AChE

Cat. No.

A78705

CAS No.

219920-81-7

Bisnorcymserine

Synonyms: N1,N8-Bisnorcymserine; (-)-Bisnorcymserine

Bisnorcymserine is a potent inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.228 nM. This compound effectively reduces levels of amyloid-β peptide (Aβ) and has demonstrated therapeutic potential in ameliorating symptoms of Alzheimer's Disease in aged rat models. Bisnorcymserine's ability to penetrate the blood-brain barrier makes it a valuable tool for research in neurodegenerative disorders.

Cat. No.

A78706

CAS No.

136966-86-4

BChE-IN-12

BChE-IN-12 is a non-competitive inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 2.3 μM. Isolated from Bletilla striata, this compound demonstrates significant inhibitory activity that can aid in the investigation of cholinergic dysfunction. BChE-IN-12 is particularly relevant for research applications focused on Alzheimer's disease and other cognitive disorders where BChE modulation may play a therapeutic role.

Cat. No.

A78707

CAS No.

2058-89-1

MMB-4

MMB-4 is an oxime compound that functions as a reactivator of cholinesterases inhibited by organophosphate exposure, including agents such as Sarin and Soman. It exhibits significant biological activity in restoring the enzymatic function of cholinesterases, thereby countering the toxic effects associated with organophosphate poisoning. This capability makes MMB-4 a valuable tool for research in toxicology and pharmacology, particularly in the study of antidotal therapies for nerve agent exposure.

Cat. No.

A78708

CAS No.

6900-92-1

Lycodoline

Lycodoline is an alkaloid compound known for its inhibition of butyrylcholinesterase (BChE), with an IC50 value of 667 μM. This specific activity makes Lycodoline a valuable tool in studies focused on neurodegenerative diseases where cholinergic signaling is disrupted. Its properties may contribute to research on cognitive enhancement and therapeutic strategies targeting cholinergic pathways.

Cat. No.

A78709

CAS No.

2294963-47-4

AChE/BChE-IN-4

AChE/BChE-IN-4 is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 792 nM for human AChE and 2.2 nM for human BChE. This compound is capable of crossing the blood-brain barrier, making it a valuable tool for research into neurodegenerative diseases such as Alzheimer's. Its selective inhibition profile provides insights into cholinergic system modulation and potential therapeutic applications.

Cat. No.

A78710

CAS No.

126988-60-1

KBR 2822

KBR 2822 is a selective inhibitor of neurological target esterase (NTE) and exhibits inhibitory activity against acetylcholinesterase (AChE). This compound is utilized in research to investigate the mechanisms of neurological damage and the role of NTE in neurotoxicity. While KBR 2822 can exacerbate neurological damage under specific conditions, it does not induce neurological disease when administered alone without direct neurotoxic effects or biochemical alteration.

Cat. No.

A78711

CAS No.

2919335-82-1

AChE-IN-8

AChE-IN-8 is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 1.95 μM. It is primarily utilized in research focused on Alzheimer's disease, where inhibition of AChE can aid in the enhancement of acetylcholine levels in the synaptic cleft. This compound serves as a valuable tool for investigations into therapeutic strategies for cognitive decline associated with neurodegenerative disorders.

Cat. No.

A78713

CAS No.

120013-39-0

ACHE-IN-38 hydrochloride

ACHE-IN-38 hydrochloride is a potent acetylcholinesterase (AChE) inhibitor that effectively reduces the breakdown of the neurotransmitter acetylcholine. By enhancing cholinergic transmission, this compound shows promise in alleviating memory deficits associated with Alzheimer's Disease. It serves as a valuable tool for research into neurodegenerative disorders and the pharmacological modulation of cognitive functions.

Cat. No.

A78714

CAS No.

1363947-94-7

BuChE-IN-12

BuChE-IN-12 is a selective butyrylcholinesterase (BuChE) inhibitor with an IC50 of 0.52 µM, targeting the catalytic and peripheral anionic sites. This compound has demonstrated potential against oxidative stress, making it valuable for exploring therapeutic approaches in Alzheimer's disease research. BuChE-IN-12 serves as a useful tool for investigating the role of BuChE in neurotransmission and related neurodegenerative conditions.

Cat. No.

A78716

CAS No.

