Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
N-(Boc-PEG2)-N-bis(PEG3-azide) is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. It is valuable for researchers focusing on targeted protein degradation and expanding the applications of PROTAC technology. -
PROTAC Linker
m-PEG9-azide serves as a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functionality that enables it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkynyl compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it a versatile tool for chemical biology applications, particularly in targeted protein degradation research. -
PROTAC linker
Azido-PEG2-hydrazide-Boc is a PEG-based linker designed for use in the synthesis of PROTACs. Functioning as a click chemistry reagent, it features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with compounds containing DBCO or BCN groups. This linker is essential for developing targeted protein degradation strategies and enhances the versatility of bioconjugation in chemical biology research. -
PROTAC linker
N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 functions as a PEG-based PROTAC linker, facilitating the synthesis of heterobifunctional protein-targeting chimeras. This compound features an azide group, enabling its use in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it suitable for advanced applications in chemical biology and targeted protein degradation research. -
PROTAC Linker
Amino-PEG4-hydrazide-Boc is a PEG-based linker specifically designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a hydrazide functional group, facilitating the conjugation of large biomolecules to induce targeted protein degradation. Its unique structure enhances solubility and stability, making it suitable for a variety of applications in chemical biology and drug discovery. -
PROTAC linker
Methyltetrazine-amido-PEG7-azide is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is suitable for strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, making it a versatile tool in chemical biology and drug development. -
PROTAC Linker
Fmoc-N-amido-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, functioning primarily through click chemistry. This compound features an azide group that allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool in chemical biology research and therapeutic development. -
PROTAC linker
Boc-Aminooxy-PEG1-azide is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds. This reagent is pivotal for studies in targeted protein degradation, providing a versatile tool for advancing research in cell biology and therapeutic development. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. Functioning as a click chemistry reagent, it features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it valuable for the development of targeted protein degradation strategies in chemical biology research. -
PROTAC linker
m-PEG10-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring an azide functional group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, as well as those with DBCO or BCN groups. This versatile reagent is essential for the assembly of complex bioconjugates, facilitating targeted protein degradation research and advancing drug discovery applications. -
PROTAC Linker
Azide-PEG3-Sulfone-PEG3-azide is a PEG-based linker designed for use in PROTAC synthesis, facilitating the creation of targeted protein degraders. This compound features an azide functional group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups, making it versatile for various bioconjugation applications in chemical research. -
PROTAC Linkers
Fmoc-N-amido-PEG5-azide is a PEG-based PROTAC linker designed for use in the synthesis of PROTAC compounds. This reagent features an azide moiety that enables it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified entities, making it a versatile tool for bioconjugation and chemical biology applications. -
PROTAC linker
N-Methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3 is a PEG-based PROTAC linker designed for the assembly of PROTAC molecules. Its azide functionality allows for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-bearing compounds. Additionally, it is suitable for strain-promoted azide-alkyne cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononynes (BCN), facilitating precise biomolecular conjugation. This reagent is pivotal for advancing drug development and targeted protein degradation research. -
PROTAC Linker
Fluorescein-thiourea-PEG2-azide is a PEG-based linker designed for use in the synthesis of PROTACs, functioning primarily through click chemistry. This reagent contains an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can perform strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it a versatile tool for bioconjugation applications in chemical biology and drug development. -
PROTAC Linker
Azido-PEG3-S-PEG3-azide is a PEG-based linker designed for targeted protein degradation applications via PROTAC technology. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-bearing compounds, making it a versatile tool for bioconjugation and drug development research. -
