Mycobacterium tuberculosis | Adooq Bioscience

Cat. No.: A48856

CAS No.: 2413974-52-2

Mt KARI-IN-2

Mt KARI-IN-2 is a selective inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), exhibiting a Ki value of 2.02 μM. This compound demonstrates significant inhibitory activity against the Mtb H37Rv strain, with a minimum inhibitory concentration (MIC) of 0.78 μM, while exhibiting low cytotoxicity in HEK cells (IC50 > 86 μg/mL). Mt KARI-IN-2 serves as a valuable tool for research into tuberculosis treatment strategies and the mechanistic study of Mtb KARI.

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Cat. No.: A48884

CAS No.: 2680554-46-3

PXYD3

PXYD3 is an antagonist of ribosomal protein S1 (RpsA), exhibiting dissociation constants (Kds) of 5.66 μM and 6.91 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA is crucial for the trans-translation process in Mycobacterium tuberculosis, making PXYD3 a valuable tool for researching antibiotic mechanisms and developing potential therapeutic agents against this pathogen. This compound facilitates studies on ribosomal function and interactions, contributing to the understanding of bacterial resistance mechanisms.

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Cat. No.: A49009

CAS No.: 2764818-29-1

Antitubercular agent-31

Antitubercular agent-31 is a potent DprE1 inhibitor demonstrated to possess a minimum inhibitory concentration (MIC) of 0.03 μM against Mycobacterium tuberculosis H37Rv. With an IC50 value of 1.1 μM, this compound effectively disrupts the enzymatic activity of DprE1, making it a valuable tool for research in tuberculosis biology and drug discovery. It offers potential for further exploration in the development of new antitubercular therapies.

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Cat. No.: A49019

CAS No.: 2225889-49-4

MtTMPK-IN-4

MtTMPK-IN-4 is a specific inhibitor of mycobacterium tuberculosis thymidylate kinase (MtTMPK), exhibiting an IC50 of 6.1 μM. This compound demonstrates significant antibacterial activity, making it a valuable tool in the study of tuberculosis. Additionally, MtTMPK-IN-4 acts as a potent inhibitor of tyrosinase, expanding its potential applications in biochemical research and drug development targeting bacterial infections.

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Cat. No.: A49022

CAS No.: 2906099-98-5

DprE1-IN-9

DprE1-IN-9 is a reversible inhibitor of DprE1, effectively targeting its receptor cavity. This compound exhibits potent antimycobacterial activity, demonstrating a minimum inhibitory concentration (MIC) of 0.18 µg/mL against the non-pathogenic strain H37Ra, as well as strong efficacy against the pathogenic H37Rv and various clinical multidrug-resistant (MDR) and extensively drug-resistant (XDR) isolates. DprE1-IN-9 is valuable for research applications focused on tuberculosis and related infections.

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Cat. No.: A49025

CAS No.: 2799607-71-7

MtTMPK-IN-2

MtTMPK-IN-2 is a selective inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtTMPK), exhibiting an IC50 value of 1.1 μM. This compound demonstrates effective antimicrobial activity against Mycobacterium tuberculosis strain H37Rv, with a minimum inhibitory concentration (MIC) of 12.5 μM. Additionally, MtTMPK-IN-2 shows cytotoxic effects in human fibroblast MRC-5 cells, with an EC50 value of 6.1 μM. This reagent is valuable for research focused on tuberculosis and the development of novel therapeutic strategies against this pathogen.

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Cat. No.: A49040

CAS No.: 2290534-93-7

MmpL3-IN-1

MmpL3-IN-1 is a potent inhibitor of the Mycobacterial membrane protein large 3 (MmpL3). It exhibits strong anti-tuberculosis activity, with a minimal inhibitory concentration (MIC) of less than 0.016 μg/mL against Mycobacterium tuberculosis. This compound is valuable for research on drug-resistant tuberculosis and elucidating MmpL3's role in mycobacterial lipid transport and pathogenesis.

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Cat. No.: A49046

CAS No.: 2799607-58-0

MtTMPK-IN-1

MtTMPK-IN-1 is a selective inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtTMPK), demonstrating a potent inhibitory effect with an IC50 value of 2.5 μM. This compound exhibits moderate to weak anti-tubercular activity against the Mtb H37Rv strain while maintaining low cytotoxicity in human fibroblast cells (MRC-5). MtTMPK-IN-1 serves as a valuable tool for tuberculosis research, aiding in the exploration of therapeutic strategies targeting MtTMPK.

