Factor Xa

Cat. No.

A74760

CAS No.

432029-12-4

Darexaban glucuronide

Synonyms: YM-222714

Darexaban glucuronide is an active metabolite of darexaban, functioning as a potent inhibitor of Factor Xa. This compound exhibits significant oral bioactivity and demonstrates antithrombotic effects, making it valuable for research into thromboembolic disorders. Its properties support studies focused on anticoagulant therapies and the mechanistic understanding of coagulation pathways.

Cat. No.

A74764

CAS No.

365462-61-9

AS1468240

AS1468240 is a potent, orally active inhibitor of factor Xa (fXa), demonstrating an IC50 of 8.7 nM against human fXa. This compound effectively prolongs coagulation time in murine models, highlighting its potential as an anticoagulant agent. It serves as a valuable tool for research into coagulation pathways and the development of therapeutic strategies for thromboembolic disorders.

Cat. No.

A74765

CAS No.

209187-02-0

YM-60828 methanesulfonate

YM-60828 methanesulfonate is a selective inhibitor of factor Xa (FXa) that exhibits significant antithrombotic properties. In preclinical studies using a rat arteriovenous shunt model, YM-60828 effectively reduces levels of thrombin-antithrombin III complex (TAT) in a dose-dependent manner without prolonging coagulation time. Its specific action on FXa, rather than thrombin, highlights its potential for therapeutic applications aimed at managing thrombotic disorders while allowing for TAT monitoring as a measure of its antithrombotic effect.

Cat. No.

A74767

CAS No.

1379458-40-8

FXa-IN-2

FXa-IN-2 is a reversible inhibitor of factor Xa (FXa), exhibiting an IC50 value of 45.08 μM. This compound is primarily utilized in the research of thromboembolic diseases, enabling scientists to explore the modulation of coagulation pathways and potential therapeutic interventions. Its effectiveness as an FXa inhibitor makes it valuable for studies focused on anticoagulation mechanisms and treatment strategies.

Cat. No.

A74768

CAS No.

637328-69-9

Tanogitran

Tanogitran is a dual inhibitor that targets Factor Xa and thrombin, exhibiting Ki values of 26 nM and 2.7 nM, respectively. This compound demonstrates significant anticoagulant activity, making it valuable for research in thrombotic diseases and related cardiovascular studies. Researchers can utilize Tanogitran to investigate the mechanisms of coagulation and the potential therapeutic applications in anticoagulation therapy.

Cat. No.

A77964

CAS No.

774531-07-6

Idrabiotaparinux

Idrabiotaparinux is a synthetic anticoagulant that acts as a specific, indirect inhibitor of factor Xa. By linking Idraparinux with biotin, this compound enhances its potential for targeted therapeutic applications. Idrabiotaparinux is primarily utilized in research involving blood coagulation pathways and the development of novel anticoagulant therapies.