LY2857785

Catalog No.: A15823

CDK9 inhibitor

LY2857785

LY2857785 Chemical Structure

CAS NO. 1619903-54-6

LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.

Availability: In stock

Package Price Qty
5 mg
$240.00
10 mg
$390.00
25 mg
$800.00
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Biological Activity

LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.
In vitro DMSO 22 mg/mL (49.04 mM)
Water Insoluble
Ethanol 40 mg/mL (89.16 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.29 mL 111.46 mL 222.92 mL
0.5 mM 4.46 mL 22.29 mL 44.58 mL
1 mM 2.23 mL 11.15 mL 22.29 mL
5 mM 0.45 mL 2.23 mL 4.46 mL

*The above data is based on the productmolecular weight 448.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15823
Actions Inhibitor
CAS No. 1619903-54-6
Formula C26H36N6O
M. Wt 448.6
Purity >98%
Synonyms LY-2857785, LY 2857785
SMILES CC(C)C1=C2C=C(C=CC2=NN1C)C3=NC(=NC=C3)NC4CCC(CC4)NC5CCOCC5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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