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Bradykinin Receptor

Bradykinin receptor agonists and antagonists act on B1 and B2, two G protein-coupled kinin receptors. Kinin peptides such as bradykinin are released from kininogens by kallikreins and regulate vascular tone, permeability and pain signaling. The B2 receptor is expressed constitutively in many tissues, and the human receptor was cloned in 1992. The B1 receptor, cloned in 1994, is induced by tissue injury and inflammation and prefers des-Arg kinin metabolites. A 2005 International Union of Pharmacology (IUPHAR) review set out this classification of the kinin receptor family. Icatibant is a peptide B2 antagonist, and FR167344 free base is a nonpeptide B2 antagonist. R715 and SSR240612 block the B1 receptor, while Lys-[Des-Arg9]Bradykinin TFA acts as a B1 agonist.

1 Item

  • NPC 573
    Cat. No.
    A96819
    CAS No.
    119953-19-4

    NPC 573

    NPC 573 is a bradykinin analog that functions primarily as a selective inhibitor of uterine contraction. This compound is valuable for research into the mechanisms of smooth muscle regulation and may have applications in studies related to reproduction and pain modulation. By understanding its effects on uterine activity, researchers can explore potential therapeutic interventions for related conditions.

    In stock View Details
    25 mg
    $1,275.00
    All 1 sizes

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