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LY2857785

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CDK9 inhibitor

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Catalog No. A15823

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LY2857785 5mg A15823-5

Regular Price: €285.00

Special Price: €256.50

LY2857785 10mg A15823-10

Regular Price: €522.50

Special Price: €470.25

LY2857785 25mg A15823-25

Regular Price: €1,140.00

Special Price: €1,026.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.

LY2857785

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Chemical Information

Catalog Num A15823
Actions Inhibitor
M. Wt 448.6
Formula C26H36N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1619903-54-6
Synonyms LY-2857785, LY 2857785
SMILES code CC(C)C1=C2C=C(C=CC2=NN1C)C3=NC(=NC=C3)NC4CCC(CC4)NC5CCOCC5
Chemical Name (1r,4r)-N1-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-N4-(tetrahydro-2H-pyran-4-yl)cyclohexane-1,4-diamine

Biological Activity

Description
 LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.29 mL 111.46 mL 222.92mL
0.5 mM 4.46 mL 22.29 mL 44.58 mL
1 mM 2.23 mL 11.15 mL 22.29 mL
5 mM 0.45 mL 2.23 mL 4.46 mL

*The above data is based on the productmolecular weight 448.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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