271241-14-6

Dimefluthrin

Dimefluthrin is an insecticide that primarily targets the nervous system of insects. It demonstrates significant contact toxicity against large red imported fire ant workers and facilitates horizontal transfer among individuals, resulting in secondary mortality in recipient ants. Additionally, Dimefluthrin acts as a neurodevelopmental toxicant, inhibiting acetylcholinesterase activity, which disrupts neurotransmitter function. This compound is valuable in research applications related to pest control and the study of neurotoxic effects in insect populations.

Cat. No.

A78717

CAS No.

2671859-87-1

S21-1011

S21-1011 is a selective inhibitor of butyrylcholinesterase (BChE) with IC50 values of 0.059 μM for equine BChE and 0.162 μM for human BChE. This compound demonstrates effective blood-brain barrier permeability and favorable pharmacokinetic properties. Additionally, S21-1011 exhibits anti-inflammatory activity by activating the keap1-Nrf2-ARE signaling pathway, with an EC50 of 23.48 μM for antioxidant response element activation. Its potential to ameliorate cognitive impairments in murine models of Alzheimer’s disease makes it relevant for neurodegenerative research applications.

Cat. No.

A78718

CAS No.

460345-17-9

AChE-IN-17

AChE-IN-17 is a potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 28.98 μM. This compound demonstrates significant neuroprotective effects by preventing hydrogen peroxide-induced cell death in PC12 cells. AChE-IN-17 is valuable for research focused on neurodegenerative diseases, providing insights into therapeutic strategies for conditions characterized by cholinergic dysfunction.

Cat. No.

A78719

CAS No.

2417117-84-9

AChE/Nrf2 modulator 1

AChE/Nrf2 Modulator 1 is an orally active compound that targets both acetylcholinesterase (AChE) and the nuclear factor erythroid 2-related factor 2 (Nrf2). It exhibits significant Nrf2 inductive activity along with potent AChE inhibitory effects, presenting IC50 values of 0.07 μM for eel AChE and 0.38 μM for human AChE. This compound is primarily utilized in research focused on Alzheimer's disease, providing insights into neuroprotective mechanisms and cholinergic system modulation.

Cat. No.

A78721

CAS No.

2758788-95-1

AChE-IN-6

AChE-IN-6 is a potent acetylcholinesterase (AChE) inhibitor, exhibiting significant inhibitory activity against both eel AChE (IC50 = 0.20 μM) and human AChE (IC50 = 37.02 nM). Additionally, AChE-IN-6 demonstrates robust anti-amyloid beta activity, with IC50 values of 1.92 μM for inhibiting self-induced Aβ1-42 aggregation and 1.80 μM for promoting disaggregation of Aβ1-42 fibrils. These properties suggest its utility in Alzheimer's disease research, particularly in exploring therapeutic strategies targeting cholinergic dysfunction and amyloid pathology.

Cat. No.

A78722

CAS No.

425611-45-6

BChE-IN-45

BChE-IN-45 is a competitive cholinesterase inhibitor designed to target butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). It demonstrates an inhibition constant (Ki) of 11.13 μM for dual action, with IC50 values of 13.8 μM for BChE and 35.63 μM for AChE. BChE-IN-45 is a valuable tool for research focused on neurodegenerative conditions, particularly Alzheimer's disease, enabling the exploration of cholinergic system modulation.

Cat. No.

A78723

CAS No.

80443-12-5

AChE/BChE-IN-11

AChE/BChE-IN-11 is a potent dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 70 μM and 71 μM, respectively. This natural product, derived from artichoke leaves, exhibits significant biological activity relevant to neurodegenerative disorders. AChE/BChE-IN-11 can be utilized in studies investigating Alzheimer's disease and other conditions linked to cholinergic dysfunction, facilitating the exploration of therapeutic options targeting cholinesterase enzymes.

Cat. No.

A78724

CAS No.

84212-49-7

AChE/BuChE-IN-1

AChE/BuChE-IN-1 is a selective butyrylcholinesterase (BuChE) inhibitor that exhibits an IC50 of 0.48 μM for BuChE and 7.16 μM for acetylcholinesterase (AChE). This compound demonstrates significant scavenging activity against reactive oxygen species (·OH) with an IC50 of 0.1674 μM and effectively inhibits Aβ1-42 aggregation under various conditions (self-, Cu2+-induced, AChE-induced). With high blood-brain barrier permeability and bioavailability, alongside low cytotoxicity, AChE/BuChE-IN-1 is valuable for research into Alzheimer’s disease pathophysiology and therapeutic strategies.

