AChE

Cat. No.

A78675

CAS No.

688360-06-7

Xanthohumol I

Xanthohumol I is a chalcone derivative of Xanthohumol, known for its role as a Cholinesterase (ChE) inhibitor. It effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 71.34 μM and 32.67 μM, respectively. Additionally, its hydroxy derivative, 3-hydroxy-xanthohumol, also demonstrates inhibitory effects on AChE and BChE, with IC50 values of 51.25 μM and 63.07 μM. This compound is valuable for research in neurodegenerative diseases and related biochemical pathways.

Cat. No.

A78676

CAS No.

1428439-79-5

BChE-IN-20

BChE-IN-20 is a potent and selective inhibitor of butyrylcholinesterase (BChE), demonstrating IC50 values of 105 nM for equine BChE and 2.3 nM for human BChE. Additionally, it inhibits P-glycoprotein with an IC50 of 0.27 μM. This compound serves as a valuable template for the design and development of BChE-selective ligands relevant to pharmacological research, including inhibitors and fluorogenic probes.

Cat. No.

A78677

CAS No.

145701-19-5

Blestrin D

Blestrin D is a potent mixed-type inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 value of 8.1 μM. Isolated from Bletilla striata, this compound is valuable for investigating the biochemical pathways involved in Alzheimer's disease (AD). Its ability to inhibit BChE makes it an important tool for studying cholinergic dysfunction associated with neurodegenerative conditions.

Cat. No.

A78678

CAS No.

3032264-62-0

AChE-IN-22

AChE-IN-22 is a selective inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), exhibiting IC50 values of 0.88 μM and 10 μM, respectively. This compound interacts with both the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE, making it a valuable tool for studies related to Alzheimer's disease. AChE-IN-22 is suitable for research applications focused on cholinergic system modulation and neurodegenerative disease mechanisms.

Cat. No.

A78680

CAS No.

2763366-33-0

eeAChE-IN-2

eeAChE-IN-2 is a highly potent inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 2 nM. This compound serves as a valuable tool for studying cholinergic signaling and its modulation in various biological systems. Its application extends to research on neurodegenerative disorders and cognitive function, where AChE inhibition plays a critical role.

Cat. No.

A78681

CAS No.

2410992-68-4

AChE/BChE-IN-5

AChE/BChE-IN-5 is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 266 nM and 10.6 nM against human AChE (hAChE) and human BChE (hBChE), respectively. This compound is capable of crossing the blood-brain barrier (BBB), making it significant for research in neurodegenerative diseases and cognitive disorders. It serves as a valuable tool for studying the modulation of cholinergic signaling and the potential therapeutic effects in conditions such as Alzheimer's disease.

Cat. No.

A78682

CAS No.

108815-81-2

Isonaringin

Isonaringin is an acetylcholinesterase (AChE) inhibitor that demonstrates potential anti-Alzheimer's activity. By inhibiting AChE, Isonaringin increases acetylcholine levels in the brain, which may help improve cognitive function in neurodegenerative conditions. This compound is relevant for research applications focused on Alzheimer's disease and other related disorders.

Cat. No.

A78684

CAS No.

132236-18-1

Zifrosilone

Zifrosilone is an orally active acetylcholinesterase (AChE) inhibitor, exhibiting a mean maximum inhibition of 20.9% at a dosage of 10 mg. This compound is useful in the study of neurological disorders, providing a valuable tool for research into conditions related to cholinergic dysfunction. Its selective targeting of AChE makes it an important reagent for investigating therapeutic strategies in neurodegenerative diseases.

Cat. No.

A78685

CAS No.

52022-31-8

Ambenonium dichloride tetrahydrate

Synonyms: WIN 8077 dichloride tetrahydrate

Ambenonium dichloride tetrahydrate is a potent, orally active, reversible inhibitor of acetylcholinesterase (AChE). This compound demonstrates a high affinity for human AChE, with an IC50 value of 0.7 nM, making it valuable for investigations into cholinergic system modulation. Its primary applications include the study of neurodegenerative diseases such as myasthenia gravis and Alzheimer's disease, as well as broader neuropharmacological research.