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Cat. No.: A49064

CAS No.: 121041-08-5

Tuberculosis inhibitor 6

Tuberculosis Inhibitor 6 (compound 2c) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that targets Mycobacterium tuberculosis and Mycobacterium marinum. This compound exhibits potent antimicrobial activity, with a minimum inhibitory concentration (MIC90) of ≤1.66 μM against M. tuberculosis and 2.65 μM against M. marinum. It is a valuable research tool for studying tuberculosis and developing therapeutics for mycobacterial infections.

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Cat. No.: A49065

CAS No.: 2413974-53-3

Mt KARI-IN-4

Mt KARI-IN-4 is a potent inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), with a Ki value of 5.48 μM. This compound demonstrates significant inhibitory activity against Mtb H37Rv, exhibiting a minimum inhibitory concentration (MIC) of 0.78 μM. Additionally, Mt KARI-IN-4 shows low cytotoxicity in HEK cells, with an IC50 greater than 72 μg/mL, making it a promising candidate for further research in tuberculosis therapeutics.

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Cat. No.: A49073

CAS No.: 2306039-13-2

Mtb-IN-4

Mtb-IN-4 is an isoxazole compound that targets Mycobacterium tuberculosis (Mtb) with an IC50 of 0.70 μM. It effectively inhibits Mtb respiration and biofilm formation within macrophages, making it a valuable tool for studying tuberculosis. Additionally, Mtb-IN-4 enhances the activity of the antibiotic isoniazid against isoniazid-resistant Mtb mutants, providing insights into new therapeutic strategies for combating drug-resistant tuberculosis.

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Cat. No.: A49084

CAS No.: 2411741-01-8

Antituberculosis agent-2

Antituberculosis agent-2 is a targeted therapeutic compound effective against both drug-sensitive and multidrug-resistant strains of Mycobacterium tuberculosis. It exhibits notable anti-tuberculosis activity, demonstrated by minimum inhibitory concentrations (MIC) of 0.454, 1.757, and 1.644 μg/mL against M. tuberculosis strains H37Rv, 13946, and 14862, respectively. This compound possesses favorable stability in mouse and human microsomes, exhibits low cytotoxicity, and shows acceptable oral bioavailability, making it a valuable candidate for further research in tuberculosis treatment.

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Cat. No.: A49112

CAS No.: 2413974-69-1

Mt KARI-IN-5

Mt KARI-IN-5 is a potent inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), exhibiting a Ki value of 4.72 μM. This compound demonstrates significant inhibitory activity against Mtb H37Rv, with a minimum inhibitory concentration (MIC) of 1.56 μM, while exhibiting low cytotoxicity in HEK cells (IC50 > 64 μg/mL). Mt KARI-IN-5 is a valuable tool for research into tuberculosis treatment and the exploration of metabolic pathways in pathogenic mycobacteria.

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Cat. No.: A49141

CAS No.: 912780-51-9

C215

C215 is a potent inhibitor of MmpL3, serving as an anti-infection agent. It exhibits significant activity against Mycobacterium tuberculosis, demonstrating an IC90 of 16 μM, alongside effective performance against M. tuberculosis within macrophages. C215 displays limited non-specific toxicity towards mammalian cells, making it a valuable tool for research in tuberculosis treatment and related infectious disease studies.

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Cat. No.: A49170

CAS No.: 3105177-29-2

MSU-44147

MSU-44147 is a selective MmpL3 inhibitor with potent antimicrobial activity against Mycobacterium abscessus. This compound effectively reduces trehalose dimycolate levels by disrupting MmpL3 function, impairing biofilm formation, and decreasing the viability of the bacteria, including intracellular strains. With low cytotoxicity to eukaryotic cells and a narrow antimicrobial spectrum, MSU-44147 is ideal for research on multidrug-resistant mycobacterial infections and can exhibit additive or synergistic effects when combined with other antibiotics.

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Cat. No.: A49187

CAS No.: 1639438-67-7

MmpL3-IN-3

MmpL3-IN-3 is a specific inhibitor of the MmpL3 protein, a vital target in the treatment of tuberculosis. It demonstrates a minimum inhibitory concentration (MIC) of 0.1 μM against the Mycobacterium tuberculosis strain H37Rv, indicating potent anti-tubercular activity. Additionally, MmpL3-IN-3 exhibits favorable metabolic stability in mouse liver microsomes, making it a valuable tool for research focused on tuberculosis therapeutics.

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Cat. No.: A49226

CAS No.: 3035894-73-3

PptT-IN-2

PptT-IN-2 is a potent inhibitor of phosphopantetheinyl transferase (PptT), exhibiting an IC50 value of 2.5 μM. PptT is a critical enzyme involved in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. This compound is valuable for research into tuberculosis, particularly in studies focusing on the therapeutic modulation of lipid biosynthesis and virulence factor expression.

