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Motilin Receptor (MLNR)

Motilin receptor agonists and antagonists act on the receptor for motilin, a gut peptide hormone. Motilin is a 22-amino acid peptide released from endocrine cells of the upper small intestine. Its periodic release starts phase III of the migrating motor complex, a band of contractions that sweeps the empty stomach and gut. The motilin receptor (MLNR), previously known as G protein-coupled receptor 38 (GPR38), was identified in 1999 as a G protein-coupled receptor of the human gastrointestinal tract. Agonists derived from macrolide antibiotics, called motilides, act on the same receptor. The category holds Motilin, human, porcine and Motilin, canine, the small-molecule agonist camicinal and the motilide EM-523. MA-2029 and ANQ-11125 are listed as antagonists that block motilin-induced responses.

3 Items

  • MA-2029
    Cat. No.
    A61940
    CAS No.
    287206-61-5

    MA-2029

    MA-2029 is a selective, orally active antagonist of the motilin receptor, exhibiting an IC50 of 4.9 nM. It demonstrates high selectivity for the motilin receptor compared to a variety of other receptors and ion channels. This compound is particularly relevant for research into gastrointestinal disorders linked to impaired gastrointestinal motility, providing a valuable tool for studying motility-related pathophysiology and potential therapeutic interventions.

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    1 mg
    $440.00
    5 mg
    $1,130.00
    All 6 sizes
  • ANQ-11125
    Cat. No.
    A61947
    CAS No.
    153966-48-4

    ANQ-11125

    ANQ-11125 is a potent and selective antagonist of motilin, exhibiting a pKd of 8.24. This compound effectively inhibits motilide-induced contractions in vitro in rabbit models, making it a valuable tool for studying gastrointestinal motility and related disorders. ANQ-11125 has potential applications in research focused on gastrointestinal physiology and pharmacology.

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    Out of stock

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  • RWJ-68022
    Cat. No.
    A61954
    CAS No.
    223442-22-6

    RWJ-68022

    RWJ-68022 is a cyclopentene derivative that acts as a motilin receptor antagonist. It effectively competes with motilin and erythromycin for binding to the motilin receptor site. This compound is valuable in research related to gastrointestinal disorders, providing insights into motilin's role in digestive physiology and its potential therapeutic applications.

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    Out of stock

    All 3 sizes

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