PROTAC Linker
Ald-C2-PEG4-azide serves as a PEG-based PROTAC linker, facilitating the synthesis of PROTAC compounds. This compound features an azide functional group enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it a versatile tool for bioconjugation and targeted protein degradation studies. -
PROTAC Linker
Trityl-PEG8-azide is a PEG-based linker specifically designed for PROTAC synthesis, facilitating targeted protein degradation. This compound features an azide group, enabling its use in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-functionalized molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool in chemical biology and drug development research. -
PROTAC Linker
Benzyl-PEG6-azide is a polyethylene glycol (PEG)-based reagent designed as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group which enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclo[6.1.0]non-4-yne (BCN) derivatives, making it a versatile tool in chemical biology for targeted protein degradation studies. -
PROTAC linker
N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 functions as a PEG-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is equipped with an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for chemical biology applications in targeted protein degradation research. -
PROTAC Linker
m-PEG3-Sulfone-PEG3-azide is a PEG-based linker specifically designed for PROTAC synthesis. Featuring an azide functional group, this compound enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, facilitating the development of innovative targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
m-PEG4-Hydrazide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its unique hydrazide functionality facilitates the conjugation of target proteins with E3 ubiquitin ligases, thereby promoting targeted protein degradation. This compound is an essential tool for researchers exploring targeted therapy and studying protein regulation mechanisms. -
PROTAC linker
N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This molecule features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalities. Its efficient coupling capabilities make it valuable for advancing research in targeted protein degradation and the development of therapeutic modalities. -
PROTAC Linkers
Boc-NH-PEG4-azide is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTACs. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Boc-NH-PEG4-azide can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with donors like DBCO or BCN. Its versatile reactivity makes it a valuable tool in chemical biology and drug discovery research applications. -
PROTAC Linkers
N-(Boc-PEG3)-N-bis(PEG3-azide) serves as a polyethylene glycol (PEG)-based linker for PROTAC (proteolysis targeting chimeras) synthesis, facilitating the development of targeted protein degradation strategies. This compound contains an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with alkyne-containing partners, such as DBCO and BCN groups. Its versatile reactivity makes it valuable in chemical biology research for constructing novel PROTACs. -
PROTAC Linkers
m-PEG16-azide is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing compounds. Additionally, m-PEG16-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) tagged molecules, making it a valuable tool for bioconjugation and targeted protein degradation studies. Its versatile reactivity enhances the development of novel therapeutic strategies in chemical biology and drug discovery. -
PROTAC linker
m-PEG5-azide is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing molecules. This versatile reagent is essential for advancing research in targeted protein degradation and related fields. -
Metal-organic Framework
1,4-Benzenedicarboxylic acid, 2,3-dihydroxy-, 1,4-dihydrazide, also known as 2,3-Dihydroxyterephthalohydrazide, serves as a key building block in the synthesis of metal-organic frameworks (MOFs). This compound exhibits significant potential in applications related to gas storage, catalysis, and separation technologies. Its dual functional groups enhance coordination with metal ions, thereby facilitating the formation of robust MOF structures suitable for various research applications in material science and chemistry. -
Stable Isotope
Acetohydrazide-d3 is a deuterium-labeled derivative of Acetohydrazide, functioning as a stable isotope. This compound is utilized in organic synthesis and can undergo catalytic hydrogenation to yield N′-methyl acethydrazide (MAH). It serves as a valuable tool for researchers studying reaction mechanisms and developing novel chemical pathways in organic chemistry. -
Stable Isotope
Chlorothiazide-13C,15N2 is the stable isotope-labeled form of Chlorothiazide, incorporating 13C and 15N isotopes. Chlorothiazide functions as an orally active diuretic and anti-hypertensive agent, primarily targeting renal sodium-coupled transport processes. This reagent is beneficial for research applications involving metabolic studies, pharmacokinetic assessments, and isotopic tracing in physiological experiments. -
