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Neuropeptide S Receptor

Neuropeptide S receptor (NPSR) ligands are research compounds for a neuronal G protein-coupled receptor. Receptor signaling is associated with intracellular second messengers and is studied in arousal, stress responses and neural circuit function. ML154 is listed as an antagonist, while R06039-691 and R06039-641 are annotated as agonists. The category also includes other receptor-related modulators. Differences in the listed functional classes provide context for selecting compounds when examining receptor pharmacology and downstream signaling in experimental systems.

1 Item

  • ML154
    Cat. No.
    A62176
    CAS No.
    1345964-89-7

    ML154

    Synonyms: NCGC84

    ML154 is a selective non-peptide antagonist of the neuropeptide S receptor (NPSR), demonstrating efficient brain penetration. This compound effectively inhibits NPS-induced cellular responses, including calcium influx, cAMP accumulation, and ERK phosphorylation, with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively. ML154 is a valuable tool for investigating the role of NPSR in various physiological and pathological processes.

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    1 mg
    $40.00
    2 mg
    $60.00
    All 8 sizes

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