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Cat. No.: A49237

CAS No.: 1364914-72-6

LeuRS-IN-1

LeuRS-IN-1 is a selective inhibitor of Mycobacterium tuberculosis leucyl-tRNA synthetase (M.tb LeuRS) with high potency, exhibiting an IC50 value of 0.06 μM. It also demonstrates a Kd of 0.075 μM for M.tb LeuRS, making it a valuable tool for studying bacterial protein synthesis. Additionally, LeuRS-IN-1 inhibits human cytoplasmic leucyl-tRNA synthetase with an IC50 of 38.8 μM and affects protein synthesis in HepG2 cells (EC50=19.6 μM), highlighting its potential for research into both microbial and human protein synthesis pathways.

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Cat. No.: A49264

CAS No.: 2987482-25-5

MtTMPK-IN-7

MtTMPK-IN-7 is an inhibitor that specifically targets M. tuberculosis thymidylate kinase (MtbTMPK) with an IC50 value of 47 μM. This compound demonstrates sub-micromolar activity against mycobacterial strains, with minimal cytotoxicity (MICs of 2.3 to 4.7 μM). MtTMPK-IN-7 is a valuable tool for research applications focused on tuberculosis and the development of novel antimycobacterial therapies.

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Cat. No.: A49285

CAS No.: 2948309-57-5

PptT-IN-4

PptT-IN-4 is a potent inhibitor of PptT, with an IC50 value of 0.71 μM. This compound effectively inhibits Mycobacterium tuberculosis strain H37Rv, displaying a minimum inhibitory concentration (MIC) of 42 μM. Additionally, PptT-IN-4 shows inhibitory activity on hERG, hCav1.2, and hNav1.5 ion channels, with respective IC50 values of 11 μM, 8.1 μM, and 6.9 μM. This makes PptT-IN-4 significant for research in tuberculosis treatment and cardiovascular safety pharmacology.

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Cat. No.: A49305

CAS No.: 2095636-19-2

Antituberculosis agent-10

Antituberculosis agent-10 is a potent antibacterial compound that targets Mycobacterium tuberculosis, demonstrating an effective minimum inhibitory concentration (MIC) of 0.3 μM. Its primary mechanism involves the inhibition of protein synthesis through binding to the 50S ribosomal subunit in the bacterial machinery. This agent is suitable for research applications focusing on tuberculosis and related infectious diseases, offering potential insights into therapeutic strategies.

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Cat. No.: A49311

CAS No.: 55648-39-0

4-Hydroxyoxyphenbutazone

4-Hydroxyoxyphenbutazone is a potent inhibitor of Mycobacterium tuberculosis (Mtb), demonstrating efficacy against both replicating and nonreplicating forms, including strains resistant to conventional treatments. This compound significantly reduces cytokine production, exhibiting immunosuppressive properties that can be leveraged in research related to rheumatoid arthritis and other inflammatory conditions. Its unique mechanism makes it a valuable tool for exploring therapeutic strategies against Mtb and associated diseases.

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Cat. No.: A49331

CAS No.: 2219338-48-2

Polyketide synthase 13-IN-2

Polyketide Synthase 13-IN-2 is a specific inhibitor of polyketide synthase 13, targeting Mycobacterium tuberculosis. It demonstrates significant biological activity with a minimum inhibitory concentration (MIC) of 0.25 μg/mL. This compound is valuable for research applications focusing on tuberculosis treatment and the study of polyketide synthase function in pathogenic bacteria.

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Cat. No.: A49358

CAS No.: 3052302-61-8

Mtb-IN-3

Mtb-IN-3 is a selective inhibitor of Mycobacterium tuberculosis (Mtb), exhibiting potent in vitro antimycobacterial activity with an absence of cytotoxic effects. This compound demonstrates effectiveness in reducing colony-forming units in the spleen within murine models of tuberculosis. Mtb-IN-3 serves as a valuable tool for research into antimycobacterial therapies and the mechanisms underlying tuberculosis infection.

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Cat. No.: A49359

CAS No.: 1839081-05-8

BTZ-N3

BTZ-N3 is a potent reversible and noncovalent inhibitor of decaprenylphosphoryl-β-d-ribose 2′ oxidase (DprE1), a key enzyme in mycobacterial cell wall synthesis. This compound exhibits significant anti-tuberculosis activity, making it valuable for research focused on combating mycobacterial infections. Its inhibitory effects on DprE1 contribute to the exploration of new therapeutic strategies against tuberculosis.

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