Biochemical Assay Reagent
3-Maleimidylpropanoyl hydrazide hydrochloride is a biochemical assay reagent that primarily functions as a crosslinking agent. It facilitates the formation of stable conjugates between thiol-containing biomolecules, making it valuable for labeling and detecting proteins in various assays. This reagent is widely used in life sciences research for studying protein interactions and developing bioconjugates for drug delivery applications. -
Biochemical Assay Reagent
Bromoacetamido-PEG2-azide is a heterobifunctional polyethylene glycol (PEG) linker that features a reactive bromoacetamido group and a terminal azide moiety. The bromoacetamido component facilitates nucleophilic substitution, enabling covalent attachment to various nucleophiles. The azide group is compatible with alkyne, BCN, and DBCO through Click Chemistry, making this reagent an essential tool for biochemical assays and bioconjugation applications in chemical biology and drug development. -
Trinitride
(Rac)-Azide-deoxy-ascomycin-O-ethylene is a nitrogen-containing derivative of the macrolide immunosuppressant ascomycin. It functions as a trinitride, exhibiting potential biological activity related to immunosuppression. This compound is primarily utilized in pharmacological research, particularly in the study of immunological responses and the development of novel therapeutic agents targeting immune-related conditions. -
Drug Intermediate
Cyanoacetohydrazide serves as a pharmaceutical intermediate, primarily utilized in the synthesis of acylhydrazide hydrazone derivatives. These derivatives have demonstrated notable antibacterial and anti-tumor activities, making cyanoacetohydrazide a valuable compound in drug development and medicinal chemistry research. Its versatile applications in synthesizing bioactive compounds contribute significantly to advancing therapeutic strategies. -
Drug Intermediate
2-Pyridinecarbohydrazide is a versatile building block commonly employed as a drug intermediate in synthetic processes. Its structure allows for diverse modifications, facilitating the development of biologically active compounds. Applications include the synthesis of pharmaceuticals and agrochemicals, making it an essential reagent in chemical research and development. -
Synthetic Intermediate
Nicotinoyl azide serves as a versatile synthetic intermediate, notable for its ability to form high-energy intermediates that generate C-8 adducts with adenosine and guanosine. The compound contains an azide functional group and is amenable to copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in ring strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds featuring DBCO or BCN functionalities, making it valuable for diverse applications in chemical biology and medicinal chemistry. -
Biochemical Assay Reagents
β-GalNAc-PEG4-Azide is a specific ligand for the asialoglycoprotein receptor, linked via a PEG4 spacer and featuring an azide functionality. This compound enables efficient click chemistry applications, facilitating conjugation with various biomolecules for biochemical assays. Its design enhances targeted delivery and is particularly useful in the study of glycoprotein interactions and receptor-mediated endocytosis. -
Biochemical Assay Reagent
Tetra-(amido-PEG10-azide) is a branched polyethylene glycol (PEG) reagent featuring four azide groups at its termini, facilitating PEGylation through Click Chemistry. Its unique structure enhances solubility and stability of biomolecules, making it ideal for biochemical assays and labeling applications. The incorporation of this reagent can significantly improve the pharmacokinetics and bioavailability of therapeutic proteins and peptides in research settings. -
Biochemical Assay Reagent
Octyl azide (1-Azidooctane) is a biochemical assay reagent characterized by an azide functional group and an eight-carbon alkyl chain. The azide group is capable of undergoing Click Chemistry reactions with alkynes, BCN, and DBCO, facilitating the formation of stable triazole linkages. This compound serves as a valuable tool in bioconjugation applications, enabling precise labeling and functionalization in various biochemical studies. -
Biochemical Assay Reagent
N-(acid-PEG10)-N-bis(PEG10-azide) is a versatile PEG reagent featuring a terminal carboxylic acid and dual azide groups. The hydrophilic PEG spacer enhances solubility in aqueous environments, facilitating its use in biochemical assays. Through Click Chemistry, the azide groups can efficiently react with alkynes, BCN, and DBCO to form stable triazole linkages. Additionally, the terminal carboxylic acid can conjugate with primary amines in the presence of coupling agents such as EDC or HATU to create stable amide bonds, making it suitable for various bioconjugation applications. -
PEG Linker
Azido-PEG8-hydrazide-Boc is a PEG linker featuring an azide moiety and a Boc-protected hydrazide. This compound serves as a versatile reagent for click chemistry applications, specifically undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. It is ideal for bioconjugation, enabling the formation of stable conjugates in various biological research applications. -
