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Mycobacterium tuberculosis

Mycobacterium tuberculosis research compounds act on enzymes and proteins that the tuberculosis bacterium depends on. The genome of the laboratory strain H37Rv, sequenced in 1998, encodes an unusually large set of enzymes for lipid metabolism. Several entries inhibit decaprenylphosphoryl-β-D-ribose 2′-epimerase (DprE1), an enzyme required for arabinan synthesis in the cell wall. Benzothiazinones, represented here by BTZ043 (BTZ038, BTZ044) Racemate, were shown in 2009 to kill the bacterium by blocking this step. AZ7371 and DprE1-IN-8 are listed as further inhibitors of the same enzyme. PXYC1 and PXYC2 are antagonists of ribosomal protein S1 (RpsA), and MtTMPK-IN-8 inhibits mycobacterial thymidylate kinase. Cefsulodin sodium hydrate is listed as an inhibitor of mycobacterial protein tyrosine phosphatase B (mPTPB), a secreted virulence factor.

Items 76-77 of 77

  • MmpL3-IN-5
    Cat. No.
    A50368
    CAS No.
    1432641-65-0

    MmpL3-IN-5

    MmpL3-IN-5 is a specific inhibitor of the MmpL3 protein, which plays a critical role in the cell wall biogenesis of Mycobacterium tuberculosis. It demonstrates significant antitubercular activity, exhibiting a pMIC of 7.0 μM against the H37Rv strain of Mycobacterium tuberculosis. This compound is valuable for research focused on the development of new therapeutic strategies for tuberculosis.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • Tuberculosis inhibitor 12
    Cat. No.
    A50545
    CAS No.
    793729-44-9

    Tuberculosis inhibitor 12

    Tuberculosis Inhibitor 12 is an oxadiazole derivative designed to inhibit Mycobacterium tuberculosis. At a concentration of 20 µM, it demonstrates significant inhibition rates of 82% and 78% in 7H9-Tw-OADC media. This compound serves as a valuable tool for research applications aimed at studying tuberculosis and discovering novel therapeutic strategies.

    In stock View Details
    1 mg
    $30.00
    5 mg
    $65.00
    All 5 sizes

Items 76-77 of 77

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