Cat. No.

A78686

CAS No.

2669070-40-8

BuChE-IN-1

BuChE-IN-1 is a potent inhibitor of butyrylcholinesterase (BuChE), a key enzyme implicated as a biomarker in the progression of Alzheimer’s disease (AD). This compound exhibits low cytotoxicity and demonstrates excellent permeability across the blood-brain barrier (BBB). BuChE-IN-1 is an advantageous tool for investigating the role of BuChE in AD research and exploring therapeutic interventions.

Cat. No.

A78687

CAS No.

6586-37-4

K027

K027 is a potent reactivator of acetylcholinesterase (AChE) inhibited by organophosphates (OP). It effectively restores AChE activity, making it valuable for studying neurodegenerative conditions such as Alzheimer's disease. K027's mechanism and specificity provide a useful tool for investigating therapeutic strategies targeting cholinergic dysfunction.

Cat. No.

A78688

CAS No.

2983723-58-4

hAChE-IN-4

hAChE-IN-4 is a potent inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 0.25 μM, demonstrating effective permeability across the blood-brain barrier. This compound plays a significant role in research related to Alzheimer's disease, where modulation of cholinergic activity is critical. Its use can aid in exploring therapeutic strategies targeting cholinesterase activity in neurodegenerative disorders.

Cat. No.

A78690

CAS No.

2977170-10-6

AChE-IN-26

AChE-IN-26 is an acetylcholinesterase (AChE) inhibitor with a reported IC50 of 0.42 μM. This compound plays a significant role in research related to Alzheimer's disease by inhibiting the breakdown of acetylcholine, thereby enhancing cholinergic transmission. AChE-IN-26 serves as a valuable tool for studying pathophysiological mechanisms associated with neurodegeneration and for evaluating potential therapeutic strategies.

Cat. No.

A78691

CAS No.

92829-71-5

Magnotriol B

Magnotriol B is a potent cholinesterase inhibitor, demonstrating IC50 values of 12.63 nM against acetylcholinesterase (AChE) and 14.5 nM against butyrylcholinesterase (BChE). Additionally, it exhibits notable nitric oxide (NO) inhibitory activity, with an IC50 of 2.02 μM. This compound is applicable in research focused on neurodegenerative disorders and inflammatory diseases, offering potential insights into therapeutic strategies targeting cholinergic dysfunction.

Cat. No.

A78692

CAS No.

59252-87-8

Chikusetsusaponin Ib

Chikusetsusaponin Ib is a potent inhibitor of acetylcholinesterase (AChE), a key enzyme involved in neurotransmission. This compound exhibits significant anti-Alzheimer's disease activity, making it a valuable tool for research focused on neurodegenerative disorders. Its ability to modulate AChE activity can aid in the exploration of therapeutic strategies aimed at enhancing cognitive function and addressing Alzheimer’s pathology.

Cat. No.

A78693

CAS No.

1391826-61-1

Picfeltarraegenin X

Picfeltarraegenin X is a triterpenoid that functions as an acetylcholinesterase (AChE) inhibitor. This compound exhibits notable biological activity by enhancing acetylcholine levels, making it relevant for studies focused on neurodegenerative disorders such as Alzheimer's disease. Picfeltarraegenin X is useful in research applications aimed at understanding cholinergic signaling and developing potential therapeutic strategies targeting cognitive decline.

Cat. No.

A78697

CAS No.

19553-26-5

Cyclopenin ((±)-Isocyclopenine)

Synonyms: (±)-Isocyclopenine

Cyclopenin is a cholinesterase (ChE) inhibitor that effectively modulates acetylcholine levels by preventing its breakdown. This compound exhibits significant biological activity in the study of neurodegenerative diseases and offers potential applications in the examination of cognitive disorders. Researchers can leverage Cyclopenin’s properties for investigations into synaptic transmission and cholinergic signaling pathways.

