CDK | Adooq Bioscience

Cat. No.: A13547

CAS No.: 920113-03-7

P276-00

Synonyms: P276

P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3

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1 mg

$35.00

5 mg

$85.00

All 7 sizes

Cat. No.: A13550

CAS No.: 492445-28-0

PHA690509

Synonyms: NOP-1A

PHA-690509 is a ATP-competitive CDK inhibitor.

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2 mg

$300.00

5 mg

$500.00

All 6 sizes

Cat. No.: A13559

CAS No.: 1429515-59-2

FN-1501

FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity.

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1 mg

$75.00

5 mg

$190.00

All 7 sizes

Cat. No.: A14025

CAS No.: 1401033-86-0

AMG-925

AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor.

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1 mg

$25.00

2 mg

$35.00

All 7 sizes

Cat. No.: A14136

CAS No.: 220036-08-8

NU6027

NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.

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5 mg

$30.00

10 mg

$55.00

All 7 sizes

Cat. No.: A14273

CAS No.: 1073485-20-7

LDC000067

Synonyms: LDC067

LDC000067 is a highly selective CDK9 inhibitor .

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2 mg

$30.00

5 mg

$40.00

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Cat. No.: A14318

CAS No.: 377090-84-1

SU9516

SU9516 is a potent, selective cdk2 inhibitor. It inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest.

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1 mg

$25.00

2 mg

$35.00

All 9 sizes

Cat. No.: A14392

CAS No.: 1000023-04-0

Voruciclib

Voruciclib is a flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity.

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1 mg

$140.00

5 mg

$280.00

All 6 sizes

Cat. No.: A14414

CAS No.: 883561-04-4

CA-224

CA-224 is potent CDK4 inhibitor,is also a nonplanar analogue of fascaplysin that specifically inhibits Cdk4-cyclin D1 in vitro.

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2 mg

$150.00

5 mg

$310.00

All 6 sizes

Cat. No.: A15005

CAS No.: 1431697-85-6

AT7519 trifluoroacetate

AT7519 trifluoroacetate is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM, less potent to CDK3 and little active to CDK7.

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2 mg

$50.00

5 mg

$55.00

All 6 sizes

Cat. No.: A15039

CAS No.: 1263369-28-3

CDK9 inhibitor 2

CDK9-IN-2 is a novel cyclin-dependent kinase 9(CDK9) inhibitor.

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1 mg

$75.00

5 mg

$190.00

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Cat. No.: A15054

CAS No.: 199986-75-9

CVT-313

Synonyms: NG 26

CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 215 uM for Cdk4/D1).

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1 mg

$30.00

2 mg

$45.00

All 9 sizes

Cat. No.: A15196

CAS No.: 902156-99-4

NVP-LCQ195

Synonyms: LCQ-195; AT-9311

NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.

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1 mg

$35.00

5 mg

$90.00

All 8 sizes

Cat. No.: A15485

CAS No.: 837364-57-5

AG-024322

AG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models.

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1 mg

$220.00

2 mg

$360.00

All 6 sizes

Cat. No.: A15509

CAS No.: 211555-08-7

WHI-P180

Synonyms: Janex 3

WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.

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1 mg

$35.00

2 mg

$65.00

All 8 sizes

Cat. No.: A15517

CAS No.: 212844-53-6

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.

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5 mg

$25.00

10 mg

$40.00

All 6 sizes

Cat. No.: A15767

CAS No.: 161058-83-9

NU2058

NU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1.

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5 mg

$25.00

10 mg

$40.00

All 7 sizes

Cat. No.: A15823

CAS No.: 1619903-54-6

LY2857785

LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.

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1 mg

$40.00

2 mg

$60.00

All 8 sizes

Cat. No.: A15889

CAS No.: 853299-07-7

K03861

K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.

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5 mg

$35.00

10 mg

$65.00

All 7 sizes

Cat. No.: A15942

CAS No.: 189232-42-6

Bohemine

Bohemine is a potent and selective, cell-permeable, cyclin-dependent kinase (CDK) inhibitor with IC50 = 1 ,M.

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5 mg

$20.00

10 mg

$35.00

All 7 sizes

Cat. No.: A16216

CAS No.: 1661839-45-7

CCT251545

CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.

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1 mg

$30.00

5 mg

$75.00

All 6 sizes

Cat. No.: A16325

CAS No.: 1627696-51-8

LY-3177833

LY-3177833 is a potent and selective inhibitor of CDC7 (Cell Division Cycle 7-related Protein Kinase).

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1 mg

$25.00

5 mg

$70.00

All 8 sizes

Cat. No.: A16808

CAS No.: 2097938-73-1

MBQ-167

MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.

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1 mg

$25.00

2 mg

$35.00

All 8 sizes

Cat. No.: A16903

CAS No.: 1805789-54-1

ICEC0942 HCl

Synonyms: CT7001

ICEC0942, also known as CT7001, is an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment. It selectively inhibits CDK7, with an IC50 of 40nM; IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher.

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1 mg

$110.00