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G Protein

G protein reagents here range from guanine nucleotides to ligands for orphan G protein-coupled receptors. Heterotrimeric G proteins consist of a Gα subunit, which binds guanine nucleotides, and a tightly associated Gβγ dimer. An activated G protein-coupled receptor (GPCR) exchanges guanosine diphosphate (GDP) for guanosine triphosphate (GTP) on Gα, which then separates from Gβγ. Guanosine 5'-triphosphate trisodium salt is listed as a G protein activator, but most other compounds act on less studied receptors. G15 blocks the G protein-coupled estrogen receptor (GPER, also called GPR30), and CID16020046 antagonizes G protein-coupled receptor 55 (GPR55). Kynurenic acid, an endogenous tryptophan metabolite, is listed as a GPR35 agonist. GTPase-accelerating proteins that end the signal are covered in RGS Protein.

1 Item

  • PH-064 (tetra(hydrochloride))
    Cat. No.
    A25705
    CAS No.
    2489449-03-6

    PH-064 (tetra(hydrochloride))

    Synonyms: BIM-46187 tetrahydrochloride

    PH-064 tetrahydrochloride is a potent inhibitor of the heterotrimeric G-protein complex. It effectively inhibits serotonin transporter (SERT) activity and reduces shear stress-induced Akt phosphorylation, showcasing significant anti-hyperalgesic properties. This compound is valuable for research in pain models, including inflammatory and neuropathic pain, as well as in studies related to G protein-coupled receptor-dependent tumorigenesis and inflammatory lung injury.

    In stock View Details
    1 mg
    $120.00
    2 mg
    $160.00
    All 8 sizes

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