Catalog No.: A14025

Dual FLT3/CDK4 inhibitor


AMG-925 Chemical Structure

CAS NO. 1401033-86-0

AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor.

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25 mg
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Biological Activity

AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor.
1 nM3 nM2.22 μM
In vitro (25°C) DMSO 0.01 mg/mL (0.02 mM)
Water <1 mg/mL
Ethanol Insoluble
In vivo 2% hydroxypropyl methylcellulose+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.03 mL 212.07 mL
0.5 mM 4.24 mL 21.21 mL 42.41 mL
1 mM 2.12 mL 10.6 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14025
Actions Inhibitor
CAS No. 1401033-86-0
Formula C26H29N7O2
M. Wt 471.55
Purity >98%
Synonyms AMG925, AMG 925

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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