Vitamin D Receptors

Cat. No.

A30316

CAS No.

163217-09-2

Inecalcitol

Synonyms: TX 522

Inecalcitol is a potent vitamin D receptor (VDR) agonist with a dissociation constant (Kd) of 0.53 nM, demonstrating a strong affinity for VDR. This unique vitamin D3 analog induces apoptotic pathways and exhibits significant anticancer activities. Additionally, Inecalcitol features an alkyne group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it valuable for diverse biochemical studies and research applications.

Cat. No.

A31167

CAS No.

199798-84-0

Elocalcitol

Synonyms: BXL-628; Ro-26-9228

Elocalcitol is a selective vitamin D receptor (VDR) agonist that demonstrates oral bioactivity. It exhibits significant anti-inflammatory properties and has been shown to inhibit the growth of prostate cancer cells. This compound serves as a valuable tool for research applications focused on the modulation of VDR activity and the exploration of novel therapeutic strategies for prostate cancer and inflammatory diseases.

Cat. No.

A36096

CAS No.

233268-78-5

LG190155

LG190155 is a nonsteroidal agonist of the vitamin D receptor (VDR). It activates VDR in mesenchymal stem cells, leading to the upregulation of the BMP6-IL6 autocrine signaling axis. This enhancement significantly promotes the differentiation of acute myeloid leukemia (AML) cells from mesenchymal stem cells while avoiding hypercalcemia. LG190155 is a valuable tool for research into AML and its treatment mechanisms.

Cat. No.

A39923

CAS No.

39932-44-0

25-Hydroxytachysterol3

25-Hydroxytachysterol3 is a potent Vitamin D receptor (VDR) agonist. This metabolite of Vitamin D3 exhibits significant inhibitory effects on the proliferation of epidermal keratinocytes and dermal fibroblasts while stimulating the expression of genes associated with differentiation and antioxidant response in keratinocytes. Additionally, it activates aryl hydrocarbon receptor (AhR), liver X receptors α/β (LXR α/β), and peroxisome proliferator-activated receptor γ (PPARγ), promoting the expression of CYP24A1. These characteristics make it valuable for research in skin biology and related therapeutic applications.

Cat. No.

A69888

CAS No.

250384-82-8

Lunacalcipol

Synonyms: CTA-018

Lunacalcipol is a vitamin D receptor agonist that acts through the modulation of vitamin D signaling pathways. It demonstrates dual functionality in chronic kidney disease (CKD) by enhancing the activity of the vitamin D receptor (VDR) and inhibiting the cytochrome P450 enzyme 24-hydroxylase. By binding to VDR, Lunacalcipol influences various aspects of its transcriptional activity, including ligand affinity and coactivator recruitment. This compound is particularly relevant for research focused on CKD and secondary hyperparathyroidism (sHPT).

Cat. No.

A70217

CAS No.

71204-89-2

Calcitroic acid

Calcitroic acid is a potent vitamin D receptor (VDR) agonist that effectively activates VDR-mediated transcriptional processes. As the primary metabolite of 1,25-dihydroxyvitamin D3, it is predominantly found in the liver and mucosa of mice, exhibiting metabolic stability and minimal toxicity. This compound is valuable for research applications focusing on VDR signaling pathways and the physiological effects of vitamin D metabolites.

Cat. No.

A85529

CAS No.

32511-63-0

(1R,5Z)-Calcitriol

Synonyms: (1R,5Z)-1,25-Dihydroxyvitamin D3

(1R,5Z)-Calcitriol is an isomer of calcitriol, the most biologically active metabolite of vitamin D. This compound functions as a vitamin D receptor (VDR) agonist, influencing calcium metabolism and bone health. Its biological activity makes it valuable in research focused on bone disorders, immunomodulation, and calcium signaling pathways.

Cat. No.

A85530

CAS No.

3052323-55-1

VDR agonist 2

VDR Agonist 2 is a potent compound that acts as an agonist for the vitamin D receptor (VDR). This reagent effectively inhibits the TGF-β1-induced activation of hepatic stellate cells (HSC), demonstrating significant anti-hepatic fibrosis effects in both in vitro and in vivo studies. It is suitable for research applications focused on liver fibrosis and the mechanistic understanding of VDR-mediated pathways.

Cat. No.

A85531

CAS No.

110927-46-3

22-Hydroxyvitamin D3

22-Hydroxyvitamin D3 is a novel vitamin D analog that lacks agonist activity in both intestinal and bone tissues. Its unique profile makes it a valuable tool for research into vitamin D metabolism and signaling pathways. This compound can be utilized in studies investigating the modulation of calcium homeostasis and potential therapeutic applications in vitamin D-related disorders.

Cat. No.

A85544

CAS No.

241151-12-2

Ro-65-2299

Ro-65-2299 is an orally active vitamin D analogue that functions as a potential agonist of the vitamin D receptor (VDR), with an effective dose (ED50) of 180 nM. It promotes thickening of the epidermis and demonstrates antipsoriatic activity in hairless mice, with an ED50 of 7.5 mg/kg. This compound is suitable for research into inflammation and immunology, particularly in the context of psoriasis and related skin disorders.