Cat. No.

A78698

CAS No.

307535-32-6

AChE-IN-98

AChE-IN-98 is a potent acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 value of 7.3 μM for human AChE. As a derivative of coumarin, it demonstrates significant biological activity relevant to the modulation of cholinergic neurotransmission. This compound is primarily utilized in research focused on Alzheimer's disease, providing insights into potential therapeutic strategies targeting cognitive decline.

Cat. No.

A78699

CAS No.

495-59-0

Desoxypeganine

Synonyms: Deoxypeganine; Deoxyvasicine

Desoxypeganine is a potent alkaloid that serves as an inhibitor of cholinesterase (both BChE and AChE) as well as a selective inhibitor of monoamine oxidase A (MAO-A), exhibiting IC50 values of 2, 17, and 2 μM, respectively. This compound is primarily utilized in research related to alcohol abuse, offering valuable insights into the underlying mechanisms of addiction and potential therapeutic approaches. Its dual inhibitory action positions Desoxypeganine as a significant tool in the study of neurochemical pathways involved in substance use disorders.

Cat. No.

A78701

CAS No.

159898-12-1

ω-Hydroxydigitoemodin

ω-Hydroxydigitoemodin is an anthraquinone derivative that functions as an acetylcholinesterase inhibitor. This compound exhibits significant anti-acetylcholinesterase activity and has been identified in the marine fungus Trichoderma harzianum XS-20090075. It is utilized in research exploring neurodegenerative diseases and potential therapeutic approaches targeting cholinergic signaling pathways.

Cat. No.

A78702

CAS No.

2410992-65-1

AChE/BChE-IN-3

AChE/BChE-IN-3 is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 6.08 μM and 0.383 μM against electric eel AChE and equine serum BChE, respectively. This compound demonstrates effective inhibition of cholinesterases, which are important targets in studies related to neurodegenerative diseases and pesticide exposure. AChE/BChE-IN-3 is valuable for research applications focused on understanding cholinergic signaling and developing therapeutic strategies for conditions such as Alzheimer's disease.

Cat. No.

A78703

CAS No.

2937454-22-1

AChE-IN-30

AChE-IN-30 is an acetylcholinesterase (AChE) inhibitor with an IC50 value of 4.4 μM. It exhibits neuroprotective properties by inhibiting H2O2-induced apoptosis through the reduction of intracellular reactive oxygen species (ROS) accumulation. This compound is valuable for research into Alzheimer's disease and related neurodegenerative disorders.

Cat. No.

A78705

CAS No.

219920-81-7

Bisnorcymserine

Synonyms: N1,N8-Bisnorcymserine; (-)-Bisnorcymserine

Bisnorcymserine is a potent inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.228 nM. This compound effectively reduces levels of amyloid-β peptide (Aβ) and has demonstrated therapeutic potential in ameliorating symptoms of Alzheimer's Disease in aged rat models. Bisnorcymserine's ability to penetrate the blood-brain barrier makes it a valuable tool for research in neurodegenerative disorders.

Cat. No.

A78706

CAS No.

136966-86-4

BChE-IN-12

BChE-IN-12 is a non-competitive inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 2.3 μM. Isolated from Bletilla striata, this compound demonstrates significant inhibitory activity that can aid in the investigation of cholinergic dysfunction. BChE-IN-12 is particularly relevant for research applications focused on Alzheimer's disease and other cognitive disorders where BChE modulation may play a therapeutic role.

Cat. No.

A78709

CAS No.

2294963-47-4

AChE/BChE-IN-4

AChE/BChE-IN-4 is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 792 nM for human AChE and 2.2 nM for human BChE. This compound is capable of crossing the blood-brain barrier, making it a valuable tool for research into neurodegenerative diseases such as Alzheimer's. Its selective inhibition profile provides insights into cholinergic system modulation and potential therapeutic applications.