Biochemical Assay Reagent
Iodoacetamido-PEG6-azide is a biochemical assay reagent featuring a hydrophilic PEG linker with an azide group and a terminal iodoacetamido moiety. The azide moiety can undergo click chemistry reactions with alkynes, BCN, or DBCO to form stable triazole linkages. The iodoacetamido group facilitates covalent binding to thiol groups in cysteine residues, effectively preventing the formation of disulfide bonds in proteins. This compound is ideal for applications in protein labeling, modification, and tracking in biochemical studies. -
Biochemical Assay Reagent
AZD-PEG2-azide is a biochemical assay reagent featuring an azide functional group appropriate for bioconjugation applications. Its primary mechanism involves reacting with alkyne-containing partners through the click chemistry reaction, facilitating the creation of stable linkages. This reagent is ideal for various life science research applications, including the development of drug delivery systems and probing biological interactions. -
Biochemical Assay Reagent
Azide-PEG8-Tos is a PEG-based linker characterized by the presence of an azide and a tosylate group. The tosylate functions as an effective leaving group, facilitating displacement reactions with nucleophiles, while the azide serves as a component for click chemistry, allowing for selective reactions with terminal alkynes or strained cyclooctynes. This reagent is valuable in biochemical assays and applications requiring precise bioconjugation techniques. -
Biochemical Assay Reagent
Azido-PEG19-azide is a versatile click chemistry reagent characterized by two terminal azide groups. It facilitates efficient conjugation with alkynes, BCN, and DBCO through azide-alkyne cycloaddition reactions. This reagent is widely utilized in biochemical assays and polymer synthesis, enabling the labeling and modification of biomolecules for various research applications. -
Biochemical Assay Reagent
(Acid-PEG10)-Tri-(Azide-PEG10-ethoxymethyl)-methane is a versatile biochemical assay reagent that facilitates Click Chemistry reactions with propargyl, BCN, or DBCO reagents. The carboxylic acid group exhibits reactivity towards primary amino groups when coupled with EDC or HATU, enabling efficient bioconjugation. This reagent is ideal for applications in developing bioconjugates, analyzing protein interactions, and enhancing labeling strategies in biochemical assays. -
Biochemical Assay Reagent
t-Boc-aminooxy-pentane-azide is a versatile linker designed for biochemical assays, featuring an azide group and a Boc-protected amino group. The azide moiety enables selective reactions with alkynes, BCN, and DBCO through Click Chemistry, facilitating the formation of stable triazole linkages. Upon mild acidic deprotection, the Boc group is removed, yielding a free amine for further applications in bioconjugation and peptide synthesis. This compound is ideal for use in various chemical biology studies and assay development. -
Biochemical Assay Reagent
4-Azide-TFP-Amide-SS-Sulfo-NHS is a biochemical assay reagent featuring an aryl azide, a cleavable disulfide bond, and an NHS ester. The aryl azide facilitates photo-activation using UV light (250 to 350 nm) for efficient conjugation with biomolecules, while the NHS ester enables targeted coupling with amines. The inclusion of a stabilizing fluorine within the structure aids in the stabilization of the free radical intermediate, and the disulfide bond can be cleaved under reducing conditions, providing versatility in biochemical applications. -
Biochemical Assay Reagent
C18-PEG4-Azide is a hybrid linker that combines a hydrophobic C18 fatty acid chain with a hydrophilic PEG4 spacer and an azide functional group. The azide moiety engages in efficient click chemistry with terminal alkynes or strained cyclooctynes, such as DBCO or BCN. This compound is essential for applications in biochemical assays, facilitating the conjugation of biomolecules and the development of complex molecular probes for various research applications. -
Biochemical Assay Reagents
2,3,4,6-Tetra-O-acetyl-β-D-mannopyranosyl azide is a chemical compound that serves as a valuable reagent in biochemical assays within glycobiology research. It functions as a glycosyl donor, facilitating the exploration of carbohydrate-protein interactions and the synthesis of oligosaccharides. This compound aids in the development of glycomimetics and other glycan-based applications, contributing to advancements in carbohydrate chemistry and glycan biology. -
Biochemical Assay Reagent
Tri(Azide-PEG10-NHCO-ethyloxyethyl)amine is a branched polyethylene glycol (PEG) linker featuring three terminal azide moieties. This compound facilitates PEGylation through efficient Click Chemistry, making it valuable for various biochemical assay applications. Its unique structure enhances solubility and biocompatibility, supporting the development of diverse bioconjugates in chemical biology and drug formulation studies.
