DGAT

Cat. No.

A11199

CAS No.

959122-11-3

A 922500

Synonyms: DGAT-1 Inhibitor 4a

A 922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively).

Cat. No.

A15919

CAS No.

6754-58-1

Xanthohumol

Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects.

Cat. No.

A11386

CAS No.

701232-20-4

T863

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.

Cat. No.

A11526

CAS No.

1109276-89-2

PF-04620110

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

Cat. No.

A12475

CAS No.

956136-95-1

Pradigastat

Synonyms: LCQ-908

Pradigastat (LCQ-908) is a diacylglycerol acyltransferase 1 (DGAT1) inhibitor.

Cat. No.

A12608

CAS No.

1469284-78-3

PF-06424439

PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM.

Cat. No.

A13208

CAS No.

892489-52-0

AZD3988

AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively.

Cat. No.

A14984

CAS No.

1031336-60-3

ABT-046

Synonyms: DGAT-1 inhibitor; ABT 046,ABT046

ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50= 8 nM).

Cat. No.

A15012

CAS No.

1166827-44-6

AZD7687

AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1).

Cat. No.

A15067

CAS No.

942999-61-3

DGAT-1 inhibitor 2

DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1;antiobesity agents.

Cat. No.

A20060

CAS No.

2219321-25-0

GSK2973980A

GSK2973980A is a potent and selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 3 nM.

Cat. No.

A20315

CAS No.

1610800-25-3

Diacylglycerol acyltransferase inhibitor-1

Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol acyltransferase (DGAT1) inhibitor.

Cat. No.

A21343

CAS No.

1469284-79-4

PF-06424439 methanesulfonate

Synonyms: PF06424439

PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM.

Cat. No.

A21524

CAS No.

1449779-49-0

DGAT1-IN-1

DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).

Cat. No.

A49372

CAS No.

120693-53-0

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone is a diacylglycerol acyltransferase (DGAT) inhibitor, demonstrating an IC50 of 20.1 μM. Additionally, it acts as an angiotensin II receptor blocker with an IC50 of 34.1 μM. This compound exhibits significant anti-Helicobacter pylori activity, with a minimum inhibitory concentration (MIC) of 10 μg/mL, making it valuable for studies investigating lipid metabolism and bacterial infections.

Cat. No.

A52856

CAS No.

1522004-70-1

Aphadilactone C

Aphadilactone C is a selective inhibitor of diacylglycerol O-acyltransferase 1 (DGAT-1), exhibiting an IC50 of 0.46 μM. In addition to its DGAT-1 inhibition, Aphadilactone C demonstrates notable antimalarial properties with an IC50 value of 170 nM. This compound is valuable for research related to lipid metabolism and malaria treatment studies.

Cat. No.

A65955

CAS No.

956136-98-4

Pradigastat sodium

Synonyms: LCQ 908 sodium

Pradigastat sodium is a selective inhibitor of diacylglyceryl acyltransferase 1 (DGAT1), demonstrating an IC50 value of 0.157 µM. This compound is utilized in research focused on diseases related to abnormal triglyceride metabolism, exhibiting anti-obesity and anti-diabetic properties. Additionally, Pradigastat impacts several transporters, including BCRP, OATP1B1, OATP1B3, and OAT3, with respective IC50 values of 5 µM, 1.66 µM, 3.34 µM, and 0.973 µM. Furthermore, it possesses antiviral activity, effectively inhibiting hepatitis C virus replication in vitro.

Cat. No.

A69221

CAS No.

3037141-61-7

DGAT2-IN-3

DGAT2-IN-3 is a potent inhibitor of diacylglycerol O-acyltransferase 2 (DGAT2), exhibiting an IC50 of 0.4 nM. This compound is valuable for investigating metabolic disorders such as steatohepatitis, diabetes, and cardiovascular diseases, providing insights into the role of DGAT2 in lipid metabolism and associated pathologies.

Cat. No.

A69226

CAS No.

1414797-35-5

(Rac)-GSK2973980A

(Rac)-GSK2973980A is a potent diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 1.8 nM for human DGAT1. This compound is useful for investigating the role of DGAT1 in lipid metabolism and is applicable in obesity and obesity-related disease research. Its selective inhibition of DGAT1 provides valuable insights into therapeutic targets for metabolic disorders.

Cat. No.

A69227

CAS No.

1809064-23-0

PF-06427878

PF-06427878 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2), demonstrating IC50 values of 99 nM and 202 nM for human and rat DGAT2, respectively. The compound exhibits over 470-fold selectivity for DGAT2 compared to DGAT1 and monoacylglycerol acyltransferases (MGAT1, MGAT2, MGAT3). PF-06427878 is effective in improving liver steatosis and function, making it a valuable reagent for research into nonalcoholic fatty liver disease and related metabolic disorders.

Cat. No.

A69236

CAS No.

2304711-30-4

Obeversen

Synonyms: ION-769357

Obeversen is an antisense oligonucleotide that specifically inhibits diacylglycerol acyltransferase 2 (DGAT-2). This inhibition plays a crucial role in disrupting lipid metabolism and has been implicated in the research of nonalcoholic fatty liver disease. Obeversen serves as a valuable tool for studying the molecular mechanisms underlying lipid dysregulation and offers potential insights into therapeutic targets for metabolic disorders.

Cat. No.

A69240

CAS No.

2186700-48-9

Diacylglycerol acyltransferase inhibitor-2

Diacylglycerol acyltransferase inhibitor-2 is a specific inhibitor of Diacylglycerol Acyl Transferase 2 (DGAT2) with an IC50 value of 3.7 nM. This compound is essential for studying lipid metabolism and may have applications in research related to obesity and metabolic disorders. Its ability to selectively inhibit DGAT2 makes it a valuable tool for elucidating the role of this enzyme in various biological processes.

Cat. No.

A69241

CAS No.

2304711-35-9

Obeversen sodium

Synonyms: ION-769357 sodium

Obeversen sodium is an antisense oligonucleotide that selectively inhibits Diacylglycerol acyltransferase 2 (DGAT-2) synthesis. This inhibition plays a critical role in modulating lipid metabolism, making it a valuable tool for studying nonalcoholic fatty liver disease and related metabolic disorders. Researchers can utilize Obeversen sodium to explore the pathways associated with lipid accumulation and investigate potential therapeutic targets in hepatic diseases.

Cat. No.

A69249

CAS No.

791593-56-1

BAY 74-4113

BAY 74-4113 is a potent inhibitor of diacylglycerol O-acyltransferase 1 (DGAT1), with an IC50 value of 72 nM. Its primary biological activity involves the modulation of lipid metabolism, making it a useful tool in obesity research. BAY 74-4113 may aid in elucidating the role of DGAT1 in metabolic disorders and the development of therapeutic strategies targeting fat accumulation.

Cat. No.

A69261

CAS No.

701232-94-2

JTT-553

JTT-553 is a potent inhibitor of diacylglycerol O-acyltransferase 1 (DGAT1) with an IC50 value of 2.38 nM. This compound has demonstrated efficacy in lowering plasma levels of glucose, insulin, non-esterified fatty acids, total cholesterol, and hepatic triglycerides. Additionally, JTT-553 enhances insulin-dependent glucose uptake and ameliorates glucose intolerance in adipose tissue of DIO mice, while also modulating TNF-α and GLUT4 mRNA levels in KK-Ay mice. This reagent is valuable for research focused on obesity and type 2 diabetes mellitus (T2DM).