Cat. No.

A78725

CAS No.

185104-11-4

Acotiamide hydrochloride

Synonyms: Z-338; YM443

Acotiamide hydrochloride is a selective and reversible inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 of 1.79 μM. This compound is known to enhance gastric contractility and promote accelerated gastric emptying. Acotiamide hydrochloride is primarily utilized in research focused on functional dyspepsia related to gastric motility dysfunction and intestinal inflammation.

Cat. No.

A78726

CAS No.

6091-57-2

Eseramine

Eseramine is a weak acetylcholinesterase inhibitor with an IC50 value of 9300 nM. Its primary mechanism involves the modulation of acetylcholinesterase activity, making it relevant for research into conditions such as glaucoma, myasthenia gravis, and organophosphate poisoning-related protection. Eseramine serves as a valuable tool in the exploration of therapeutic strategies targeting acetylcholinesterase regulation in various neurological disorders.

Cat. No.

A78727

CAS No.

2421120-68-3

AChE-IN-92

AChE-IN-92 is a highly selective acetylcholinesterase (AChE) inhibitor with an IC50 of 4.6 nM. By inhibiting AChE activity, it effectively prevents the hydrolysis of acetylcholine, leading to increased synaptic levels of this neurotransmitter. AChE-IN-92 is a valuable tool for research focusing on Alzheimer’s disease and related neurodegenerative disorders.

Cat. No.

A78728

CAS No.

2365416-33-5

AChE-IN-113

AChE-IN-113 is a selective inhibitor of acetylcholinesterase, exhibiting a Ki value of 8.3 μM against electric eel acetylcholinesterase. This compound is utilized in research focused on Alzheimer's disease, allowing for the investigation of cholinergic signaling pathways and the potential therapeutic implications in neurodegeneration. Its specificity for acetylcholinesterase makes it a valuable tool for studying enzyme activity and related disorders.

Cat. No.

A78729

CAS No.

184288-35-5

Picfeltarraenin IV

Picfeltarraenin IV is a triterpenoid compound that acts as an acetylcholinesterase (AChE) inhibitor. This compound exhibits significant potential for modulating cholinergic neurotransmission, making it relevant for studies related to neurological conditions. Additionally, Picfeltarraenin IV demonstrates biological activities that may be beneficial in the treatment of herpes infections, cancer, and inflammatory disorders. Its diverse therapeutic applications make it a valuable reagent for research in pharmacology and medicinal chemistry.

Cat. No.

A78730

CAS No.

2755986-33-3

AChE-IN-69

AChE-IN-69 is a potent acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 of 1.67 µM. This compound is primarily utilized in research related to Alzheimer’s disease, offering insights into the modulation of cholinergic signaling. Its inhibitory activity makes it a valuable tool for studying cholinergic dysfunction and potential therapeutic interventions in neurodegenerative conditions.

Cat. No.

A78731

CAS No.

477-58-7

Chondrocurine

Synonyms: Tubocurine

Chondrocurine, an alkaloid derived from the roots of Cissampelos pareira Linn., functions as an acetylcholinesterase (AChE) inhibitor with an IC50 of 7.46 μM. This compound demonstrates significant activity in modulating cholinergic signaling, making it a valuable tool for studying neuropharmacology and related fields. Its application in research may extend to investigations of neurodegenerative diseases and neuromuscular junction disorders.

Cat. No.

A78732

CAS No.

1432738-00-5

AChE/BChE/MAO-B-IN-5

AChE/BChE/MAO-B-IN-5 is a multitarget inhibitor of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidase B (MAO-B). With IC50 values of 0.24 µM, 6.29 µM, and 0.11 µM for AChE, BChE, and MAO-B, respectively, this compound demonstrates potent inhibition of key enzymes involved in cholinergic neurotransmission and monoamine metabolism. AChE/BChE/MAO-B-IN-5 is particularly relevant for research into neurodegenerative diseases, including Alzheimer's disease, due to its ability to penetrate the blood-brain barrier.