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Vasopressin Receptor

Vasopressin receptor antagonists and agonists target the receptors for the hormone arginine vasopressin. The V1a receptor mediates vascular contraction, the V1b receptor controls pituitary corticotropin release, and the V2 receptor regulates water reabsorption in the kidney. Cloning of the rat V1a receptor and of the V2 receptor was reported in 1992, and V2 receptor defects were linked to nephrogenic diabetes insipidus. Tolvaptan and mozavaptan are nonpeptide V2 receptor antagonists, while conivaptan hydrochloride blocks both V1a and V2 receptors. OPC21268 is a V1 antagonist, and Vasopressin antagonist 1867 targets the V1b receptor. Peptide agonists such as desmopressin and terlipressin serve as tools for receptor activation studies.

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  • DM-4111
    Cat. No.
    A64051
    CAS No.
    926035-36-1

    DM-4111

    DM-4111 is a potent inhibitor of the vasopressin V2 receptor, playing a significant role in modulating water reabsorption in the renal tubules. By inhibiting this receptor, DM-4111 facilitates the excretion of electrolyte-free water, making it valuable in studies related to fluid management in various physiological and pathological states. Its application extends to research focused on cardiovascular diseases, where regulation of fluid balance is critical.

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