

A61728

CAS No.

87958-67-6

CGP52608

CGP52608 is a selective agonist for the RZR/ROR receptor, exhibiting notable anti-tumor activity with minimal interaction with the cell surface G-protein coupled melatonin receptor. This compound has been demonstrated to inhibit the proliferation of mouse 16/C breast cancer cells, making it a valuable tool in cancer research. Additionally, CGP52608 is effective in inducing vesicle formation in diatoms, providing insights into cellular mechanisms and developmental processes.

Cat. No.

A71597

CAS No.

566-97-2

Zymostenol

Synonyms: 5a-Cholest-8-en-3b-ol

Zymostenol (5a-Cholest-8-en-3b-ol) is a RORγ agonist with an EC50 of 1 μM. This compound plays a significant role as a late-stage precursor in cholesterol biosynthesis, facilitating the modulation of immune responses. Zymostenol is primarily utilized in research applications focused on investigating the mechanisms of RORγ signaling and its implications in various biological processes and diseases.

Cat. No.

A77555

CAS No.

17676-33-4

Neoruscogenin

Neoruscogenin is a high-affinity agonist of the nuclear receptor RORα (NR1F1), exhibiting an EC50 of 0.11 µM. This compound plays a crucial role in modulating gene expression and is involved in various physiological processes, including circadian rhythm and metabolism. Neoruscogenin is applicable in research areas focusing on nuclear receptor signaling and the development of therapeutics targeting metabolic disorders.

Cat. No.

A77574

CAS No.

1083-27-8

Hexyl 4-hydroxybenzoate

Synonyms: Hexylparaben

Hexyl 4-hydroxybenzoate, also known as Hexylparaben, is a selective agonist for the retinoic acid-related orphan receptor RORγ(t), exhibiting an EC50 value of 144 nM. This compound is valuable in the investigation of autoimmune diseases and immune-related processes, providing insights into the modulation of immune responses and potential therapeutic interventions. Its role in RORγ(t) signaling makes it a crucial tool for researchers studying T-cell differentiation and related pathways.

Cat. No.

A77578

CAS No.

2377378-89-5

RORγt agonist 1

RORγt agonist 1 is a potent agonist of the RORγt receptor, demonstrating an EC50 of 20.8 nM. This compound exhibits high metabolic stability, enhanced aqueous solubility, and favorable pharmacokinetics in murine models. RORγt agonist 1 is a promising candidate for cancer immunotherapy research applications, targeting immune modulation pathways to aid in therapeutic strategies.

Cat. No.

A77580

CAS No.

2260631-91-0

RORγ agonist 1

RORγ Agonist 1 is a potent agonist of the RORγ nuclear receptor, exhibiting an EC50 of 21 nM. This compound demonstrates significant antitumor activity, making it a valuable tool in cancer research. Its oral bioavailability facilitates convenient administration in preclinical studies exploring RORγ's role in tumor progression and immune modulation.

Cat. No.

A77592

CAS No.

2663787-92-4

RORγt agonist 2

RORγt Agonist 2 is a selective agonist of the Retinoic acid receptor-related orphan receptor gamma t (RORγt), which plays a critical role in the differentiation of Th17 cells. This compound enhances the production of pro-inflammatory cytokines, thereby increasing lymphocyte cytotoxicity. Additionally, RORγt Agonist 2 inhibits the generation of regulatory T cells, ultimately promoting a more robust immune response. Its applications include research in autoimmune diseases and immunotherapy.

Cat. No.

A77600

CAS No.

2425563-60-4

TF-S14

TF-S14 is a reverse agonist of RORγt, a transcription factor critically involved in Th17 cell differentiation and cytokine production. By binding to RORγt, TF-S14 effectively inhibits the secretion of pro-inflammatory cytokines such as IL-17A, IL-21, and IL-22. This compound is valuable for research applications focused on autoimmune diseases and transplantation rejection mechanisms.

Cat. No.

A77602

CAS No.

2241769-59-3

RORγt agonist 4

RORγt Agonist 4 is a potent and selective agonist of the retinoic acid receptor-related orphan receptor gamma t (RORγt). This compound enhances metabolic stability and demonstrates significant biological activity in preclinical models. Notably, RORγt Agonist 4 has shown therapeutic potential in tumor models, including mouse B16F10 melanoma and LLC lung adenocarcinoma, making it a valuable tool for investigating RORγt-mediated pathways in cancer research.

Cat. No.

A77605

CAS No.

3092129-97-7

Gala-SR

Synonyms: Gala-SR1078

Gala-SR (Gala-SR1078) is a selective RORα agonist that enhances the amplitude of circadian rhythms, making it a valuable tool for the investigation of disorders related to circadian regulation. This compound has potential applications in studying rhythm disturbances and can provide insights into the role of circadian mechanisms in periodontitis research. Its ability to modulate rhythmic activity positions it as a significant reagent in the exploration of chronobiology and its implications for human health.

Cat. No.

A77614

CAS No.

2055538-47-9

Cintirorgon sodium

Synonyms: LYC-55716 sodium

Cintirorgon sodium is a selective and orally bioavailable RORγ agonist that modulates gene expression in RORγ-expressing T lymphocytes. This compound enhances effector functions and reduces immunosuppressive mechanisms, contributing to decreased tumor growth and improved survival rates in various preclinical models. Cintirorgon sodium is a valuable tool for research applications focused on immunotherapy and cancer biology.