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NPY Receptor

NPY receptor antagonists act on the Y1, Y2, Y5 and related receptors for neuropeptide Y (NPY). Neuropeptide Y was isolated from brain in 1982 as a peptide related to peptide tyrosine tyrosine (PYY) and pancreatic polypeptide. Its receptors are G protein-coupled receptors that regulate feeding, anxiety, vascular tone and neurotransmitter release. In 1996 a Y5 subtype was cloned and implicated in NPY-induced food intake. BIIE 0246 and JNJ-31020028 are Y2 receptor antagonists, and BMS-193885 blocks the Y1 receptor. L 152804 and CGP71683 hydrochloride are antagonists of the Y5 receptor subtype. The list also holds galanin receptor ligands, such as Galanin (1-30) (human) and HT-2157, and the natriuretic peptide nesiritide.

1 Item

  • NPY Y2 antagonist 2
    Cat. No.
    A62260
    CAS No.
    1262495-12-4

    NPY Y2 antagonist 2

    NPY Y2 Antagonist 2 is a selective inhibitor of the neuropeptide Y receptor Y2, exhibiting pKi values of 6.8 nM and 7.2 nM in human and rat brain tissues, respectively. This compound effectively blocks the NPY Y2-mediated negative feedback, leading to increased endogenous NPY release and enhanced activation of Y1 receptors. Its ability to penetrate the blood-brain barrier, along with moderate in vivo clearance and a favorable brain/plasma ratio, makes NPY Y2 Antagonist 2 a valuable tool for investigating mood disorders, alcohol withdrawal-related anxiety, and social anxiety linked to nicotine withdrawal.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

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