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Neuromedin U Receptor (NMUR)

Neuromedin U receptor ligands act on two receptors that mediate the effects of the peptide neuromedin U. Neuromedin U (NMU) was isolated in 1985 from porcine spinal cord as a peptide that contracts uterine smooth muscle and raises blood pressure. In 2000, two G protein-coupled receptors for NMU were identified, and central NMU was found to reduce food intake. Neuromedin U receptor 1 (NMUR1) is expressed mainly in peripheral tissues, whereas neuromedin U receptor 2 (NMUR2) is enriched in the brain. Neuromedin U, rat is the natural peptide ligand, and CPN-116 and NY0116 are listed as NMUR2 agonists. CPN-267 is annotated as an NMUR1 agonist, whereas R-PSOP and CPN-351 are antagonists of NMUR2 and NMUR1, respectively.

2 Items

  • R-PSOP
    Cat. No.
    A62152
    CAS No.
    1185189-97-2

    R-PSOP

    R-PSOP is a potent and selective nonpeptidic antagonist of the neuropeptide receptor NMUR2. With binding affinities (Kis) of 52 nM for human and 32 nM for rat NMUR2, R-PSOP demonstrates effective receptor inhibition. Its moderate central nervous system penetration makes it a valuable tool for investigating eating disorders, obesity, pain mechanisms, and stress-related disorders in research settings.

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    5 mg
    $330.00
    10 mg
    $570.00
    All 5 sizes
  • CPN-351
    Cat. No.
    A62158
    CAS No.
    3057171-63-5

    CPN-351

    CPN-351 is a selective antagonist of the human neuropeptide FF receptor 1 (NMUR1), exhibiting a pA2 of 7.35. Its antagonistic potency towards NMUR1 is significantly greater than its effect on NMUR2, being approximately ten times more effective. CPN-351 is a valuable tool for investigating inflammatory processes and the role of neuropeptide signaling in various biological systems.

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    All 3 sizes

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