Ebola Virus (Filovirus)

Cat. No.

A27060

CAS No.

483-17-0

Cephaeline

Synonyms: (-)-Cephaeline; NSC 32944 free base

Cephaeline is a phenolic alkaloid derived from the roots of Cephaelis ipecacuanha, functioning as a potent inhibitor of Zika virus (ZIKV) and Ebola virus (EBOV) infections. It induces histone H3 acetylation, playing a role in epigenetic regulation, and has been shown to induce ferroptosis in mucoepidermoid carcinoma cancer stem cells by inhibiting NRF2. This makes Cephaeline a valuable reagent for researchers studying antiviral mechanisms and ferroptosis in cancer therapy.

Cat. No.

A34125

CAS No.

1018148-68-9

CP19

CP19 is a histamine receptor antagonist that functions as an entry inhibitor for both Ebolavirus (EBOV) and Marburgvirus (MARV), demonstrating IC50 values of 3.4 μM and 29.5 μM, respectively. With selectivity index (SI) values of 29.4 for EBOV and 3.4 for MARV, CP19 exhibits notable antiviral activity. This compound is valuable for research into viral entry mechanisms and the development of antiviral strategies targeting EBOV and MARV.

Cat. No.

A36458

CAS No.

752216-12-9

EBOV-IN-11

EBOV-IN-11 is a potent inhibitor of protein phosphatase 1 (PP1), exhibiting Kd values of 1.88 nM for wild-type PP1 and 8.01 nM for the quadruple-mutant variant. This compound effectively inhibits the replication and transcription of the EBOV-eGFP virus, demonstrating significant antiviral activity. EBOV-IN-11 is suitable for research applications related to Ebola virus infection and the exploration of PP1-related pathways in viral pathogenesis.

Cat. No.

A50845

CAS No.

1335113-30-8

EBOV-IN-1

EBOV-IN-1 is an adamantane dipeptide piperazine that functions as an inhibitor of the Ebola virus (EBOV). It selectively targets Niemann-Pick C1 (NPC1), thereby preventing the interaction between NPC1 and the EBOV glycoprotein (GP) that facilitates viral entry into host cells. This compound demonstrates significant antiviral activity, inhibiting pseudotyped EBOV infection with an IC50 value of 13 nM, making it a valuable tool for research related to EBOV infection mechanisms and potential therapeutic interventions.

Cat. No.

A50846

CAS No.

2479465-67-1

EBOV/MARV-IN-1

EBOV/MARV-IN-1 is a potent inhibitor targeting the Ebola virus (EBOV) and Marburg virus (MARV). It demonstrates broad-spectrum antiviral activity, with effective concentrations (EC50) of 0.31 µM and 0.82 µM for EBOV and MARV, respectively. Additionally, this compound exhibits low cytotoxicity, with a selectivity index exceeding 100 in HeLa cells, making it suitable for research applications in viral pathogenesis and therapeutic development against filoviruses.

Cat. No.

A50847

CAS No.

314035-79-5

Antiviral agent 75

Antiviral Agent 75 is a selective inhibitor of Ebolavirus (EBOV) and Bundibugyo ebolavirus (BDBV), exhibiting IC50 values of 0.11 μM and 0.75 μM, respectively. This compound is valuable for investigating filovirus infections and their mechanisms, thereby facilitating research into potential therapeutic strategies against these pathogens. Its efficacy makes it an important tool for further studies in the field of antiviral drug development.

Cat. No.

A50848

CAS No.

2687244-84-2

EBOV/MARV-IN-2

EBOV/MARV-IN-2 is an inhibitor of Ebolavirus (EBOV) with an IC50 of 0.9 μM and Marburg virus (MARV) with an IC50 of 2.7 μM. This compound demonstrates significant antiviral activity, making it a valuable tool for research focused on virology and the development of therapeutic strategies against filovirus infections. Its ability to inhibit these viruses positions it for use in studies assessing antiviral mechanisms and potential treatments for hemorrhagic fevers.

Cat. No.

A50849

CAS No.

286854-12-4

EBOV-IN-8

EBOV-IN-8 is an effective inhibitor targeting the Ebola virus (EBOV). It demonstrates significant antiviral activity by inhibiting infection of Ebola pseudotyped virus (pEBOV) with an IC50 of 62.1% at 10 μM. This compound is valuable for research applications related to viral pathogenesis and the development of therapeutics against Ebola virus infection.

Cat. No.

A50853

CAS No.

