CCR

Cat. No.

A10556

CAS No.

376348-65-1

Maraviroc (UK-427857)

Synonyms: Celsentri; UK-427857

Maraviroc is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection.

Cat. No.

A10971

CAS No.

541503-81-5

Vicriviroc Malate

Vicriviroc Malate is a second generation orally active CCR5 antagonist, which is also a potent inhibitor of HIV-1 entry into target cells, with a mean IC50 =0.46 nM and IC50 =1~10 nM to HIV isolates (n=52).

Cat. No.

A11127

CAS No.

624733-88-6

MK-0812

MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes and low nM in the chemotaxis assay. It has good PK profiles in preclinical species and demonstrated efficacy in animal models.

Cat. No.

A11104

CAS No.

887401-93-6

INCB 3284 dimesylate

Synonyms: INCB3284

INCB 3284 dimesylate is a potent, selective hCCR2 antagonist that exhibits potenct antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity.

Cat. No.

A11136

CAS No.

857679-55-1

(Rac)-PF-4136309 ((Rac)-INCB8761)

Synonyms: INCB-8761; PF4136309; (Rac)-INCB8761

INCB8761(PF-4136309) is a potent, selective, and orally bioavailable CCR2 antagonist.

Cat. No.

A11465

CAS No.

1262238-11-8

INCB3344

INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.

Cat. No.

A12175

CAS No.

1240516-71-5

GSK2239633A

GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96±0.11.

Cat. No.

A13380

CAS No.

226226-39-7

Teijin compound 1

Teijin compound 1 is a specific CCR 2 antagonist with IC50s of 24 and 180 nM in chemotaxis and binding assay, respectively.

Cat. No.

A13846

CAS No.

229005-80-5

TAK-779

TAK-779 is a novel, potent and selective small-molecule antagonists of CCR5 with the IC50 value of 1.4nM in binding assay.

Cat. No.

A14409

CAS No.

217645-70-0

BX471

BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1), exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.

Cat. No.

A15127

CAS No.

1341224-83-6

PF-4136309

Synonyms: INCB8761

PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

Cat. No.

A15227

CAS No.

300816-15-3

RS 504393

RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 uM for inhibition of human recombinant CCR2b and CCR1 receptors respectively).

Cat. No.

A15276

CAS No.

599179-03-0

Vicriviroc maleate

Synonyms: Sch-417690; SCH-D

Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1.

Cat. No.

A17040

CAS No.

1286279-29-5

BMS-813160

BMS-813160 is a potent and selective CCR2/CCR5 antagonist with potential immunomodulating and antineoplastic activities.

Cat. No.

A18471

CAS No.

2206788-99-8

CCR4 antagonist 2

CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues.

Cat. No.

A18659

CAS No.

1228111-63-4

PF-04634817

Synonyms: PF-4634817; PF4634817.

PF-04634817 is an orally administered CCR2 and CCR5 chemokine receptor antagonist, for the treatment of diabetic nephropathies and diabetic macular oedema.

Cat. No.

A18747

CAS No.

1295298-26-8

BI-639667

BI-639667 is a potent and selective antagonist of human CCR1.

Cat. No.

A19143

CAS No.

929300-19-6

AZ084

AZ084 is a potent, selective, allosteric and oral active CCR8 antagonist, with a Ki of 0.9 nM. Has potential to treat asthma.

Cat. No.

A19274

CAS No.

58816-69-6

SB297006

SB297006 is a CCR3 antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells.

Cat. No.

A19318

CAS No.

1683534-96-4

CCR2 antagonist 1

CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.

Cat. No.

A20039

CAS No.

408303-43-5

GW 766994

Synonyms: GW 994,GW-994; GW994

GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis.

Cat. No.

A20439

CAS No.

716354-86-8

CCR5 antagonist 1

CCR5 antagonist 1 is a CCR5 antagonist which can inhibit HIV replication extracted from WO 2004054974 A2.

Cat. No.

A20467

CAS No.

1380100-86-6

CCR2 antagonist 3

CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist.

Cat. No.

A20618

CAS No.

333994-00-6

TAK-220

TAK-220 is a selective and orally bioavailable CCR5 antagonist.

Cat. No.

A20644

CAS No.

512177-83-2

CCR2-RA-[R]

CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM.