AMG-925

Name: AMG-925
Brand: Adooq Bioscience
SKU: A14025
Rating: 100 (268 reviews)

Catalog No.: A14025

Dual FLT3/CDK4 inhibitor

AMG-925 Chemical Structure

CAS NO. 1401033-86-0

AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor.

Availability: In stock

Package	Price	Qty
5 mg	$77.00
10 mg	$120.00
25 mg	$231.00
Custom Size	Get quote

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Biological Activity

AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor.

Targets

FLT3	CDK4	CDK1
1 nM	3 nM	2.22 μM

Solubility *

In vitro (25°C)	DMSO	0.01 mg/mL (0.02 mM)
	Water	<1 mg/mL
	Ethanol	Insoluble
In vivo	2% hydroxypropyl methylcellulose+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.21 mL	106.03 mL	212.07 mL
0.5 mM	4.24 mL	21.21 mL	42.41 mL
1 mM	2.12 mL	10.6 mL	21.21 mL
5 mM	0.42 mL	2.12 mL	4.24 mL

*The above data is based on the productmolecular weight 471.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A14025
Actions	Inhibitor
CAS No.	1401033-86-0
Formula	C26H29N7O2
M. Wt	471.55
Purity	>98%
Synonyms	AMG925, AMG 925
SMILES	CC1CCC(CC1)N2C3=C(C=CN=C3)C4=CN=C(N=C42)NC5=NC6=C(CN(CC6)C(=O)CO)C=C5
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.