68207-15-8

EBOV-IN-5

EBOV-IN-5 is an antiviral agent that targets the Ebola virus (EBOV) by inhibiting the interaction between the EBOV glycoprotein (EBOV-GPcl) and the Niemann-Pick C1 (NPC1) receptor. This interference prevents viral fusion and entry into host cells, thereby reducing infection rates. EBOV-IN-5 is primarily utilized in research settings to study EBOV pathogenesis and to develop potential therapeutic strategies against Ebola virus infections.

Cat. No.

A50854

CAS No.

2687245-05-0

EBOV/MARV-IN-3

EBOV/MARV-IN-3 is a potent inhibitor of both Ebola Virus (EBOV) and Marburg Virus (MARV), exhibiting IC50 values of 0.5 µM and 1.2 µM, respectively. This compound effectively binds to a hydrophobic pocket near EBOV residue Y517, demonstrating significant antiviral activity. EBOV/MARV-IN-3 is primarily utilized in research applications focused on viral therapeutics and the study of viral pathogenesis.

Cat. No.

A50855

CAS No.

2896193-43-2

EBOV-IN-4

EBOV-IN-4 is a benzothiazepine that functions as a potent inhibitor of the Ebola virus (EBOV), demonstrating 64.9% inhibition of the EBOV-GP pseudotype virus at a concentration of 10 μM. This compound is specifically tailored for antiviral research applications targeting EBOV, with no activity observed against African swine fever virus (ASFV).

Cat. No.

A50856

CAS No.

1196-00-5

(-)-Isopinocampheol (l-Isopinocampheol)

Synonyms: l-Isopinocampheol

(-)-Isopinocampheol functions as a filovirus inhibitor, demonstrating significant anti-filovirus activity. Its derivatives have shown the ability to inhibit infection by Ebola and Marburg viruses, likely through interaction with viral surface glycoproteins. Additionally, this compound exhibits affinity for lysosomal structures, which may contribute to its bioactivity.

Cat. No.

A50858

CAS No.

68207-16-9

EBOV-IN-7

EBOV-IN-7 is a selective inhibitor of the Ebola virus (EBOV), displaying an IC50 of 2.04 μM against EBOV glycoprotein (EBOV-GP) pseudotyped virus. This compound disrupts the interaction between EBOV-GP and NPC1, which is crucial for viral entry. Additionally, EBOV-IN-7 exhibits inhibitory effects on cancer cell proliferation, making it a valuable tool for research in virology and oncology.

Cat. No.

A50859

CAS No.

2896193-40-9

EBOV-IN-3

EBOV-IN-3 is a benzothiazepine compound that targets the Ebola virus with antiviral activity. Exhibiting an IC50 value of 0.37 μM, it demonstrates potent inhibition of pEBOV replication. This compound is valuable for research into antiviral therapies and mechanisms of action against Ebola virus infections.

Cat. No.

A50861

CAS No.

1252187-41-9

pEBOV-IN-1

pEBOV-IN-1 is a potent inhibitor of pseudotyped Ebola virus (pEBOV), demonstrating an EC50 value of 0.38 μM. This compound is essential for research aimed at understanding Ebola virus entry mechanisms and developing therapeutic strategies. Its application extends to virology and infectious disease studies, facilitating the evaluation of antiviral efficacy and screening of potential drug candidates.

Cat. No.

A50862

CAS No.

3054659-65-0

Antiviral agent 59

Antiviral Agent 59 is a selective filovirus inhibitor targeting a broad spectrum of filoviruses, including Ebola virus (EBOV), Sudan virus (SUDV), and Marburg virus (MARV). This compound demonstrates a strong antiviral activity while maintaining low off-target effects, making it a valuable tool for research into filovirus replication and pathogenesis. It is suitable for studies aimed at elucidating viral mechanisms and developing therapeutic strategies against filoviral infections.

Cat. No.

A50864

CAS No.

3032283-85-2

EBOV-GP-IN-1

EBOV-GP-IN-1 is a potent inhibitor of Ebola virus entry, targeting the envelope glycoprotein (EBOV-GP) with an IC50 of 0.05 μM. This compound is effective in blocking the virus from entering host cells, making it a valuable tool for research on Ebola virus infection pathways. Its application is crucial for studies focused on antiviral strategies and therapeutic development against Ebola virus disease.

Cat. No.

A53610

CAS No.

3040400-51-6

EBOV-IN-10

EBOV-IN-10 is a potent inhibitor of the Ebola virus (EBOV), exhibiting an EC50 value of 0.19 μM. This compound demonstrates significant antiviral activity, making it a valuable tool in research focused on combating Ebola virus infection. EBOV-IN-10 can be utilized in studies exploring therapeutic strategies and mechanisms of action against EBOV.