-
-
- Cat. No.
- A26273
LEAP-2
Synonyms: Human liver expressed antimicrobial peptide-2
LEAP-2 is a GHS-R1a antagonist with a reported IC50 of 6.0 nM. This peptide effectively suppresses the orexigenic effects of ghrelin, attenuating ghrelin-induced growth hormone release and reducing basal food intake. Additionally, LEAP-2 demonstrates antimicrobial activity against various microbial model organisms. This compound is useful for research applications focused on obesity, metabolic disorders, and infectious diseases.
In stock View Details -
- Cat. No.
- A60535
YIL781 hydrochloride
YIL781 hydrochloride is a potent antagonist of the ghrelin receptor (GHSR). This compound has been shown to significantly improve glucose homeostasis in rat models, demonstrating its potential in metabolic research. YIL781 hydrochloride effectively inhibits the calcium response triggered by ghrelin, with pIC50 values of 7.90 and 8.27, indicating robust bioactivity in a research context.
In stock View Details -
- Cat. No.
- A60536
JMV 2959
JMV 2959 is an antagonist of the growth hormone secretagogue receptor type 1a (GHS-R1a), exhibiting an IC50 value of 32 nM. This compound is utilized in research aimed at elucidating the roles of GHS-R1a in growth hormone regulation and metabolic processes. Its potent inhibitory activity makes it a valuable tool for studies related to obesity, metabolic disorders, and the endocrine system.
In stock View Details -
- Cat. No.
- A60539
Cortistatin-8
Synonyms: PCFWKTCK
Cortistatin-8 (CST-8; PCFWKTCK) is a synthetic analogue of the neuropeptide cortistatin that acts as an antagonist of the ghrelin receptor (GHS-R1a). This compound counteracts the effects of ghrelin on gastric acid secretion and influences growth hormone release from somatotroph cells. With no binding affinity for somatostatin receptors (SST-R), Cortistatin-8 is specifically designed for research applications investigating the modulation of ghrelin signaling both in vitro and in vivo.
In stock View Details -
- Cat. No.
- A60540
JMV 2959 hydrochloride
JMV 2959 hydrochloride is a selective antagonist of the growth hormone secretagogue receptor 1a (GHS-R1a), exhibiting an IC50 of 32±3 nM in LLC-PK1 cellular assays. This compound is valuable for studies investigating the modulation of growth hormone release and its implications in metabolic disorders, obesity, and appetite regulation. Its efficacy as a GHS-R1a antagonist makes it a potent tool for exploring the signaling pathways associated with this receptor.
In stock View Details -
- Cat. No.
- A60546
(αR,8aS)-GSK1614343
(αR,8aS)-GSK1614343 is an isomer of GSK1614343, acting as a potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors. This compound effectively modulates the GH secretagogue pathway, making it valuable for research focused on obesity, metabolism, and growth-related disorders. Its distinct isomeric configuration provides unique properties for investigations into receptor biology and therapeutic target validation.
In stock View Details -
- Cat. No.
- A60554
GSK1614343
GSK1614343 is a selective antagonist of growth hormone secretagogues type 1a (GHS1a) receptors. It effectively inhibits the calcium response induced by ghrelin, exhibiting a pIC50 value of 7.90. This compound serves as a valuable tool for exploring the physiological roles of the ghrelin signaling pathway in various research applications, particularly in rodent models.
Out of stock
All 3 sizes -
- Cat. No.
- A60573
Tezusomant
Tezusomant is a growth hormone receptor antagonist that effectively inhibits the activity of growth hormone. This compound is instrumental in investigating conditions related to excessive growth hormone secretion, such as acromegaly and related endocrine disorders. Tezusomant facilitates research aimed at understanding the underlying mechanisms of these diseases and exploring potential therapeutic interventions.
Out of stock
All 3 sizes -
- Cat. No.
- A60574
JV-1-36
JV-1-36 is a growth hormone-releasing hormone (GHRH) antagonist. This compound effectively inhibits the production of reactive oxygen species in A549 lung cancer cells, making it a valuable tool for investigating the biological effects of GHRH antagonists. Research applications include in vitro studies focused on cancer biology and role of GHRH in tumorigenesis.
Out of stock
All 3 sizes -
- Cat. No.
- A60578
JMV 3002
JMV 3002 is a potent antagonist of the growth hormone secretagogue receptor (GHSR). It exhibits significant biological activity by inhibiting hexarelin-stimulated food intake in rat models, achieving up to 98% reduction at a dose of 80 μg/kg. JMV 3002 does not induce release of growth hormone on its own, nor does it inhibit hexarelin-stimulated growth hormone secretion in infant rats at a dose of 160 μg/kg. This compound is valuable for research focused on energy homeostasis and the regulation of appetite.
In stock View Details -
- Cat. No.
- A60580
JMV 3008
JMV 3008 is a GHS-R1a antagonist with an IC50 of 5.6 nM, effectively inhibiting the growth hormone secretagogue receptor 1a. This compound demonstrates potential in the study of metabolic disorders, including diabetes and obesity, by modulating appetite and energy homeostasis. Research involving JMV 3008 can contribute valuable insights into therapeutic strategies targeting these diseases.
In stock View Details